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Showing 1 to 4 of 4 for “"LARP6"”.
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Mechanisms of Human LARP6 Nuclear Export
The La Related Protein 6 (LARP6) regulates the expression of type I collagen synthesis by binding to the encoding mRNA. However, the molecular mechanism of ligand binding and cellular localization is not fully understood. Understanding the mechanisms of LARP6 regulation requires knowledge of where …
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Biochemical Analysis of Evolutionary Divergent Vertebrate Larp6 Proteins
… of RNA metabolism. The ligand specificity of the LARP6 subfamily is still unknown. The only endogenous ligand for LARP6 is found in the 5’ untranslated region of collagen type I mRNA. Animal studies confirmed that the binding of a particular RNA structure by LARP6 was critical for collagen …
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Elucidating the role of LARP6 in cardiovascular remodeling
… La ribonucleoprotein 6, translational regulator (LARP6), which is an mRNA binding protein described for its contributions to fibrotic remodeling. This is achieved through the interaction between LARP6 and the 5' stem loop (5'SL) of collagen I and III mRNA, which increases their half-life and …
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Role of N-Terminal Region in Modulating RNA Binding Activity of the La Module in Vertebrate LARP6
La-related protein 6 (LARP6) belongs to the evolutionarily conserved superfamily of La-related proteins (LARPs). The LARP6 member is less well known, with most previous work focusing on the RNA binding domain La Module. But previous studies have shown that the N-terminal region (NTR) of LARP6 …