Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"LILRB4"”.
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Fc Gamma Receptors Facilitate Antigenic Modulation of LILRB4 and Function as Predictive Biomarkers in Acute Monocytic Leukemia
… <p>Leukocyte immunoglobulin-like receptor B4 (LILRB4) is an immune checkpoint expressed specifically on the cell surface of monocytic AML with limited expression on other cell types, making it an excellent target for antibody-based precision therapy. We have developed an antibody targeting this …
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Structural and molecular studies of group II leukocyte immunoglobulin-like receptors.
… interest has arisen in the Group II receptor, LILRB4, and its role in the induction of immune tolerance via its actions upon dendritic cells and T cells. I attempted ligand-identification and structural studies on LILRB4. Staining of human PBMCs with multimeric LILRB4 revealed broad expression …
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Therapeutic Strategies to Target LILRB Receptors on Myeloid Cells for Cancer Immunotherapy
… major obstacles in cancer treatment. LILRB3 and LILRB4, immune inhibitory receptors containing tyrosine-based inhibitory motifs (ITIMs), are expressed solely on myeloid cells. However, it is unknown whether LILRB3 is a critical checkpoint receptor to support the activity of immunosuppressive …