Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"LC-ESI-MS"”.
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In Vitro Metabolism Study of Brevetoxins by LC-ESI-MS
… samples were analyzed by liquid chromatography (LC) coupled with electrospray mass spectrometry (LC-MS). For the incubation sample of brevetoxin- 1, two metabolites were found: brevetoxin-1-M1 and brevetoxin- 1-M2. The tandem mass spectrometry study of the [brevetoxin-1- M1+H]+ led to the …
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LC-ESI-MS/MS quantification of hair cortisol, cortisone and DHEA in combined oral contraceptive users
… many COC adverse effects coincide with symptoms of stress-related illnesses, including insulin resistance and hypertension, it is believed that these adverse effects are a result of chronic biological stress from long-term COC use and that COC users are at greater risk of developing …
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Metabolic Studies on 1-Cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridinyl Derivatives by HPLC and LC-ESI/MS
… interact with N-cyclopropyl analogs of MPTP. HPLC with diode array detection and LC-electrosprary ionization mass spectrometry (LC-ESI/MS) based methods have been developed for metabolite detection and characterization. From the UV spectral data and pseudomolecular ion species observed by …
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Detection of human salivary α-Defensins by LC-ESI-MS and evaluation of levels in athletes after physical stress
… of this study was to optimise and validate an LC-ESI-MS method to determine the level of individual human neutrophil alpha defensins (HNP1-4) after physical stress. A method for the analysis of individual (HNP1-4) in a saliva matrix by LC-ESI-MS has been established. An Agilent 1200 series …
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Structural Studies on the Estrogen Receptor Ligand Binding Domain Using Electrospray Ionization Mass Spectrometry
A protocol using LC/ESI-MS and LC/ESI-MS/MS was developed and used successfully to identify the site covalent attachment of the photoaffinity label hexestrol diazirine. The application of tandem MS/MS sequencing permitted the identification of several residues near the C-terminus of the protein.
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Investigation of protein induction in vascular-targeted strategies.
The aims of the study reported in this thesis were to develop and utilise mass spectrometry imaging techniques (MALDI-MSI), in combination with conventional proteomic methodologies, to investigate protein induction in vascular-targeted strategies. Proteins thought to be involved in tumourigenesis …
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Computational methods in palaeoproteomics: making the most of mass spectrometry data
This thesis addresses the computational challenges that hinder progress in zooarchaeology by mass spectrometry (ZooMS) and liquid chromatography electrospray ionisation tandem mass spectrometry (LC-ESI MS/MS) based palaeoproteomics on ceramics, advocating for the development of open-source, …
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Modern mass spectrometric techniques applied to occupational hygiene analysis.
… Liquid Chromatography/Mass Spectrometry (LC/MS) was used with Electrospray Ionisation (ESI) and Atmospheric Pressure Chemical Ionisation (APCI). Nanospray ionisation was used for the direct infusion analysis of isocyanate samples. Matrix assisted Laser Desorption/Ionisation (MALDI) has …
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Investigating the Molecular Composition of Rainwater and Secondary Organic Aerosol using Ultra-High Resolution Mass Spectrometry
UHRMS has enormous potential to provide complete molecular characterisation of organic aerosol. However atmospheric aerosol often has complex, mixed organic and inorganic composition and soft ionisation techniques that have been developed to ionise organic aerosol specifically, are susceptible to …
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Towards understanding the fate of perfluoroalkyl compounds (PFCs) within urban environments: implications for human exposure.
… about human exposure. The purpose of this thesis is to investigate the presence of perfluoroalkyl compounds (PFCs) in UK indoor and outdoor microenvironments and the impact this may have on human exposure. Both PFOS and PFOA were chosen for analysis (via LC-ESI-MS/MS) because of their highly …
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Análise toxicológica e avaliação de atividades farmacológicas de extrato hidroetanólico de cladódios de Harrisia adscendens (Gürke) Britton & Rose
… composição química do extrato foi analisada por LC-ESI-MS. A toxicidade aguda (2000 mg/kg) e subaguda (doses repetidas de 250, 500 e 1000 mg/kg por 28 dias) e genotoxicidade in vivo (testes do cometa e micronúcleo) foram avaliadas. Atividade antinociceptiva foi avaliada por meio do teste de …
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Investigating the sources and magnitude of human exposure to halogenated organic pollutants using advanced methods for environmental analysis.
Analytical methods based on LC-ESI-MS/MS or LC-APPI-MS/MS were developed and/or validated for the separation and determination of BDE-209 and TBBP-A, in addition to HBCD diastereomers, enantiomers and degradation products in a wide range of samples including air, dust, diet, simulated GIT fluid, …
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INTERACTION BETWEEN PROTEINS OF PLANT ORIGIN AND WINE COMPONENTS: MOLECULAR-BASED CHOICE OF PROTEIN FINING AGENTS FOR ORGANOLEPTIC IMPROVEMENT
… et al., 1999). In accordance with the PhD thesis project, we studied the molecular basis of the interactions between selected plant proteins (soybean, pea, lentil and gluten proteins) and polyphenolic and aroma compounds by using spectrometric and mass spectrometry methodologies (LC-ESI MS, …
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The Group IVA Cytosolic Phospholipase A2/C1P Interaction and Its Role in Eicosanoid Synthesis and Inflammation
… is crucial for production of eicosanoid synthesis in inflammation. Inflammation is a critical component of many disease states including anaphylaxis, cancer, cardiovascular disease, rheumatoid arthritis, diabetes and asthma. Eicosanoids are well established mediators of inflammation, and the …
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Examination of produced water from the Al-Hamada oilfield, Libya.
… different organic and inorganic compounds and residues of oilfield chemicals - added to aid oil water separation) and due to the outcome of increasing volume and effect of discharging, its analysis has become a significant issue of environmental concern. For this purpose and also because of …
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Synthese von Iridoidglykosiden in Pflanzen und Gewebekulturen
… Harpagosid, Aucubin und Catalpol wurden mittels LC-ESI-MS identifiziert und ihre Anteile in den verschiedenen Pflanzenorganen durch HPLC-Analyse bestimmt. Zum Vergleich wurden intakte Pflanzen analysiert. Die in vitro Pflanzen zeigten unterschiedliche Verteilungsmuster an Iridoidglykosiden. In …
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