Global ETD Search
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Showing 1 to 5 of 5 for “"LANCL2"”.
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Repurposing BT-11 to Treat Alzheimer’s Disease: Exploring the Glutathione-s-transferase LANCL2 as a Target
… orally active lanthionine synthetase C-like 2 (LANCL2) binding compound, shown to reduce inflammation in the gut and improve cognitive function. Additionally, LANCL2 was identified as a glutathione-s-transferase, suggesting a role in removing toxins and reducing oxidative stress. BT-11 was …
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Computational modeling-based discovery of novel classes of anti-inflammatory drugs that target lanthionine synthetase C-like protein 2
Lanthionine synthetase C-like protein 2 (LANCL2) is a member of the LANCL protein family, which is broadly expressed throughout the body. LANCL2 is the molecular target of abscisic acid (ABA), a compound with insulin-sensitizing and immune modulatory actions. LANCL2 is required for membrane binding …
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Investigations into the roles and molecular mechanisms of LanC-like proteins
… have been revealed. The characterization of LanCL2 function in mammalian cells is described in Chapter 2 and a novel function of LanCL2 as a regulator of Akt activity was identified. LanCL2 promotes Akt phosphorylation and cell survival in liver cells and this regulation is through directly …
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Diverse functions of LanC-like proteins in mammalian cells
… showed that the C-glutathionylation catalyzed by LanCL2 involves formation of DL-(methyl)lanthionine linkages. In order to probe the biological function of C-glutathionylation in mammalian cells, affinity purification mass spectrometry-based (AP-MS) proteomic analysis was performed which is …
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Systems Immunology Approaches for Precision Medicine
… in disease through the evaluation of LANCL2 activation in influenza virus infection. In total, the computational and experimental strategies used in this dissertation are critical foundational pieces in the framework of precision medicine initiatives that can assist in the diagnosis, …