Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"LC3-associated phagocytosis"”.
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Polar Body Membrane Breakdown Occurs Independent of Macroautophagy in C. Elegans
… disorders in mammals. To better understand if LC3-associated phagocytosis (LAP) drives cell corpse breakdown in phagolysosomes, we studied the clearance of the <em>C. elegans</em> polar body during embryonic development. ATG16L1 has separable roles in regulating LC3 recruitment during …
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ATG8 Regulation and Function in Non-Canonical Autophagy
… step of this pathway, ATG8 subfamily proteins (LC3s and GABARAPs) are recruited to double membrane autophagosomes where they facilitate substrate capture, membrane biogenesis and maturation. LC3 proteins can also be recruited to single membrane, endolysosomal compartments through a distinct …
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Novel mechanisms of Atg16L1 recruitment in non-canonical autophagy
… is the recruitment, processing and lipidation of LC3 to autophagosomes. Recently it has become increasingly apparent that, through the unconventional use of some autophagy related proteins, LC3 can also become lipidated to distinct non-autophagosomal membranes of the endolysosomal system. This …