Global ETD Search
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Showing 1 to 10 of 10 for “"LDL-cholesterol levels"”.
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Microarray Analysis Identifies Novel Cholesterol Regulated Genes, Including Pcsk9 Which Regulates LDL Receptor Function and LDL Cholesterol Levels
<p>Precise regulation of cholesterol levels is necessary for survival of individual cells and the normal functioning of multicellular organisms. Many of the genes important in these processes are regulated at a transcriptional level by the sterol regulatory element binding proteins (SREBPs) and …
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The Molecular Mechanism Of The Gwas Association Of The Slc22a1 Locus With Metabolic Traits
… acylcarnitine and low-density lipoprotein (LDL) cholesterol levels, suggesting previously unknown roles of SLC22A1 in the regulation of acylcarnitine and cholesterol metabolism. In this study, we aimed to investigate the molecular mechanism by which SLC22A1 and its variants alter plasma …
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DISSECTING THE POLYGENIC LANDSCAPE OF HUMAN COMPLEX TRAITS AND DISEASES IN A SOUTHERN ITALIAN COHORT
… signals, including rs730882080 (FH Naples-3) in LDLR, a pathogenic variant first reported in Southern Italy and associated with elevated LDL cholesterol levels and an increased risk of coronary heart disease. These findings demonstrate the value of studying underrepresented populations to …
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Heart-focused Anxiety and Cardiac Treatment Adherence
… whether heart-focused anxiety predicted healthy LDL, HDL and blood pressure levels above and beyond the influence of demographic variables, other known predictors, and general anxiety. None of the CAQ subscales significantly predicted adherence, but effect sizes were large enough to warrant …
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Low Density Lipoprotein Cholesterol Decreases in Fifth-grade Students Following the Teen Taught KidQuest Program
… a severe nutritional crisis. Rising lipid levels and declining physical activity levels are supporting the increase in childhood obesity, therefore programs encouraging a healthier way of life for today’s children are necessary for treatment of obesity and prevention later in life. The …
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The New Role of Proprotein Convertase Subtilisin/Kexin Type 9: A Connection of Proprotein Convertase Subtilisin/Kexin Type 9, Apolipoprotein B, and Autophagy
<p>Plasma low-density lipoprotein (LDL) levels are positively correlated with the incidence of coronary artery disease. In the circulation, the plasma LDL clearance is mainly achieved by the uptake via LDL receptor (LDLR). Proprotein convertase subtilisin/kexin type 9 (<em>PCSK9</em>) is a newly …
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Associations of genetic variants in ABCB1, ABCG2, CYP3A4, CYP3A5, and SLCO1B1 with statin-associated muscle symptom (SAMS) in South African populations
… Dyslipidaemia, particularly elevated plasma LDL-cholesterol levels, is a key modifiable risk factor for cardiovascular disease (CVD). Statins recognized as LDL-c lowering drugs, have traditionally been the cornerstone in dyslipidaemia treatment and are reported to reduce CVD mortality by …
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The effects of using cottonseed oil versus corn oil as part of an overall dietary strategy to increase vitamin E intake in healthy participants
… oil and corn oil on vitamin E intake and lipid levels. There were no significant changes found between the two groups in regards to change in vitamin E intake. There were no significant changes in cholesterol levels. There was however, a significant change in triglyceride level, with the corn …
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Role of dry beans (Phaseolus vulgaris L.) in binding bile salts and modulating lipid digestion: Impact of the bean matrix and high-hydrostatic pressure processing
… for developing CVD include high blood lipid and LDL-cholesterol levels. A large number of heart attacks and strokes could be prevented by controlling these factors through lifestyle modifications and diet interventions. Epidemiological evidence shows that consumption of dry or common beans …
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In-Vivo and In-Vitro Cholesterol Removal by Lactobacilli and Bifidobacteria
… acid and bile tolerance. Possible mechanisms of cholesterol removal were also examined. All strains showed varying levels of tolerance at pH 2.0 for two hours. L. acidophilus ATCC 4962, L. casei ASCC 290, L. casei ASCC 292, B. longum BB536 and B. infantis 17930 were more acid tolerant than the …