Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"LC-MS analysis"”.
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Derivatization-targeted LC-MS analysis of compounds containing amino group
… sageli kõrglahutusega massispektromeetriat (HRMS). Keerulise koostisega proovides tuvastatakse aga liiga palju ühendeid. Selles töös võetakse kasutusele derivatiseerimisele suunatud analüüsi lähenemisviis, mis ühendab derivatiseerimise ja ühiste fragmentide massispektromeetrilise tuvastamise …
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Further Development and Application of an LC/MS Analysis of Plasma Oxysterol
… the liquid chromatography-mass spectrometry (LC-MS) analysis of 6 clinically relevant oxysterols in order to improve the quantitation, chromatographic resolution and assay throughput. We also explore the use oxysterols as biomarkers in diagnosing and delineating clinical phenotypes of multiple …
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Indole diterpenoid secondary metabolites produced by the Epichloë festucae var. lolii – Lolium perenne symbiosis.
The indole diterpenoid intermediates of lolitrems in a crude extract of Lolium perenne (L. perenne) seed infected with Epichloë festucae var. lolii (E. festucae var. lolii) and their biological activity against porina larvae were investigated. Liquid-liquid partitioning of the crude extract, …
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A Comparison of Theoretical and Actual Coumarin Exudation Under Iron Limitation to Understand Root Exudation Mechanics
… is an important component of plants’ immune systems, largely driven by the act of exuding environmentally influential metabolites from roots. Root exudation may be driven by multiple unique mass-transport mechanisms, including active and passive transport types, though the latter is not …
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Alterations in Genomic 5-Hydroxymethylcytosine Level in Hepatocellular Cancer
… have been shown to initiate HCC. 5-hydroxymethylcytosine (5-hmC), recently identified sixth base of the genome, can cause demethylation by its conversion to cytosine through reactions catalyzed by the TET enzymes. Research on the role of this novel modification in the liver and HCC is needed …
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Metabolomic approaches to understanding the auxin and ethylene response in Arabidopsis roots
… by liquid chromatography-mass spectrometry (LC-MS) was used to determine the metabolite responses of Arabidopsis roots to auxin or ethylene. Crosstalk between these hormones regulates many important physiological processes in plants, including the initiation of lateral root formation and the …
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Development of a mucosal vaccine delivery system
Vaccine delivery systems that target the mucosal immune system carry important advantages in terms of accessibility and acceptability. Lipid based nanoparticles with and without the incorporation of bile salts were formulated by novel preparation methods in order to provide suitable immunogen …
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Chlorogenic and Caffeic Acids’ Impact on Formation of Fluorescent and Non-Fluorescent Advanced Glycation End-Products as a Function of Temperature
… (CML) and carboxyethyl-lysine (CEL) with LC-MS. Chlorogenic acid inhibited the formation of AGEs to a greater extent compared to CA at 25 °C due to CGA’s lower pKa causing it to oxidize faster, thus forming highly reactive quinones that successfully competed with dicarbonyl intermediates …
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Developing Budding Yeast as a Cell Factory for Production of the Antioxidant Ergothioneine
… of EGT in S. cerevisiae was confirmed by both HPLC and LC-MS analysis, and quantification of resultant EGT revealed a significantly (P < 0.0001) larger quantity of EGT present extracellularly in culture supernatants and accumulated therein until the time point of 96 h was reached. To complete the …
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Chromatographic and mass spectrometric characterization of a landfill leachate and an industrial wastewater
… and scientists in the design of treatment systems. Several extraction and analytical techniques were utilized for the analysis of components in complex environmental samples focusing on nonvolatile or thermally labile compounds. Of the extraction procedures evaluated, C₁₈ solid phase extraction …
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Characterisation and Screening of secondary metabolites from Commiphora viminea (Burtt Davy, Burseraceae) Engl. for antifungal properties against Candida auris
… acetone, and ethyl acetate), supported by LC–MS analysis for metabolite identification. The aim was to provide scientific validation for the traditional use of this species and its suitability for natural product research. Qualitative phytochemical screening revealed the presence of diverse …
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Development of a Novel TiO2-polymeric Photocatalyst for Water Purification both under UV and Solar illuminations
… synthesized by reaction of gelatin, polyvinyl alcohol and polyvinyl pyrrolidone. TiO2 Degussa P25 powder was embedded into the polymeric matrix. The characterization of the film by OM, SEM, FTIR, revealed the topography of the catalyst films. Optimization of photocatalysts functionality was …
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The Effect of Alhagi maurorum Medik on Mitochondrial Function
… (MMP), oxidative phosphorylation (OXPHOS), calcium homeostasis and mitochondrial morphology in MCF-7 and MCF-10-A (control) cells after treatment with Alhagi maurorum for 24hr and its main bioactive compound hordenine for 6hr, 24hr, and 48hr are observed. Results indicate that cells treated …
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Using Multiple Screening Strategies to Biologically and Chemically Characterize Natural Products
… high priority natural product fractions. Using LC-MS analysis and bioinformatic approaches, Elastic Net (EN) and Functional Signatures of Ontology (FuSiOn),we further prioritized these 1000 natural product fractions based on sensitivity and mechanism of action predictions, and chemical …
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Evaluation of anti-gout potential of selected Malaysian medicinal plants
… using liquid chromatography-mass spectrometry (LC-MS). E. hirta, S. crispa and C. vespertilionis exhibited XO inhibitory activity in vitro with more than 60 % at 100 µg/mL. Findings showed that the optimum extraction conditions of phytochemical compounds and anti-gout activity of these plants …
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Grape Extracts for Type 2 Diabetes Treatment Through Specific Inhibition of α-Glucosidase and Antioxidant Protection
… a commercial oral hypoglycemic agent. From HPLC and LC-MS analysis, three phenolics from the GSE (resveratrol, ellagic acid, and catechin) were identified as active inhibitory compounds. The acute administration of GPE (400 mg/kg bw) to mice reduced postprandial blood glucose level by 35% …
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Effects of hydrothermal liquefaction on algal toxins from harmful algae blooms
The formation of harmful algae blooms (HABs) in natural waters is an intensifying issue throughout the world and poses risks to the environment due in part to the toxins they release. A promising mitigation technique is to physically collect the HABs from the environment and convert them into …
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Characterisation of Guanylin and Uroguanylin in the Digestive System
… accurately the circulating levels of proforms in human samples. Furthermore, liquid chromatography–mass spectrometry (LC-MS) analysis on human and mouse biological samples challenged the current knowledge of the bioactive peptides. The newly developed immunoassays provided opportunities to …
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The discovery of a role of FBXO7/PARK15 in intracellular trafficking
… yet our understanding of the underlying mechanisms causing the disease is poor, making development of novel therapies challenging. Intracellular trafficking pathways, including Kinesin and Dynein motor transport and the secretory pathway, are emerging as dysregulated pathways in PD contributing …
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