Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"LGP2"”.
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The Role of HOIL 1 Ubiquitin Ligase Activity in MDA5 Antiviral Signaling
… MDA5 signaling. In addition, we have found that LGP2 is ubiquitinated by HOIL1 during virus infection. Given the central role of LGP2 in MDA5 activation, we propose that HOIL1 regulates MDA5 through ubiquitination of LGP2.
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Molecular Mechanism of MDA5 RNA Sensing in Innate Immunity and Disease Pathogenesis
… recognition by MDA5 and its coregulatory factor, LGP2, is essential for initiating antiviral responses. This study aimed to investigate the structure and function of MDA5 and LGP2. I showed the cooperative nature of ATP hydrolysis in MDA5-dsRNA filaments. I discovered that adjacent MDA5 subunits …
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Key Role of Lys63-Linked Polyubiquitination in Viral Activation of IRF3
… receptors (RLRs), including RIG-I, MDA5 and LGP2, are responsible for sensing intracellular viral RNAs. MAVS, a mitochondria-localized transmembrane protein, transduces signaling from RIG-I and MDA5 to activate downstream transcription factors IRF3 and NF-kB, which contribute to the induction …
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Visualisation of innate immune signalling complexes in cells by cryo-electron tomography
… RIG-I-like receptors (RLRs), RIG-I, MDA5 and LGP2 sense cytosolic viral dsRNA and then promote oligomerisation of the mitochondrial antiviral- signalling protein (MAVS) on the outer mitochondrial membrane. MAVS signalling induces activation of cytosolic kinases, which in turn activates …
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Towards Realization of an Innovative Li-Ion Battery: Materials Optimization and System Up-Scalable Solutions
… of Pulp and Paper Science and Graphic Arts (LGP2) in Grenoble (France). A well-known natural material such as cellulose was exploited for the production of innovative low-cost and easily recyclable electrodes for Li-ion batteries. A simple aqueous filtration process, based on a well-known …