Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"LET-60"”.
-
Rb pathway and chromatin remodeling genes that antagonize let-60 Ras signaling during C. elegans vulval development
The synthetic multivulva (synMuv) class A and class B genes act redundantly to regulate Ras-mediated vulval cell fate specification in the nematode Caenorhabditis elegans. The class B synMuv gene lin-35 encodes a protein similar to the mammalian pRb tumor suppressor protein. The LIN-35 Rb protein …
-
Genetic and molecular analysis of let-60 ras, lin-1 and lin-9 : genes that function in C. elegans vulval induction
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1994.
-
Regulation of the Ras Signaling Network in C. Elegans Development
… pattern of cell fates. EGF triggers the LET-60/Ras-LIN-45/Raf-MEK-2/MEK-MPK-1/ERK canonical MAP kinase cascade to induce 1˚ fate and synthesize of DSL ligands for the lateral Notch signal. In turn, LIN-12/Notch induces neighboring cells to become 2˚. In response to lower dose of EGF …
-
blmp-1 is a Ras-cooperating Tumor Suppressor Gene in Caenorhabditis elegans
… homozygous for activated Ras mutations have 60 - 80% penetrant visible multivulval (Muv) phenotype. Several suppressors and enhancers of this phenotype have been shown to be orthologous to Ras-cooperating proto-oncogenes and tumor-suppressor genes, respectively. Because several epigenetic …