Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1343 for “"LC"”.
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Entwicklung von Screeningverfahren für Arzneistoffe und Metaboliten mittels LC-MS und LC-MS/MS
Zunächst wurde ein LC-MS Screeningverfahren weiterentwickelt basierend auf einer bereits existierenden Screening Methode auf körperfremde Substanzen mit einer ESI-CID Massenspektrenbibliothek. Diese Bibliothek musste neu erstellt werden wegen Umstellung von der Software-Version eines Macintosh …
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Schnelles und zuverlässiges therapeutisches Drug-Monitoring mit HPLC-UV und LC/LC-MS/MS aus komplexen Matrizes
… einer zuverlässigen Detektion wurden HPLC- und LC-MS-Methoden erarbeitet. Die Bestimmung per Massenspektrometer bietet die Möglichkeit einer noch spezifischeren Detektion im Vergleich zu klassischen Techniken wie UV-VIS- und Fluoreszenz-Detektion. <br>Für Fluconazol wurde eine …
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Protein LC-MS Using Slip Flow Chromatography
… separation of intact monoclonal antibodies by RPLC; 2) characterization of reduced monoclonal antibodies by nano-RPLC-MS; 3) analysis of ubiquitin and ubiquitin linker in a new pathway of ubiquitination; 4) separation of RRM2 monomer and aggregates. Above results demonstrated the effectiveness of …
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Studium nových syntetických drog metodou LC/MS/MS
… vybrán mefedron včetně jeho metabolitů metodou LC-MS/MS. Byl studován standard, negativní moč s přídavkem mefedronu a reálný vzorek moči potkana, kterému byl podán mefedron. Ve vzorku moči byl detekován mefedron a některé jeho metabolity. Získané informace o zkoumaných látkách mohou být následně …
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Automatic generation of an LC voltage controlled oscillator
… architecture selection based on specification, calculation of circuit parameters, simulation, and iterations of circuit parameters based on the simulation result. In such a design flow, changes in specification or process can lead to significant redesign. This report focuses on a C++ based LC VCO …
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Characterizing Modified Nucleosides in RNA by LC/UV/MS
… modified nucleosides in RNA using optimized LC/MS methods of analysis. This method was shown to be sufficient for characterizing changes in the abundance of modified nucleosides as a function of varying cellular conditions and can be used to explore the dynamics of RNA modification. These …
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Evaluation of a particle beam interface for LC/MS
… performance of a Hewlett Packard Particle Beam LC/MS interface is evaluated using EPA appendix VIII and IX compounds. The behavior of these priority pollutants in the interface could determine its feasibility as a future EPA certified technique. The evaluation process consists of studies to …
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In Vitro Metabolism Study of Brevetoxins by LC-ESI-MS
… samples were analyzed by liquid chromatography (LC) coupled with electrospray mass spectrometry (LC-MS). For the incubation sample of brevetoxin- 1, two metabolites were found: brevetoxin-1-M1 and brevetoxin- 1-M2. The tandem mass spectrometry study of the [brevetoxin-1- M1+H]+ led to the …
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Derivatization-targeted LC-MS analysis of compounds containing amino group
Aminoühendid, eriti aminohapped, omavad suurt bioloogilist tähtsust, nagu ka nende tuvastamine kliinilises diagnostikas ning näiteks taimede metaboolsete radade ja biomarkerite uurimisel. Nendes valdkondades kasutatakse sageli kõrglahutusega massispektromeetriat (HRMS). Keerulise koostisega …
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Innleiðing einnar mæliaðferðar á LC-MS/MS fyrir átján sterahormón
… liquid chromatography tandem mass spectrometry (LC- MS/MS). Today LC-MS/MS is considered a gold standard for steroid hormone measurements. LC- MS/MS technique is both quantitative and qualitative and able to quantitate very low concentrations of analytes and determine complex molecule structures. …
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Integrated Tunable LC Higher-Order Microwave Filters for Interference Mitigation
… On the other hand, Q-enhanced tunable LC filtering has the potential to be implemented at Microwave frequencies from 4~20 GHz and beyond. In this dissertation, a number of Q-enhanced parallel synthesis techniques have been proposed and implemented to achieve high-order, frequency …
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Computational Analysis of LC-MS/MS Data for Metabolite Identification
… Liquid chromatography-mass spectrometry (LC-MS) is a commonly used instrument for metabolomic studies due to its high sensitivity and broad coverage of metabolome. However, the identification of metabolites remains a bottle-neck for current metabolomic studies. This thesis focuses on …
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Characterization of Glycans Derived from Biological Samples Using LC-MS/MS
… coupled to tandem mass spectrometry (LC-MS/MS) stands as one of the most potent tools which is available currently for comprehensive structural analysis of biomolecules. Nanoflow-based reverse-phase liquid chromatography (RPLC) is a powerful and sensitive separation method often …
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Linear-block-hyperverzweigte Copolymere und hyperverzweigte LC-Polycarbosilane : Synthese und Charakterisierung
… eingespart werden konnte. Alle dargestellten LC-Polymere bildeten smektisch A Phasen aus. <br>In ersten Versuchen wurden polymere Netzwerke auf der Basis hyperverzweigter Polymere durch die Copolymerisation eines AB2 Monomers und eines Vernetzers vom AA-Typ dargestellt. Die Netzwerke wurde auf …
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LC - ¹³C NMR utilizing dynamic nuclear polarization (DNP) for signal enhancement
The primary difficulty for successful LC - ¹³C NMR (whether ¹H or ¹³C) is overcoming the relatively low sensitivity of NHR as a chromatographic detector. For the ¹H nuclide this is much less of a problem; the sensitivity ;s approximately 6000 times more sensitive than that of ¹³C nuclei. For this …
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Bayesian Alignment Model for Analysis of LC-MS-based Omic Data
… chromatography coupled with mass spectrometry (LC-MS) has been widely used in various omic studies for biomarker discovery. Appropriate LC-MS data preprocessing steps are needed to detect true differences between biological groups. Retention time alignment is one of the most important yet …
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