Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"LIFR"”.
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The Role of LIFR Signaling in Innate Immunity
… pathogen eradication.</p> <p>Here, we uncovered LIFR (leukemia inhibitory factor receptor) restrains low-grade chronic inflammation in the BM by restraining STAT1 signals. LIFR deletion in CD11c-expressing cells resulted in reduced frequency of BM long-term (LT) HSC, increased the frequency of …
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Relevanz der Transmembran- und Intrazellulärregion von gp130, LIFR und OSMR für deren Liganden-induzierte Signaltransduktion
… in order to transmit signals into cells: gp130, LIFR and OSMR. Here it could be demonstrated that the signal transducing capacities of LIFR and gp130 are highly redundant. The box1/2 region of the LIFR recruits the Janus kinases Jak1, Jak2 and Tyk2; the membrane distal tyrosine residues are …
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Analyse der Wechselwirkungen von Proteinen des Interleukin-6-Signalwegs in einzelnen Zellen
… the analysis of gp130 homodimerization and gp130/LIFR heterodimerization in single cells. Interleukin-6 (IL-6) signals through gp130 homodimers while leukemia inhibitory factor (LIF) exerts its action through a heterodimer of gp130 and the LIF receptor (LIFR). Related hematopoietic receptors such …
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Herstellung und Charakterisierung hochaffiner Inhibitoren für die Zytokine IL-6 und LIF basierend auf den Liganden-bindenden Domänen ihrer Rezeptor-Untereinheiten
… that the first five domains of the murine LIFR [LIFR(D1-D5)] were sufficient for a potent binding of human LIF. For inhibition of human LIF the murine LIFR was used since it is known that the murine LIFR binds human LIF with an extraordinarily high affinity. For the precipitation of murine …
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Neuronale und gliale Reaktionen nach Fimbria -Fornix-Durchtrennung : zur Rolle von CNTF und LIF
… Cytokin-Rezeptorenuntereinheiten (CNTFR alpha, LIFR beta, gp130) sowie die Aktivierung des STAT3-Signalweges. Darüber hinaus wurde der Frage nach dem Einfluss der Faktoren auf die postläsionale reaktive Astrogliose im Septumkomplex nachgegangen. Die Ergebnisse lassen sich wie folgt …
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Genetische Untersuchungen zur Rolle von Cytochrom C und Stat3 bei der Regulation des embryonalen Zelltods von Motoneuronen der Maus
… binden an Rezeptorkomplexe, die gp130 und LIFR als signaltransduzierende Komponenten enthalten. Im Gegensatz zu den Rezeptoren für andere neurotrophe Faktoren, führt die Aktivierung von gp130 und LIFR zur Phosphorylierung und Aktivierung des Transkriptionsfaktors Stat3. Es war aber zu …
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Modulation of bovine preimplantation embryonic development and pregnancy by FGF2, LIF, and IGF1
… 5) characterize the necessity for FGFR2, LIFR, and IGF1R for FLI modulation of the developing embryo. Overall, this work illustrated the benefit of FLI supplementation through improved embryo development, cell membrane integrity, and cell survival after cryopreservation. Furthermore, it …
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Effects of work spillover on marital satisfaction
… negative spillover in most areas of domestic lifr throughout thè year, but by the end of the year it was only in the household role and in demands on time that a majority of male teachers experienced negative spillover. Perception of high work spilover among both female teachers' and male …
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Rose Piper: New Discoveries
… career spanned the majority of her working lifr. During the early 1950s she began Ransier Studio Cards, a greeting card company at which she was involved in the entire production process. After the business folded, Piper began a twenty-eight year term in the textile industry where she rose …
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Profiling the inherent vulnerability of motor neuron subtypes
… MN dar. Des Weiteren wurden die Gene Cart, Lxn, Lifr, Ubxn4, Calb2 und Pvalb, von welchen gezeigt werden konnte, dass sie selektiv nur in resistenten MN exprimiert werden, schon zuvor mit neuroprotektiven Funktionen in Verbindung gebracht. Parallel zu der "in silico" Analyse wurden alle 200 …
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Bedeutung von Interleukin-6, Oncostatin M und Interleukin-31 für die biochemische und immunologische Barrierefunktion der Haut
… to abrogate STAT1 phosphorylation. Unlike gp130, LIFR or OSMR the IL-31R is unable to initiate ERK1/2 phosphorylation due to the lack of recruitment of the tyrosine phosphatase SHP2 or the adaptor protein Shc. The strong expression of IL-31 in many skin biopsies from patients with atopic …