Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"LDLR"”.
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Characterization of PCSK9-mediated LDLR Degradation in Hepatic and Fibroblast Cells
… of low-density lipoprotein receptors (LDLR) indicates a critical role in LDL metabolism. PCSK9 is a secreted protein that binds to the epidermal growth factor-like (EGF)-A domain of LDLR and directs the receptor for degradation in lysosomes by an unknown mechanism. A gain-of-function …
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Finasteride lowers cholesterol in humans and delays atherosclerosis progression in Ldlr-/- mice
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01
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Techniques for identifying long-range residue correlations in the fifth binding module of LDLR
… (LR5) of the low-density lipoprotein receptor (LDLR) which regulates the cholesterol level in the bloodstream.
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Characterization of the Non-Proteolytic Mechanism and Cellular Site of Action of PCSK9-Mediated Degradation of the Low-Density Lipoprotein Receptor
… and that the secreted PCSK9 binds and degrades LDLRs in liver. To determine if PCSK9 catalytic activity was involved in the degradation of the LDLR, a mutant PCSK9 was engineered that is catalytically inactive. Studies with catalytically inactive PCSK9 demonstrated that the protein degraded …
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The New Role of Proprotein Convertase Subtilisin/Kexin Type 9: A Connection of Proprotein Convertase Subtilisin/Kexin Type 9, Apolipoprotein B, and Autophagy
… mainly achieved by the uptake via LDL receptor (LDLR). Proprotein convertase subtilisin/kexin type 9 (<em>PCSK9</em>) is a newly discovered gene, playing an important role in LDL metabolism. Gain-of-function mutations of <em>PCSK9</em> lead to hypercholesterolemia and loss-of-function mutations …
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The molecular and cellular defect underlying autosomal recessive hypercholesterolemia (ARH) in the first kindred identified in South Africa
… structure and thus function of the LDL receptor (LDLr). Defects in LDLr binding domain of apolipopreteinB-100 (apoB-100) are rarely encountered and are know as Familial defective apoB-100 (FDB). Several critical proteins are active in the LDL uptake pathway and their deficiencies are now being …
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Modulating Amyloid Beta Clearance by Altering Cellular and Whole Brain Apolipoprotein E Metabolism
… apoE receptor low-density lipoprotein receptor (LDLR) and ATP-binding cassette transporter A1 (ABCA1), a protein that regulates apoE lipidation, have previously been shown to modulate brain amyloid beta levels. In the work presented in this dissertation, we found that increasing LDLR levels …
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Role of Type 2 Cannabinoid Receptor (CB2) in Atherosclerosis.
… we fed low density lipoprotein receptor-null (Ldlr-/-) and Ldlr-/- mice genetically deficient in CB2, an atherogenic diet for 8 and 12 weeks. CB2 deficiency did not significantly affect aortic root lesion area after 8 or 12 weeks; however, after 12 weeks, CB2-deficient lesions displayed …
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Β-carotene promotes atherosclerosis resolution and alleviates liver inflammation in a reversible murine model of atherosclerosis: A potential role of regulatory T cells
… of the low-density lipoprotein receptor (LDLR ASO). To facilitate the development of atherosclerotic lesions, we fed these mice a Western diet (0.3% cholesterol, 41% of calories from fat) deficient in vitamin A (WD-VAD) for 16 weeks, after which we harvested the baseline group. The …
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The Role of Apolipoprotein E Concentration and Isoform in Amyloid-beta Metabolism In Vivo
… the low-density lipoprotein receptor: LDLR), a major receptor for apoE in the central nervous system, which led to a significant reduction of brain apoE concentration. After crossing these mice to a mouse model of β-amyloidosis, the resulting mice exhibited a marked reduction in …
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Dual Receptor Uptake of Low-Density Lipoprotein Docosahexaenoic Acid (LDL-DHA) Elicits Differential Sensitivity Across Breast Cancer Subtypes
… showing some of the highest uptake, mediated by LDLR and SR-B1. LDL-DHA has a higher affinity for LDLR compared to SR-B1 with both receptors being able to mediate uptake. Concurrently, we showed that there is a reciprocal relationship between LDLR and SR-B1, where one receptor compensates for …
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THE IMPACT OF CLEC4A4 DEFICIENCY ON CARDIOMETABOLIC DISEASES
… e WT sono stati generati su background aterogeno Ldlr-/- o ApoE-/- e successivamente sottoposti a dieta ipercolesterolemica per indurre la formazione della placca aterosclerotica. Il fenotipo di questi modelli è stato valutato attraverso analisi istologiche, citofluorimetriche e il dosaggio …
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THE ROLE OF HEPATOCYTE ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) AND APOLIPOPROTEIN M (APOM) IN HIGH DENSITY LIPOPROTEIN (HDL) METABOLISM
… increases are mediated by increased hepatic LDLr expression. ABCA1 deletion also resulted in diminished recycling of HDL-C taken up by the liver back into plasma. Hepatocyte ABCA1 deletion unmasks a novel and selective FC trafficking pathway in which increased LDLr expression accelerates …
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ApoE, ApoER2, and the Regulation of Endothelial Cell Function
… of eNOS. Furthermore, we have determined that LDLR-/-;ApoER2-/- mice have markedly worse atherosclerosis than LDLR-/-, and in preliminary studies ApoER2-/- have impaired reendothelialization. The Overall Goal of this project is to determine how ApoE, ApoER2 and their variants influence …
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A Characterisation and Understanding of the Germinal Centre B Cell Response to Atherosclerosis in Mice using Lineage Tracing
… used and crossed with the atherosclerosis-prone LDLr-deficient mouse model. This model inducibly and specifically labels germinal centre B cells and their progeny using tamoxifen allowing for tracking of atherosclerosis-specific B cell clones comprising germinal centre, memory, and plasma cells. …
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Microarray Analysis Identifies Novel Cholesterol Regulated Genes, Including Pcsk9 Which Regulates LDL Receptor Function and LDL Cholesterol Levels
… down-regulates low density lipoprotein receptor (LDLR) levels leading to elevated plasma LDL cholesterol. Furthermore, it was determined that Pcsk9 induces the degradation of the LDLR by a non-proteasomal mechanism in a post-ER compartment. One of the up-regulated genes, A disintegrin and …
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Role of Macrophage Apoptosis in Atherosclerosis.
… fourteen 8-week-old male LDL-receptor null (LDLR-/-) mice were lethally irradiated and reconstituted with either wild type (WT) C57BL6 or Bax-/- bone marrow. Three weeks later, the mice were challenged with a Western diet for 10 weeks. No differences were found in the plasma cholesterol level …
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Role of Sodium Arsenite in Atherogenesis
… the development of atherosclerosis in ApoE-/- /LDLr-/- mice, (2) determining whether As(III)-induced peroxynitrite activates protein kinase C (PKC) isotypes, α and β, in human aortic endothelial cells (HAECs) and (3) determining the effects of activation of PKC isotypes, α and β, on the …
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Role of Sodium Arsenite in Atherogenesis
… the development of atherosclerosis in ApoE-/- /LDLr-/- mice, (2) determining whether As(III)-induced peroxynitrite activates protein kinase C (PKC) isotypes, α and β, in human aortic endothelial cells (HAECs) and (3) determining the effects of activation of PKC isotypes, α and β, on the …
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IMPACT OF ACLY GENE SILENCING ON HEPATIC LIPID METABOLISM
… e aterosclerosi. Metodi: Topi wild type e topi Ldlr−/− sono stati sottoposti a trattamento mediante iniezioni intraperitoneali di siRNA coniugati a GalNAc, rispettivamente un siRNA di controllo negativo (GalNAc-siCtrl) e un siRNA diretto contro ACLY (GalNAc-siACLY). Gli animali sono stati …
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