Global ETD Search
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Showing 1 to 3 of 3 for “"LDLR degradation"”.
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Characterization of PCSK9-mediated LDLR Degradation in Hepatic and Fibroblast Cells
… subtilisin/kexin type 9 (PCSK9) mediates degradation of low-density lipoprotein receptors (LDLR) indicates a critical role in LDL metabolism. PCSK9 is a secreted protein that binds to the epidermal growth factor-like (EGF)-A domain of LDLR and directs the receptor for degradation in …
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Characterization of the Non-Proteolytic Mechanism and Cellular Site of Action of PCSK9-Mediated Degradation of the Low-Density Lipoprotein Receptor
… and that the secreted PCSK9 binds and degrades LDLRs in liver. To determine if PCSK9 catalytic activity was involved in the degradation of the LDLR, a mutant PCSK9 was engineered that is catalytically inactive. Studies with catalytically inactive PCSK9 demonstrated that the protein degraded …
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Microarray Analysis Identifies Novel Cholesterol Regulated Genes, Including Pcsk9 Which Regulates LDL Receptor Function and LDL Cholesterol Levels
… down-regulates low density lipoprotein receptor (LDLR) levels leading to elevated plasma LDL cholesterol. Furthermore, it was determined that Pcsk9 induces the degradation of the LDLR by a non-proteasomal mechanism in a post-ER compartment. One of the up-regulated genes, A disintegrin and …