Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"LATS"”.
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The inhibition of mammary epithelial cell growth by the long isoform of Angiomotin
… Hippo protein kinase, Large Tumor Suppressor (LATS), which phosphorylates the adapter protein Amot130 at serine-175. Importantly, wild-type Amot130 potently inhibits mammary epithelial cell growth, unlike the Amot130 serine-175 to alanine mutant, which cannot be phosphorylated at this residue. …
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Characterization of the two major merlin isoforms and merlin regulation of YAP
… stabilization of the Hippo-pathway kinase Lats, allowing Lats to phosphorylate and inhibit YAP. In this thesis I identify an additional mechanism for merlin regulation of YAP, which occurs independently of the Hippo-pathway-based regulation. I show that mesothelioma cells expressing merlin …
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Regulation of nitrate uptake and calcium signaling in arabidopsis
… (HATS) and low-affinity transporter system (LATS). A unique calcium signature was identified in root epidermal cells and root hair cell-specific responses were captured in response to low NO3-. Two potential transcriptional regulators (TFs) were identified through gene regulatory network …
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Investigating the Role of Hippo/Warts Signaling in Sarcomatoid Renal Cell Carcinoma
… sRCC: deletion of Hippo pathway kinases Lats1/2 in adult kidney epithelia. Lats1/2 mutant tumors respond to immune checkpoint inhibition (ICI), as is seen in some human sRCCs. Bioinformatic analysis reveals an enrichment of serum response factor (Srf) targets amongst genes upregulated …
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Pre-Service Teachers' Attitudes Toward Language Diversity
… by the Language Attitudes of Teachers Scale (LATS). Independent variables include gender, age, race/ethnicity, teacher certification sought, region, psychological insecurity, cognitive sophistication, and helpfulness viewpoint. Research questions are established and methodology is outlined. A …
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Small-Molecule Activation of Yap for Inner-Ear Regeneration – and Beyond
… Hippo signaling. An ATP-competitive inhibitor of Lats kinases, the compound causes Yap-dependent proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids. The compound promotes the initial stages of the proliferative regeneration …
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Role of the Ajuba LIM Proteins in Epithelial Growth Regulation
… LIM proteins/dJub specifically interact with LATS/Wts and WW45/Sav to inhibit phosphorylation of YAP/Yki. This work describes a novel role for the Ajuba LIM proteins as negative regulators of the Hpo signaling pathway.
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Investigating the novel interaction between hERG and the Fc region of IgG and its consequences
… pro-apoptotic large tumour suppressor kinases (LATS) was identified to alleviate IgG’s effects, suggesting a link between its interaction with hERG and cell death. This is the first evidence of a mechanistic role for this hERG-ITIM and provides insights into not only the role of hERG in …
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Structure-function Analysis of the STRIPAK Complex
… family and their known binding partners, the NDR/LATS kinases, using AP-MS. These studies identified many new MOB and kinase interactors, including a family of guanine nucleotide exchange factors and protein phosphatase 6 (PP6).
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Pseudorabies Virus Latency Associated Transcript Gene: Expression, Regulation, and Role in the Establishment of Latency in Swine
… similar physical properties with the in vivo LATs. The 1.0 and 8.0 kb RNAs partially overlap the first and second exon coding sequences of the in vivo 8.4 kb LAT (LLT), respectively. The entire 2.0 kb RNA overlaps the LLT and has the same intron removed as that in LLT. This 2.0 kb RNA starts …
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Commissionnement virtuel en automatisation: application à la conduite virtuelle d'une ligne de traitement de surface automatisée
… de surface caractérisée par des cuves monobac (LATS). Nous n'avons encouru aucun problème de communication entre le système de commande et celui à commander lors de l'approche SIL, puisque ces deux ont été réalisés dans un seul environnement de simulation par le même ordinateur. Par …
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Functional characterization of nitrate transporters in maize.
… Instead, both HATS and, predominantly, the LATS activities of ZmNPF6.6 were repressed by both T104A and T104D mutations. The equivalent of the predicted nitrate-binding residue in AtNPF6.3 (His356) was investigated in ZmNPF6.4 and ZmNPF6.6. In ZmNPF6.4, a tyrosine residue (Tyr370) is present …
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Fertilizante organomineral de microalgas cultivadas em água residuária: potencial agrícola e ciclo de vida
… (BM) cultivadas em lagoas de alta taxa (LATs), tendo água residuária como meio de cultivo, para a produção de um fertilizante organomineral pastilhado (FOP) em substituição a um fertilizante químico. O fertilizante proposto é composto pela combinação de biomassa de microalgas (BM), …
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Development of Bioluminescent Biosensors Monitoring Activity of the Merlin Tumour Suppressor
All solid tumours share the ability to circumvent or overcome contact inhibition of proliferation (CIP), the process by which cell-cell contacts engage signalling to stop proliferation. Merlin, an ERM-like protein, plays a crucial role in CIP and is inactivated in a wide variety of cancers, …
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Genetic Analysis of The Hippo Pathway In Mouse Liver
… exons in each component (<em>Mst1, Mst2, Sav1, Lats1</em> and <em>Lats2</em>). These mice were then crossed with different cre-mouse lines to generate conditional knockout mice. Results indicate a ubiquitous tumor suppression function of these components, predominantly in the liver. A further …