Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"LIMK"”.
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Mechanisms underlying rapid activity-dependent structural plasticity at Drosophila neuromuscular junctions
… through the effector protein LIM domain kinasel (Limk) to regulate bouton budding. Limk interfaces with structural plasticity by controlling the activity of the actin depolymerizing protein Cofilin. Expression of constitutively active or inactive Cofilin in motor neurons demonstrates that …
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Analysis of Cell-Cell Interactions in the Formation of Drosophila Antennal Lobes
The human orthologs of Neuroglian and Limk have been linked to human nervous system diseases, CRASH syndrome and Williams syndrome, respectively. The characterization of these two conserved genes in the Drosophila brain extends our knowledge of their cellular functions and helps to shed light on …
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P21- ACTIVATED KINASE 4 AND ACTIN CYTOSKELETON DYNAMICS
… MAMMALIAN CELLS. PAK4 PHOSPHORYLATES LIM KINASE (LIMK), WHICH IN TURN, PHOSPHORYLATES THE ACTIN DEPOLYMERISATION FACTOR, COFILIN. COFILIN PHOSPHORYLATION RESULTS IN THE STABILISATION OF THE FILAMENTOUS FORM OF ACTIN. THE PRIMARY GOALS OF THIS PROJECT WERE TO 1) UNDERSTAND HOW THE KINASE DOMAIN OF …
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Effect of oncomodulin on cytoskeletal actin dynamics.
… actin dynamics in OHCs using RhoA/ROCK and LIMK/cofilin mediated pathways. We hypothesize that modulation of calcium signaling through mobile calcium buffers alters intracellular actin dynamics in OHCs. Early studies of OHC lateral stiffness and motility suggest that calcium modifies the …
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Tissue Transglutaminase And Its Role In Human Cancer Progression
… resulted in the identification of a RhoAROCK-LIMK signaling pathway that plays a critical role in directing the biogenesis of MVs in cancer cells.
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Role of Actin and its regulating proteins in drug response
… of the actin regulating proteins, LIM kinases (LIMK1 and LIMK2) in drug resistance. In addition, the role of γ actin, a major actin isoform, in drug resistance was also examined. Chapter 1 reviewed the known mechanisms of antimicrotubule drug resistance and the interaction between the …
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The Role of Rac1 in Synaptic Plasticity, Learning and Memory
… Rac1 mutant significant reduction in p-PAK-1, p-LIMK-1 and p-Cofilin-1, all proteins downstream of Rac1 and essential for cytoskeletal rearrangements leading to dendritic spine development. In order to evaluate the involvement of Rac1 in long term synaptic plasticity (LTP and LTD), hippocampal …