Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"LEDGF"”.
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Contribution of LEDGF/p75 to Prostate Cancer Chemoresistance
… lens epithelium derived growth factor p75 (LEDGF/p75) in HRPC resistance to DTX. Our studies show that LEDGF/p75 overexpression attenuates DTX-induced lysosomal destabilization and cell death in a cellular model of HRPC, implicating this stress protein in DTX resistance <em>in virto. …
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The Potential Role of LEDGF/p75 in Prostate Cancer
… the lens epithelial-derived growth factor p75 (LEDGF/p75). LEDGF/p75 is a survival protein that confers resistance to stress-induced cell death. Autoantibodies targeting LEDGF/p75 were detected in 18.4% (38/206) of prostate cancer sera, as opposed to only 4.5% (9/199) in sera from matched …
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Targeting LEDGF/p75 to Sensitize Chemoresistant Prostate Cancer Cells to Taxanes
… Lens epithelium-derived growth factor p75 (LEDGF/p75) is a stressresponse protein that promotes cellular survival against environmental stressors, including oxidative stress, radiation, and cytotoxic drugs. It is overexpressed in PCa and other cancers and has been associated with features of …
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Biochemical and Functional characterization of the LEDGF/p75-MeCP2 Interaction in Tumor Cells
The lens epithelial derived growth factor p75 (LEDGF/p75) is a novel pro-survival and stress-inducible transcription co-activator that protects mammalian cells from various environmental stresses such as oxidative stress, heat shock, and serum starvation. This emerging cancer-related protein is …
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Characterizing interactions between the cellular HIV-1 integration cofactor, LEDGF/p75 with chromatin and HIV-1 integrase
… lens epithelium-derived growth factor/p75 (LEDGF/p75), as well as cellular LEDGF/p75 and chromatin. All three interactions could present novel drug targets and were the focus of my studies throughout my dissertation research. By understanding these critical interactions between the virus and …
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The Role of Glucocorticoid Signaling in Prostate Cancer Health Disparities
… Lens Epithelium-Derived Growth Factor p75 (LEDGF/p75) and Clusterin (CLU). Results revealed a robust pattern of GR-induced upregulation of LEDGF/p75 and CLU in African-American (AA) PCa cells compared to European-American (EA) PCa cells. We also detected increased GR transcript expression in …
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Exploiting Lentiviral Integrations to Profile Chromatin
… the dependency of the lentiviral integrase on LEDGF (Lens Epithelium-Derived Growth Factor). By fusing LEDGF to a chromatin-binding protein of interest, lentiviral integrations are redirected to the genomic targets of that protein, and can be identified through integration site mapping and …
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rd1 Photoreceptor Degeneration: Photoreceptor Rescue and Role of Metalloproteases in Retinal Degeneration
… using Lens Epithelium Derived Growth Factor (LEDGF), Glutathione S-Transferase mu (GST-?? and Glutathione S-Transferase alpha (GST-?? in an organ culture paradigm as well as the role of metalloproteases (MMPs) and their tissue inhibitors in photoreceptor degeneration (TIMPs). The rd1 mouse …
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Mechanistic Insights into Direct Interactions that Mediate the Activity of DOT1L Complex in MLL-Rearranged Leukemia
… Specifically, interactions between the PWWP (LEDGF) domain and histone H3 Lysine 36 tri-methylation; between the CXXC(MLLN) domain and unmethylated CpG of DNA; and between ubiquitylated H2B and DOT1L protein are found to stabilize the intrinsic nucleosome binding property of MLL. AF9, …