Global ETD Search
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Showing 1 to 15 of 15 for “"LIM-domain"”.
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Regulation of the Intracellular Trafficking of Ajuba by Cell Density and Cell Cycle-Dependent Mechanisms
<p>The intracellular localization of Ajuba, a LIM domain-containing protein, holds essential value for various cellular activities. Previous studies from the laboratory have implicated Ajuba as a repressor of ATR in human cells. This study focused on unveiling the intricate mechanisms governing …
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Studies on the Cytoplasmic Inclusions Detected in Parkinson's disease
… screen. We identified a new interacting protein LIM domain only 7 protein, LMO7. This protein localized in the nucleus, cytoplasm and cell surface, particularly adhesion junctions and contains a PDZ and LIM domain, both of which mediate protein-protein interactions. In this study, LMO7 interacts …
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Molecular and Cellular Mechanisms of LIM Protein Mechanotransduction
… cytoskeletal mechanotransduction is achieved is limited. LIM domain proteins are a superfamily of cytoskeleton-associated proteins involved in cytoskeletal remodeling and transcriptional regulation, but how mechanical forces modulate their functions is unclear. Here, I employed an …
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Die Expression von Androgen-, Vitamin-D-Rezeptor, FHL-2 sowie des Bone Sialo Proteins in primären Mammakarzinomen
… Der Androgenrezeptor-Koaktivator Four-and-a-half-LIM-domain-protein-2 (FHL-2) wurde erst kürzlich als gewebespezifischer Kofaktor des AR beschrieben, bisher jedoch noch nicht in Mammakarzinomgewebe untersucht. <br> <br>Im Rahmen der vorliegenden Arbeit wurde untersucht, ob zwischen dem Nachweis …
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Einfluss von vascular endothelial growth factor, transforming growth factor-beta-1, Interleukin-6, atrial natriuretic beptide, brain natriuretic peptide und Cortisol auf die Gen-Expression des menschlichen Herzmuskels in vitro
… Zytokine ihre Signale vermitteln, und Skeletal-LIM- domain-protein-1 (SLIM-1), ein im Myokard vor kurzem beschriebenes Zinkfingerprotein. <br>Alle Untersuchungen wurden an aus menschlichem Myokard gewonnenen, isolierten Muskelstreifenpräparaten gemacht, die in Organbädern mit den entsprechenden …
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Role of the LPA2 Receptor in Protecting Against Apoptosis
… it to form macromolecular complexes with PDZ and LIM domain proteins, which link it to G protein-independent signaling networks. Using deletion and site-specific mutagenesis, we mapped out C311xxC314 motif of LPA<sub>2</sub>-CT that is required for interaction with LIM domain proteins thyroid …
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Mechanisms underlying rapid activity-dependent structural plasticity at Drosophila neuromuscular junctions
… Wit signals through the effector protein LIM domain kinasel (Limk) to regulate bouton budding. Limk interfaces with structural plasticity by controlling the activity of the actin depolymerizing protein Cofilin. Expression of constitutively active or inactive Cofilin in motor neurons …
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Cloning and characterization of exc-9, a Caenorhabditis elegans CRIP homologue that regulates tubular structure
… EXC-9 is a homologue of the mammalian intestinal LIM-domain protein CRIP. exc-9 is highly expressed in the canal and tailspike, it is also expressed in some other cells, including UTSE, DTCs, and ALM neurons. Promoter regions important for exc-9 expression were studied. It was found that EXC-9 …
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Negative Regulation of the Hippo Pathway by the Ajuba LIM Proteins
… work from our lab has identified the Ajuba LIM proteins as novel negative regulators of the Hippo pathway in both Drosophila and mammals. However, the mechanism by which the Ajuba LIM proteins prevent Hippo pathway activity is not known. Using contact inhibition of proliferation as a …
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FHL2 Inhibits Calcineurin and Represses Pathological Cardiac Hypertrophy
… failure. FHL2 is a member of the four-and-a-half LIM domain (FHL) family of proteins expressed predominantly in the heart. Targeted disruption of FHL2 leads to an exaggerated response to beta-agonist (isoproterenol)-induced cardiac hypertrophy. Isoproterenol-induced hypertrophy relies on …
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Identifying Common Therapeutic Targets in Merlin-deficient Brain Tumours
… at Serine (S) 727 and Tyrosine (Y) 701, PDZ and LIM domain protein 2 (PDLIM2), Heat Shock 70kDa Protein 1A (HSPA1A) and Filamin B (FLNB) as potential common, novel therapeutic targets. We validated these candidates in human primary meningioma and schwannoma tumour cells using a variety of …
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Co-factors of LIM-HD transcription factors in neural development and axon pathfinding in zebrafish
… block motor axon pathfinding by interfering with LIM domain transcription factor signaling. LIM homeodomain proteins (LIM-HDs) are an important class of transcriptional regulators and involved in neural development as well as neuron fate decision in vertebrates. DD domain dimerization of CLIM …
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Identification of the metabolites responsible for colour stability from different lamb sires and elucidation of the underlying biochemical pathways : A thesis submitted in partial fulfilment of the requirements for the Degree of Doctor of Philosophy in Biochemistry at Lincoln University
… Protein 10, superoxide dismutase, thioredoxin domaincontaining protein, tubulin beta chain, annexin 1, Beta 1- metal binding globulin, Tripartite motif family protein, galectin, Apolipoprotein A1, LIM domain binding 3 and myoglobin in differential relative abundance between the colour stable …
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Untersuchung des kardialen LIM-Domänen Proteins FHL2 im menschlichen Myokard : Rolle von FHL2 bei der Herzinsuffizienz
… nach Kofaktoren des Androgenrezeptors wurde ein LIM-only Protein identifiziert, daß als FHL2/Slim3/DRAL mit unbekannter Funktion beschrieben war (Müller et al., 2000). Da Androgene zu Myokardhypertrophie führen können (Marsh et al., 1998), bestand die Aufgabe darin, die pathophysiologische …