Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"LDL-r"”.
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ROLE OF ASGR1 IN METABOLIC SYNDROME, OBESITY, AND ATHEROSCLEROSIS
… atherosclerosis, we backcrossed ASGR1-/- with LDL-R-/- and ApoE-/- mice, generating DKO mice lacking ASGR1-/-/LDL-R-/- or ASGR1-/-/ApoE-/-. Female and male, 2-month-old LDL-R-/- and ApoE-/- mice were fed with a high-cholesterol diet (WTD, western-type diet) for 16 weeks. In DKO mice models …
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Avaliação plasmática, histológica e imunohistoquímica de biomarcadores da aterosclerose humana precoce e crônica
… of cardiovascular risk markers and receptors for LDL-r, CD36 and CD68 in fragments and internal thoracic aorta was determined. Results. Lipid profile data between groups said as chronic (> 56 years) and said as precocious (<56 years) were different (p <0.05). The indices in the group <56 years …
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Homocystéine et ferritine: facteurs de risque additionnels des maladies cardiovasculaires chez la femme ménopausée
… (P < 0.01 ), en lipoprotéines de faible densité (LDL) (P < 0.05) et des triglycérides (P < 0.05). Les lipoprotéines de haute densité (HDL) et le poids corporel sont demeurés inchangés. Les deux groupes ont démontré un état nutritionnel adéquat (aux niveaux sanguin et alimentaire) quant à la …
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Exploring a Diabetic Registry for Cardiovascular Risk Factors
… levels, and low density lipoprotein levels (LDL). Descriptive and inferential statistics were conducted using SPSS Windows version 22. Results: For the total cases (N=292) age ranging 35 years to 97 years, 57% female, the analysis revealed only one independent variable, gender, demonstrated a …
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The Impact of Lipid Nanoparticle Chemistry on RNA Delivery and Therapeutic Outcomes
… bind Apolipoprotein E (ApoE), which can drive LDL-R receptor mediated endocytosis in hepatocytes. In contrast, the surface of 3A5-SC14 LNPs was enriched in Albumin but depleted in ApoE, which likely led to Kupffer cell delivery and detargeting of hepatocytes. In an aggressive MYC-driven liver …
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Flaxseed Lignan Metabolites Modulate Hepatocellular Cholesterol Trafficking In HepaRG
… namely, INSIG-1, SREBP-2, HMGCoA-reductase and LDL-receptor by qPCR and confirmed with western blot analysis. In addition, the possible inhibitory effect of ENL and ENL-Gluc on the uptake of the organic anion transporting polypeptide 1B1 and 1B3 substrate, fluorescein methotrexate (FMTX), was …
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ROLE OF HIGH DENSITY LIPOPROTEINS AGAINST PROSTATE CANCER
… analyses revealed that PCa cells overexpress LDL-R and LRP1, suggesting a reliance on extracellular cholesterol uptake rather than de novo synthesis. This is supported by functional data showing that HMG-CoA reductase inhibition did not alter cellular cholesterol levels in PC3 cells, and by …