Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"LINC"”.
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Structural and biochemical characterization of LINC complexes
… by the linker of nucleoskeleton to cytoskeleton (LINC) complexes. LINC complexes are composed of two proteins. The nuclear half is formed by SUN proteins and the cytoplasmic half by KASH-peptide containing proteins. Each KASH protein interacts with different elements of the cytoskeleton and serve …
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The molecular basis of LINC complex formation
… of the nucleoskeleton and cytoskeleton, or LINC, complexes mechanically connect the nucleus with its surroundings allowing for nuclear anchorage and nuclear movement during development and chromosome movement during meiosis. At the heart of LINC complexes are inner nuclear membrane resident …
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Structural studies on the LINC complex and Fic-1
LINC complexes span the nuclear envelope and connect the nucleoskeleton to the cytoskeleton. In 2012, our lab solved the first LINC complex structure, that of SUN domain of human SUN2 bound with KASH1 or KASH2 peptides. In this project testes-specific human SUN proteins (SUN3, SPAG4, and SUNS) were …
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Reading Instruction and Instructors’ Perceptions of Learners’ Needs in LINC Level 1-3 Classes
… Language Instruction for Newcomers to Canada (LINC) Level 1-3 learners. Statistics Canada reports that 60% of immigrants possess inadequate literacy skills. Newcomers are placed in classes using the Canadian Language Benchmarks but large, mixed-level classes create little opportunity for …
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A Study of the LiNC Project: Collaboration, Teaching, Research, and the Social Construction of Technology
… study the Learning in Networked Communities (LiNC) project. The focus of the study is on the social processes involved in the development and deployment of technologies associated with the LiNC project. These processes involved the work of university investigators, software developers, …
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Strengthening Language Instruction for Newcomers to Canada: Learning from Experiences in Saskatoon
… Language Instruction to Newcomers to Canada (LINC) has also been in demand. The purpose of this study was to establish ways in which LINC service providers in Saskatoon can support new ESL LINC instructors to excel in their careers. This study examined the experiences of these instructors in …
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A Nuclear Mechanoresponse to Morphogenesis Drives Acquisition of Neuroectoderm Lineage Competence During Pluripotent Cell Differentiation
… the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex can transduce morphogenesis-associated, actomyosin-generated cellular forces to the nucleus and influence cell state. Nuclear mechanosensitivity can result in changes a cell’s molecular-epigenetic state and regulate gene expression …
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Multi-Conjugate Adaptive Optics for LINC-NIRVANA : Laboratory Tests of a Ground-Layer Adaptive Optics System and Virtical Turbulence Measurements at Mt. Graham
… we calculate performance expectations of the LINC-NIRVANA instrument. In particular, the optimal conjugation heights of the deformable mirrors are studied. Furthermore, we present a new method to measure the atmospheric turbulence near the ground with 40 times increased vertical resolution, …
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Study of the role of plant nuclear envelope and lamina-like components in nuclear and chromatin organisation using 3D imaging
The linker of nucleoskeleton and cytoskeleton (LINC) complex is an evolutionarily well-conserved protein bridge connecting the cytoplasmic and nuclear compartments across the nuclear membrane. While recent data supports its function in nuclear morphology and meiosis, its implication for chromatin …
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Characterisation of the Arabidopsis mid-SUN proteins at the plant NE
… in Linker of Nucleoskeleton and Cytoskeleton (LINC) complex formation at the nuclear envelope (NE), similarly to Cter-SUN domain proteins. In addition to interacting with LINC complex components, they have been reported to localise to both the NE and endoplasmic reticulum (ER). There is also …
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A Linear and Efficient RF Amplifier Architecture for Modern Wireless Applications
… of the signal components, named differential LINC (DLINC), is demonstrated. It is also shown that further improvement in the overall system linearity and efficiency can be achieved by applying the envelope elimination and restoration (EER) technique to the nonlinear gain blocks that amplify …
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Extending the range of linear scheduling in highway construction
… is discussed and a computer software package, LINC, which can be used to generate CMC by input through user-interface screens, is presented. The need for an interface between the Critical Path Method (CPM) and the Linear Scheduling Method (LSM) was identified during the field experience. This …
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(Re)envisioning Land and Power: A Fight for Community Ownership + Control in Massachusetts
… Learning and Innovation for Neighborhood Change (LINC) Lab working sessions with resident researchers, members of the HNSRC and who served as my committee of advising resident researchers, to surface insights into community land issues. Third, I synthesized my academic archival and case study …
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Principled Approaches for Latency Reduction in Networking Systems
… lightning-fast decisions. Second, we present LINC, an in-network coding solution designed for hybrid backbone networks. Through comprehensive mathematical analysis and simulation, we highlight the benefits of network coding in cases where no modifications of the end-hosts are possible. …
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The role of intercultural communicative competence in the acquisition of English as an Additional Language for Arab Learners: A hermeneutic phenomenological study
… Language Instruction for Newcomers to Canada (LINC) program to reveal the challenges that face EAL learners that make it difficult for them using the language effectively in real life situations. In addition, I used journaling as another source of data to review my personal biases and to …
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Mechanotransduction at the nuclear envelope: the role of forces in facilitating embryonic stem cell fate decisions
… Lamin B receptor (LBR) and components of the LINC complex (nesprins/KASH). The structural proteins in the nuclear envelope regulate both the mechanical response of the nucleus to force and the stabilization of peripheral heterochromatin (repressed genes). Our hypothesis is that reducing forces …
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LncRNA discovery in the Listeria monocytogenes infection model
… a handful of studies have identified lncRNAs linc-Cox2, Lethe, PACER and THRIL as central players in host cell innate immune response against microbial infection. These discoveries and the vast numbers of uncharacterized lncRNAs identified by high-throughput nextgeneration transcriptome …
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Critical Moments: Exploring Critical Pedagogy in an Adult ESL Classroom
… Language Instruction for Newcomers to Canada (LINC) program. The teacher-researcher assumed the role of decision-maker and facilitator of the research, with teaching approaches adopting problem-posing. Student participants were actively involved in determining the content and direction of …
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Novel roles of ADF/cofilins in maintenance of homeostasis in normal and malignant epithelial cells
… the linker of nucleoskeleton and cytoskeleton (LINC) complex. Overall, we describe new conceptual insight into the cellular functions of ADF/cofilins. We show that their activities are essential for the dynamic regulation of contractile actin filaments that, if left unchecked, lead to loss of …
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