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Showing 1 to 3 of 3 for “"LETM1"”.
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Structural And Mechanistic Elucidation Of The EF-hand In LETM1 Ca2+/H+ Antiporter Function
… EF-hand containing transmembrane protein-1 (LETM1) is an essential inner-mitochondrial membrane protein that regulates Ca2+ through exchange for protons (H+). LETM1 is an essential gene where haploinsufficiency is associated with Wolf-Hirschhorn syndrome (WHS), characterized by microcephaly, …
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Mitochondrial Calcium Uptake: LETM1 and MICU1 Are Mitochondrial Proteins That Regulate Mitochondrial Calcium Homeostasis and Cellular Bioenergetics
… EF hand containing Transmembrane Protein 1 (LETM1) acts as a regulator of mitochondrial Ca2+ uptake distinct from the mitochondrial Ca2+ uniporter (MCU) pathway (Jiang et. al., 2009). However, a controversy exists regarding the function of LETM1 (Nowikovsky et. al., 2004). Therefore, I asked …
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Analysis of the role of Mdm38 in respiratory chain biogenesis
… Es ist ein Homolog des humanen Proteins LETM1, das mit der Pathogenese des Wolf-Hirschhorn-Syndroms in Zusammenhang gebracht wird. Mdm38 wird für die Biogenese der Atmungskettenkomplexe benötigt, da es sowohl mit dem mitochondrialen Ribosom, als auch mit Mba1 einem Rezeptorprotein für …