Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"LEF"”.
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The dual role of lef-2 in DNA replication and late gene expression during baculovirus-replication
AcMNPV lef-2 is essential for DNA replication and is involved in expression of late and very late gene promoters. In earlier work, the isolation of a virus mutant (VLD1) deficient only in very late protein synthesis was attributed to a point mutation in lef-2. DNA replication and late protein …
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Effects of Lumbar Extensor Fatigue on Ankle Joint Motion Sense and Prolonged Effect on Postural Sway
… of a loss of balance. Lumbar extensor fatigue (LEF) increases postural sway which has been associated with degradations in balance. Study one focuses on the effects of fatiguing time and fatigue level on the duration of these increases in postural sway. Measures of postural sway were collected …
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Wnt/beta-Catenin-Zielgene in der Mausentwicklung
… Signalwegs ist das Protein beta-Catenin, das an LEF/TCF-Transkriptionsfaktoren bindet und so Zielgene des Wnt/beta-Catenin-Signalwegs aktiviert. Ziel dieser Arbeit war die Identifizierung solcher Zielgene in der Maus. Als experimentelles System dienten dabei Maus ES-Zellen, in denen durch …
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The effect of early versus late enteral feeding on the hypermetabolic response of the paediatric burned patient
… compare EEF, to delayed or late enteral feeding (LEF), and to evaluate whether the practice is beneficial in paediatric burned patients. Criteria: The criteria for the patients were (a) a burn less than 24 hours old and a TBSAB more than or equal to 20%, (b) an age of less than 13 years and (c) …
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Wnt-/beta- Catenin Zielgene der frühen Mausentwicklung
… Interaktion des transkriptionellen Komplexes aus Lef-/ b- Catenin mit einem brachyury- Promoterfragment gezeigt und in Transaktivierungsexperimenten, die Relevanz von Tcf-/Lef- Bindungsstellen innerhalb des Promoters nachgewiesen worden. <br>Zur Identifizierung weiterer Wnt- regulierter Gene, …
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Transcriptional Regulation of the Xenopus MyoD Gene
… can repress the expression of the XmyoD gene. Lef-1 is necessary and sufficient for the expression of XmyoD gene. This provides strong evidence that Lef-1 is the transcription factor of the zygotic Wnt signaling pathway that activates the expression of the XmyoD gene.
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Evaluation of tridactyl theropod tracks in southern Africa: quantitative morphometric analysis across the Triassic–Jurassic boundary
… (i.e., near the contact of the informal lEF and uEF). Across this contact, the considered tridactyl tracks become more abundant, larger and have a less pronounced medial digit projection. These morphological changes are gradational, with tracks from the Clarens Formation being distinct to …
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Untersuchungen zur Identifikation von Interaktionspartnern der Nemo-like-Kinase, Nlk
… Interaktionspartner von Nlk sind β-Catenin, LEF-1, XTCF-3 und TCF-4. Im Rahmen der vorliegenden Arbeit wurde versucht, ein sogenanntes Säuger-2-Hybridsystem zu etablieren, anhand dessen neue Interaktionspartner von Nlk identifiziert werden sollten. Die Verwandtschaft mit Cyclin-abhängigen …
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Interactions between BMP and Canonical Wnt Signaling Regulate Critical Stages of the Osteoblast Lifecycle
… lineage allocation mechanism requiring both Tcf/Lef-dependent and Tcf/Lef-independent mechanisms. We next examined BMP/Wnt interactions during proliferation of osteoprogenitors, by focusing on Smad4, a central mediator of the greater TGF-beta/BMP pathway. Acute, tamoxifen-induced deletion of …
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Regulation of late and very late gene expression in both lytic and persistent baculovirus infections
… chitinase A, late expression factor 2 (lef-2) and vp39 were analysed on very late gene expression in overt infections by various approaches such as gene knock-outs, mutagenesis studies or RNA interference. The late proteins cathepsin and chitinase A are viral enzymes required for …
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Functional Similarity of Prd-Containing Virulence Regulators In Bacillus Anthracis
… AtxA controls expression of the toxin genes; <em>lef, cya, </em>and <em>pag</em>, and is the master virulence regulator and archetype PCVR. AcpA and AcpB are less well studied. AcpA and AcpB independently positively control transcription of the capsule biosynthetic operon <em>capBCADE</em>, and …
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Mechanistic Dissection of Tcf7l1-Dependent Enhancer Decommissioning During Exit from Naïve Pluripotency
… to experimentally isolate effects of Tcf/Lef factors on pluripotency. Naïve cis-regulatory elements were specifically bound by and rapidly decommissioned by Tcf7l1 upon releasing cells from Gsk3 inhibition. These findings suggest that Tcf7l1-mediated enhancer decommissioning serves as a …
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COMPARATIVE CELL BASED FUNCTIONAL ANALYSIS OF KEY WNT/BETA-CATENIN PATHWAY GENES AND GENE MUTATIONS
… transcription of its target genes by binding TCF/LEF transcription factors. Aberrant Wnt/Beta-catenin signaling activity leads to misregulation of proliferation and metabolic pathways and has been linked to a number of diseases.
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O Incidente de Desconsideração da personalidade jurídica no âmbito das Execuções Fiscais. Análise à luz da hipótese de responsabilidade Tributária dos Sóciosgestores da Sociedade
… Fiscal, com base na Lei de Execução Fiscal – LEF (Lei nº 6.830/80), bem como o instituto do IDPJ, previsto no novo Código de Processo Civil, para, conseqüentemente, verificar o cabimento do IDPJ nos casos de redirecionamento da Execução Fiscal.
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TCF4-mediated Transcriptional Regulation of Krüppel-like Factor 4 Gene
… 신호 전달 활동을 중재하고, 결장 표면에서 발현되는 primary TCF/LEF family member이다. KLF4 유전자의 변화활동이 TCF4에 의해서 중재되는지 알아보기 위해, Western blot 실험을 통해 HCT116 세포와 HEK293 세포에서 TCF4 발현을 관찰하였다. TCF4 단백질이 HCT116 세포에서는 발현 되었지만 HEK293 세포에서는 나타나지 않았다. 인간 KLF4 promoter에 존재하는 두 개의 conserved 지역에 TCF4 단백질이 binding 하는지 알아보기 위해, …
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Optical properties and energy transfer between C3i and C2 sites of Eu3+ ions in Y2O3 nanocrystal and bulk systems
… energy transfer process between Eu 3+ (C 3i )[Lef-right arrow]Eu 3+ (C 2 ) ions since the lifetimes obtained for 5 D 0 [arrow right] 7 F 2 level lengthened upon C 3i excitation both at 298K and 77K.
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Repertoire Selection Practices of Class B and C Illinois High School Bands
… third instrument, a Literature Evaluation Form (LEF) was sent to an expert panel of three. An examination of the responses of directors (n = 90) indicated that there were nonsignificant relationships between demographic factors and the diversity of repertoire programmed. The most programmed works …
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Die Interferenz des Tumorsuppressor-Homologen p63 mit dem kanonischen Wnt-Signalweg
… Interaktion von ΔNp63α mit Mitgliedern der TCF/LEF-Transkriptionsfaktoren des kanonischen Wnt-Signalwegs nachgewiesen. Diese Beobachtungen sind vereinbar mit einem Modell, in welchem ΔNp63α als Brückenprotein Transkriptionsrepressoren an die Promotoren Wnt-responsiver Gene rekrutiert. Auf diese …
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Application of the technology neutral framework to sodium cooled fast reactors
… new importance measure, Limit Exceedance Factor (LEF), is introduced that measures the margin in system failure probability. It can be used directly with the TNF where standard importance measures cannot. It also reveals that some systems that appear to be of high risk-importance with standard …
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Characterization of bending fatigue mini-specimens for nuclear materials
… bending fatigue machine VSS-40H was designed and LEF-150 was modified with a specially designed adapter to test the fatigue of the mini-specimen. Consequently, the S-N curve for both HT9 and Incoloy alloy MA956 were defined. The endurance limits were measured to be 94 MPa for HT9 and 132 MPa for …
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