Global ETD Search
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Showing 1 to 5 of 5 for “"LIM proteins"”.
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Nukleäre Funktionen des Muscle LIM Proteins in der Herzmuskelhypertrophie
Bei verschiedenen pathologischen Zuständen des Herzens wurde bereits eine vermehrt nukleäre Lokalisation des bislang vornehmlich als Zytoskelett-Protein bekannten MLP beobachtet. In der vorliegenden Arbeit wurde die Lokalisation sowie die Expression von MLP nach Koronarligatur als einem Modell für …
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Role of the Ajuba LIM Proteins in Epithelial Growth Regulation
The mammalian Ajuba LIM proteins: Ajuba, LIMD1, WTIP) are cytosolic adapter proteins recruited to nascent epithelial adherens junctions, where they are thought to contribute to junctional assembly and/or stability. They also shuttle into the nucleus acting as corepressors of the Snail family of …
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Negative Regulation of the Hippo Pathway by the Ajuba LIM Proteins
… work from our lab has identified the Ajuba LIM proteins as novel negative regulators of the Hippo pathway in both Drosophila and mammals. However, the mechanism by which the Ajuba LIM proteins prevent Hippo pathway activity is not known. Using contact inhibition of proliferation as a …
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Molecular and Cellular Mechanisms of LIM Protein Mechanotransduction
… of mechanosensation, the mechanisms by which proteins convert mechanical stimuli into biochemical signals (mechanotransduction) are poorly understood. The actin cytoskeleton serves as a nexus for cellular mechanotransduction, generating and transducing forces into intracellular signals that …
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Role of the LPA2 Receptor in Protecting Against Apoptosis
… it to form macromolecular complexes with PDZ and LIM domain proteins, which link it to G protein-independent signaling networks. Using deletion and site-specific mutagenesis, we mapped out C311xxC314 motif of LPA<sub>2</sub>-CT that is required for interaction with LIM domain proteins thyroid …