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Showing 1 to 20 of 29 for “"LHRH"”.
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The LHRH pulse generator in the New Zealand white rabbit
… I have studied the in vivo activity of the LHRH pulse generator in the rabbit, a reflex ovulator, using a push-pull cannulae (PPC) procedure that allows the detection of the release of this neuropeptide from the hypothalamus of freely behaving animals. The present thesis examines the normal …
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Hypothalamic alpha adrenergic receptors and the regulation of LHRH release
… of luteinizing hormone releasing hormone (LHRH) has been actively investigated since the classic 1947 work of Sawyer. The literature indicates that LHRH release is primarily under the control of the $\alpha$ adrenergic system. The $\alpha$ adrenergic receptor subtype mediating LHRH release …
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The action of ovarian steroids on the hypothalamic LHRH pulse generator
… action of ovarian steroids upon the hypothalamic LHRH pulse generator in the female rat, I have examined the in vivo activity of the hypothalamic LHRH pulse generator in the different endocrine conditions which was followed by the study on the action of progestins on LHRH release from …
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Progesterone Action on Hypothalamic Lhrh Neurons: In Vitro and In Vivo Studies
… luteinizing hormone-releasing hormone (LHRH) neurons, as estimated by in vitro (superfusion) and in vivo (push-pull perfusion) techniques. The administration of P unequivocally stimulated the release of LHRH from hypothalamic tissue obtained from ovariectomized, estradiol-primed (OVX + …
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Localization of Luteinizing Hormone-Releasing Hormone (LHRH) in the Hypothalamus of Fetal Bovine
… localize Luteinizing Hormone Releasing Hormone (LHRH), also known as mammalian GnRH, in the fetal bovine hypothalamus. This analog is believed to differentiate the pituitary primordia during embryonic development and initiate the release ofLH throughout the life of the animal. Localization of …
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Canales iónicos de neuronas septales aisladas: Caracterización electrofisiológica y modulación por TRH y LHRH
… Este trabajo se centra en los péptidos, TRH y LHRH, que se encuentran en alta concentración en el septum, pero cuyo papel fisiológico y mecanismos de acción se desconocen. CONCLUSIONES 1. En este trabajo se ha puesto a punto una preparación de neuronas del SNC de mamíferos adecuada para la …
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Characterization of Luteinizing Hormone - Releasing Hormone (Lhrh) Release From Rat Hypothalamus Using an in Vitro System
… luteinizing hormone-releasing hormone (LHRH) from rat hypothalamus was examined using an in vitro superfusion system and sensitive assays for LHRH measurement. High extracellular (60 mM) K('+) ion repeatedly stimulated in vitro LHRH release, an effect attributed to nerve membrane …
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A Study of the in Vivo Release of Luteinizing Hormone-Releasing Hormone as Estimated With the Push-Pull Perfusion Technique
… of luteinizing hormone-releasing hormone (LHRH) from the mediobasal hypothalami (MBH) of unanesthetized rats and sheep was estimated by means of a push-pull perfusion (PPP) system. Ovariectomized (OVx) rats received 5 (mu)g estradiol benzoate at 1000 h, followed 48 h later by 1.5mg …
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The Role of GABA in Reproductive Neuroendocrine Systems
… the luteinizing hormone releasing hormone (LHRH) pulse generating system.</p> <p>Two animal models (intact and ovariectomized rats) were used to determine the nature of modulation of LHRH release by GABA. The experiment determined the release of LHRH, serotonin (5-HT), and 5-hydroxyindole …
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Generation and characterisation of plant produced recombinant antibodies specific to LHRH for treatment of sex hormone dependent diseases
Leutinising hormone releasing hormone (LHRH) is a hypothalamic neurohormone that plays a pivotal role in the endocrine control of reproduction. Acting through its high affinity receptors on pituitary gonadotrophs, it regulates the secretion of gonadotropins. Manipulation of the neuroendocrine …
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Gonadal steroid regulation of luteinizing hormone-releasing hormone and luteinizing hormone release in the male sheep
… gland to rapidly reduce responsiveness to LHRH, not by rapidly reducing LHRH release, and (4) tyrosine hydroxylase-containing neurons of A14 and A15 are activated concomitant with T-induced suppression of LH release. The conclusion from the final study is (5) neuroendocrine mechanisms …
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Regulation of Luteinizing Hormone and Catecholamine Release
… to determine plasma LH and median eminence LHRH, and hypothalamic catecholamine concentrations were measured by radioenzymatic assay.</p> <p>The first two studies tested whether epinephrine (EPI) synthesis inhibition blocks the accumulation of median eminence LHRH that precedes the ovarian …
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Factors affecting luteinizing hormone releasing hormone and somatostatin release from rat hypothalami in virto
… of luteinizing hormone releasing hormone (LHRH) and immunoreactive somatostatin (IRS), investigated. The viability of the tissue was assessed by oxygen consumption and by the rate of protein synthesis. Protein synthesis continued for up to 60 min but declined rapidly during the next 60 min …
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Study of the pharmacological modification of neuroendocrine mechanisms controlling ovulation in the rat.
… the preovulatory LH surge, which was restored by LHRH or oestradiol plus progesterone. Administration of oestradiol alone restored ovulation to only 43% of RMI 12,936-treated rats. The negative feedback effect of testosterone on LH release showed similar characteristics. Although RMI 12,936 was …
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The hypothalamic-hypophysial-gonadal axis in the freely behaving male rat
… of luteinizing hormone releasing-hormone (LHRH). A consequence of both its anatomical predicament and its rapid half-life, is that LHRH is largely undetectable in the systemic circulation and necessarily must be monitored within the vicinity of the hypothalamic-hypophysial axis. The essence …
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ΣΥΜΒΟΛΗ ΣΤΟΝ ΚΑΘΟΡΙΣΜΟ ΤΗΣ ΕΛΑΧΙΣΤΗΣ ΔΡΑΣΤΙΚΗΣ ΔΟΣΕΩΣ ΟΙΣΤΡΟΓΟΝΩΝ ΣΤΟΝ CA ΠΡΟΣΤΑΤΟΥ
THE EFFECTIVENESS OF LHRH TEST IN THE DETERMINATION OF THE RIGHT DOSES OF OESTROGEN IN THE MANAGEMENT OF PROSTATIC CARCINOMA WAS STUDIED. FOR THAT PURPOSE 48 PATIENTS WITH PROSTATIC CARCINOMA WERE STUDIED. A DOSE OF 100 MG LHRH WAS GIVENINTRAVENOUSLY AND THE LEVELS OF LH AND FSH IN BLOOD SERUM WERE …
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mRNS expresszióbeli változások vizsgálata in vitro AN-152 és doxorubicin kezelés hatására
… jelöltjének, az AN-152 elnevezésű citotoxikus LHRH analógnak és egy klasszikus kemoterápiás szernek, a doxorubicinnek a hatásának vizsgálta egy uvealis melanoma sejtvonal őssejt marker összetételére.
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Peptide Targeting of Platinum Anti-Cancer Drug and Synthesis of Water Soluble Monofunctional Pt(II) Complexes Useful for Biological Labeling
… conjugates were synthesized having the NGR and LHRH targeting motif. The platinum conjugates bearing the NGR motif revealed selective delivery and destruction of cancer cells that had CD13 receptors compared to untargeted carboplatin drug. The development of targeted chemotherapeutic has opened …
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Mechanisms controlling in vitro progesterone synthesis by the ovine placenta
… (cAMP), luteinizing hormone-releasing hormone (LHRH) or no additional treatment. Progesterone concentration in the medium after incubation were determined by radioimmunoassay. The temporal pattern of in vivo progesterone synthesized during gestation exhibited a biphasic increase with elevations …
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