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Showing 1 to 20 of 1343 for “"LC₅₀"”.
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Entwicklung von Screeningverfahren für Arzneistoffe und Metaboliten mittels LC-MS und LC-MS/MS
Zunächst wurde ein LC-MS Screeningverfahren weiterentwickelt basierend auf einer bereits existierenden Screening Methode auf körperfremde Substanzen mit einer ESI-CID Massenspektrenbibliothek. Diese Bibliothek musste neu erstellt werden wegen Umstellung von der Software-Version eines Macintosh …
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Schnelles und zuverlässiges therapeutisches Drug-Monitoring mit HPLC-UV und LC/LC-MS/MS aus komplexen Matrizes
Voraussetzung für das therapeutische Drug-Monitoring ist, dass die analytische Methode schnell qualitativ hochwertige Ergebnisse liefert. Ausgehend von diesen Kriterien wurden Nachweismethoden für Antimykotika und Antibiotika entwickelt und sowohl in klinischer Routine als auch in klinischer …
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Protein LC-MS Using Slip Flow Chromatography
<p>Histones are essential chromosomal proteins with large numbers of variants and post-translational modifications (PTMs). PTM levels of histones are known to correlate with different stages of cancer. Due to the lack of resolution on intact histone separations, conventional methods for histone …
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Studium nových syntetických drog metodou LC/MS/MS
V současné době se na drogovém trhu objevují nové látky, které jsou zneužívány pro svůj psychoaktivní efekt. Slouží jako alternativa klasických drog (heroin, kokain, extáze atd.), neboť nejsou uvedeny na seznamu zakázaných látek a jejich užívání je legální. Problém těchto látek spočívá v …
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Automatic generation of an LC voltage controlled oscillator
A Voltage Controlled Oscillator (VCO) is used to generate a signal with a frequency that is a function of an input voltage amplitude, and is an integral part of circuits such as phase locked loops, frequency synthesizers, down conversion receivers, and clock generators. A typical design flow for a …
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Characterizing Modified Nucleosides in RNA by LC/UV/MS
<p>Posttranscriptional nucleoside modification is an important characteristic in all types of ribonucleic acids (RNA) and increases the functional diversity of RNA, exceeding that of the four canonical bases. In ribosomal RNA (rRNA) and transfer RNA (tRNA) these modifications enhance RNA structure …
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Evaluation of a particle beam interface for LC/MS
The performance of a Hewlett Packard Particle Beam LC/MS interface is evaluated using EPA appendix VIII and IX compounds. The behavior of these priority pollutants in the interface could determine its feasibility as a future EPA certified technique. The evaluation process consists of studies to …
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In Vitro Metabolism Study of Brevetoxins by LC-ESI-MS
<p>Brevetoxins are natural neurotoxins that are produced by "red tide" algae. In this study, brevetoxin-1 and brevetoxin-2 were incubated with rat liver hepatocytes and rat liver microsomes, respectively. After clean-up steps, samples were analyzed by liquid chromatography (LC) coupled with …
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Derivatization-targeted LC-MS analysis of compounds containing amino group
Aminoühendid, eriti aminohapped, omavad suurt bioloogilist tähtsust, nagu ka nende tuvastamine kliinilises diagnostikas ning näiteks taimede metaboolsete radade ja biomarkerite uurimisel. Nendes valdkondades kasutatakse sageli kõrglahutusega massispektromeetriat (HRMS). Keerulise koostisega …
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Innleiðing einnar mæliaðferðar á LC-MS/MS fyrir átján sterahormón
The adrenal glands along with the gonads and the placenta, produce and secrete steroid hormones. Cholesterol is the precursor for all steroid hormones. The human steroidogenesis can be separated into three major pathways, glucocorticoids, mineralocorticoids and finally sex steroids (adrenal …
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Integrated Tunable LC Higher-Order Microwave Filters for Interference Mitigation
Modern and future communication and radar systems require highly reconfigurable RF front-ends to realize the vision of Software-Defined Radio (SDR), where a single digitally-enabled radio is able to cover multiple bands and multiple operating standards. However, in the increasingly hostile RF …
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Computational Analysis of LC-MS/MS Data for Metabolite Identification
Metabolomics aims at the detection and quantitation of metabolites within a biological system. As the most direct representation of phenotypic changes, metabolomics is an important component in system biology research. Recent development on high-resolution, high-accuracy mass spectrometers enables …
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Characterization of Glycans Derived from Biological Samples Using LC-MS/MS
Proteins are intricate compounds that play vital roles in biological activities. One of the most prevalent post-translational modifications (PTMs) is protein glycosylation, which enhances several biological functions, such as protein stability, localization, cellular communication, inflammation, …
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Linear-block-hyperverzweigte Copolymere und hyperverzweigte LC-Polycarbosilane : Synthese und Charakterisierung
Hyperverzweigte Polymere mit definierter Architektur wurden mittels langsamer Monomerzugabe dargestellt. Die theoretischen Grundlagen wurden experimentell überprüft und in ihrer Tendenz bestätigt. Die erhaltenen hyperverzweigte Polycarbosilane wiesen eine definierte Molmasse und geringe …
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LC - ¹³C NMR utilizing dynamic nuclear polarization (DNP) for signal enhancement
The primary difficulty for successful LC - ¹³C NMR (whether ¹H or ¹³C) is overcoming the relatively low sensitivity of NHR as a chromatographic detector. For the ¹H nuclide this is much less of a problem; the sensitivity ;s approximately 6000 times more sensitive than that of ¹³C nuclei. For this …
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Bayesian Alignment Model for Analysis of LC-MS-based Omic Data
Liquid chromatography coupled with mass spectrometry (LC-MS) has been widely used in various omic studies for biomarker discovery. Appropriate LC-MS data preprocessing steps are needed to detect true differences between biological groups. Retention time alignment is one of the most important yet …
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