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Showing 1 to 20 of 30 for “"LFA-1."”.
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Funktionelle Charakterisierung der Signaltransduktionskaskade des LFA-1-Integrins
… der β2-Integrinfamilie auf Lymphozyten, LFA-1, stand im Zentrum der im Folgenden beschriebenen Analysen. Es gab bereits Anhaltspunkte dafür, daß LFA-1 neben seiner Adhäsionsfunktion auch in Signaltransduktionsprozesse involviert ist. Allerdings sind die molekularen Mechanismen der …
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Regulation of LFA-1 on T cells by phosphoinositide signalling
Lymphocyte Function-Associated Antigen 1 (LFA-1) is the major integrin in T cells and binds Intercellular Adhesion Molecule 1 and 2 (ICAM-1 and ICAM-2) expressed on endothelial cells and antigen presenting cells. LFA-1 affinity for ICAM is increased following chemokine and T cell receptor (TCR) …
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Functional analysis of ICAM-1 : LFA-1 interaction in cell adhesion
… between the counter receptors ICAM-1 and LFA-1, and aimed secondly at studying the mechanisms regulating ICAM-1:LFA-1 mediated cell adhesion. Functional characterization of the purified sICAM-1 demonstrated that radio-iodinated sICAM-1 could bind to LFA-1 positive cells, albeit with an …
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Charakterisierung der funktionalen Rolle von Cytohesin-1 in der LFA-1-vermittelten T-Zell-Adhäsion
Das Leukocyten-spezifische Integrin LFA-1 spielt eine wichtige Rolle bei der Immunantwort, durch die Vermittlung dynamischer Zell-Zell- bzw. Zell-Matrix-Interaktionen. Die kontrollierte Adhäsion bzw. Deadhäsion von Leukocyten bedarf einer spezifischen Regulation des LFA-1-Integrins und die …
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Ingénierie génétique d'une β2-intégrine LFA-1 bovine résistante à la leucotoxine de Mannheimia haemolytica
… on the pathogen side and the beta2-integrin LFA-1 on the host side. The objective of the thesis was to contribute to the understanding of the LKT/LFA 1 interaction at the molecular level. Using a between-species perspective, we showed that (i) the CD11a subunit of the LFA-1 heterodimer was …
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Opposing Actin Networks Modulate the Mechano-Activation of the Integrin LFA-1 During Immunological Synapse formation
… has suggested that the TCR and the integrin LFA-1 are regulated through the application of force on the receptor - ligand bond. This raises the distinct possibility that the robust F-actin flow provides the mechanical force to activate these receptors, thereby enhancing and maintaining …
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Design, synthesis, and evaluation of release kinetics of novel LFA-1 and TLR-4 inhibitor prodrugs for localized immunomodulation.
… development and biological evaluation of novel LFA-1 inhibitor compounds, which inhibit early T-cell trafficking of the adaptive immune system, and the development and evaluation of release kinetics of novel prodrugs of one of these novel LFA-1 inhibitors with poor leaving group ability under …
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Autogramin-2, a synthetic sterol, inhibits T cell adhesion and effector function
… reduction in cell-to-cell contact. Furthermore, LFA-1/integrin dependent adhesion to ICAM-1 and extracellular matrix components was inhibited within 30min of treatment with 3.75M autogramin-2 in an Aster A independent manner. Autogramin-2 did not significantly inhibit LFA-1/TCR downstream …
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Biochemische Analysen zur Funktion und Regulation von Cytohesin-1 in humanen T-Zellen
… (GEF). Dieser aktiviert das b2-Integrin LFA-1 und induziert dessen Bindung an ICAM-1. Cytohesin-1 enthält eine PH-Domäne, diese ist an der funktionalen Regulation des Proteins beteiligt und vermittelt die Membranrekrutierung über Phosphatidylinositol- (3,4,5)-trisphosphat, dem Produkt der …
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Die Rolle des Interleukin-6 bei der Wallerschen Degeneration
… die Makrophagen-Antigene F4/80, Mac-1, LFA-1 und es wurden Semidünnschnitte angefertigt um die Makrophagen-Phagozytose-Aktivität und die Myelindichte zu beurteilen.
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Signaling and Adhesive Mechanisms in Acute Pancreatitis
… 2 (TLR2), TLR4, lymphocyte function antigen-1 (LFA-1), matrix metalloproteinases (MMPs) and Rho-kinase as well as nuclear factor of activated T-cell (NFAT) signaling in AP. We found that TLR4 but not TLR2 plays a role in AP. LFA-1 adhesive mechanisms play a role in tissue damage and leukocyte …
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Regulation of β2-integrins by signalling pathways and cytoplasmic interacting partners
… that regulate β2-integrins (particularly LFA-1, Lymphocyte Function-associated Antigen 1) in B cells and effector T cells. It was now shown that B cells do not require Protein Kinase C βeta or Protein Kinase D for integrin-mediated cell adhesion but inhibition of Phosphoinositide 3-kinase …
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CD44 und variante Isoformen im murinen System
… ein Molekül von großer Variabilität mit einer Vielfalt von Aufgaben. So augenfällig der Zusammenhang zwischen diesen beiden Tatsachen auch scheint, so wenig bestimmte er in den vergangenen Jahren die Forschung. Wichtige Arbeiten, die Funktionalität von CD44 betreffend, behandelten fast …
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Role of Siglec-7 in ganglioside recognition and modulating NK cell biology
… to<br/> modulate integrin functions on NK cells. LFA-1 mediated adhesion of effectors<br/> to ICAM-1-Fc coated plates and the polarization of perforin granules to ICAM-1-<br/> Fc coated beads were negatively affected by the expression of Siglec-7 in the<br/> NK92 cell line. Biochemical analysis of …
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Roles For B-Raf Kinase In The Specific Regulation of Α4Β1 Integrin In T Cells
… and not other integrins such as α5β1 or LFA-1, or a variety of membrane proteins. We demonstrate a novel role for B-Raf in the selective regulation of α4β1 integrin-mediated adhesion.</p>
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Role of ICAM-1, a cell adhesion molecule, in morphological changes of BV2 microglial cell
… no change in other cell adhesion molecules like LFA-1, MAC-1 and β1 integrin a subunit of fibronectin receptor α5β1 even in LPS treated group. LPS also increase the trace number of ramified cells. Therefore; ICAM-1 might play an important role for the LPS-induced morphological changes.
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Integrin Modulating Factor 1 (IMF-1): A lipid that modulates leukocyte integrins
… binding activity of another leukocyte integrin, LFA-1 (α<sub>L</sub>β<sub>2</sub>, CD11a/CD18). However, IMF-1 does not affect the function of representative β<sub>1</sub> and β<sub>3</sub> integrins. IMF-1 has a molecular weight of 340 ± 16 daltons by size exclusion chromatography and appears to …
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Adhesive and signaling mechanisms in abdominal sepsis
… (CLP). It was found that immunoneutralization of LFA-1 or Mac-1 not only reduced neutrophil infiltration but also protected against sepsis-caused lung damage. We observed that HMG-CoA reductase inhibitor regulates pulmonary accumulation of neutrophils via antagonizing CD40 ligand secretion from …
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Antigenexpression von Entzündungszellen bei Polyposis-nasi-Patienten
… der Lymphozyten mit Schwerpunkt auf T- Zellen (LFA- 1, CD4, CD8) und der antigenpräsentierenden Zellen (HLA- DR, CD14, CD1). Die Ergebnisse zeigten überall mehrschichtiges Flimmerepithel ohne Metaplasien und zahlreiche Gefäße, die subepithelial mehr rund, im Stroma mehr sinusoid waren. Die …
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