Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"LAG-3"”.
-
Role Of Il-27 And Tcr Stimulation In Inhibitory Receptor Expression
… with TCR stimulation to further upregulate Ly6C, LAG-3, CTLA-4, TIGIT and TIM-3. This IL-27-mediated inhibitory expression was STAT1- dependent. The response to TCR stimulation was graded and thus a stronger TCR stimulus resulted in greater inhibitory receptor expression. In vivo, during infection …
-
Ignimbrítið í Hólafjalli og tengdar myndanir - Rakning myndunarsögu gjóskubergs í Fannardal í Norðfirði
… er helst að rekja myndunarsögu berglaganna. Myndununum var skipt upp í þrjú snið: lag 1, lag 2 og lag 3. Lag 2 liggur ofan á lagi 1 en um 4 m hraunlag er að milli laga 2 og 3. Bæði efri og neðri lagmót lags 3 fundust auðveldlega, sem og neðri lagmót lags 1 og efri lagmót lags 2 en …
-
Stjórnnet Mílu
… má ná með grundvallarbreytingu á stjórnnetinu úr lag 2 (e. Layer 2, OSI líkan verður útskýrt í kafla 2) neti í lag 3 net. Upphafleg hönnun Stjórnnets Mílu tók mið af því að vera einungis á lagi 2 í OSI líkaninu. Byggðir voru upp hringir með sýndarstaðarnetum sem bæði aðgreindu mismunandi tækni og …
-
Clinical Relevance of the Immune Contexture and AXL Kinase in Triple-Negative Breast Cancer
… expression of the immune checkpoints PD-1 and LAG-3 were assessed by immunohistochemistry. Furthermore, to understand the biological and clinical relevance of the interaction between TNBC cells and innate immune cells, we investigated several kinases functioning in the EMT process and their …
-
Potential for using climate forecasts in spatio-temporal prediction of dengue fever incidence in Malaysia submitted
… effects, population, population density and lagged dengue incidence rate as well as climate factors such as average rainfall and temperature, number of rainy days, ENSO and lagged values of these climate variables. Findings include evidence of an increasing annual trend in DIR in all states …
-
NOVEL MONO-, BI- AND TRI-SPECIFIC IMMUNOMODULATORY ANTIBODIES FOR CANCER THERAPY AND TOOLS FOR OTHER THERAPEUTIC AND DIAGNOSTIC APPLICATIONS
… especially regimens including the anti-LAG-3 antibody Relatlimab, promoted an important increase of pro-inflammatory cytokines secretion, such as IL-6, IL-1β, TNF-α, IFNγ and granzyme B. Since combinations of novel mAbs showed a better profile, we decided to fuse the binding moieties …
-
Single-cell analyses of tumor-infiltrating immune cells
… of immunomodulatory receptors (GITR, CD44, LAG-3) that are enriched upon anti- PD-1 treatment. We have also detected subpopulations of cells resembling B cells and dendritic cells in mice known to show positive responses to anti-PD-1 immunotherapy. This immunophenotypic data was corroborated …
-
The role of type I regulatory cells in regulating immune responses to influenza infection
… based on expression of the surface molecules LAG-3 and CD49b. Although all four populations were suppressive, however, only CD49b-expressing Tr1 cells exhibited IL-10-dependent suppression of effector T cell division. These results determined that Tr1 populations from the IAV-infected lungs …
-
A new hybrid model of dengue incidence rate using negative binomial generalised additive model and fuzzy C means model a case study in Selangor
… number of rainy days with current month up to lag 3 months are significant to DIR. Besides, the interaction between rainfall and number of rainy days also shows strong positive relationship to DIR. Meanwhile, non-climatic variables such as population density, number of locality and lag DIR from …
-
Hedge Fund Ownership and Auditor-Client Contracting In U.S. Firms
… fund ownership and (1) audit fees, (2) audit lag, (3) issuance of going concern opinions, and (4) auditor resignation.</p> <p>This research is an archival study. The sample consists of publicly listed firms incorporated in the U.S. for the period 2005-2017 containing 30,047 firm-year …
-
Mechanisms Mediating Asthma Tolerance Induced By Regulatory Dendritic Cells Through CD4+CD25+Foxp3+ T Regulatory Cells
… of the Treg-associated markers ICOS, PD-1, GITR, LAG-3 and CTLA-4 on pulmonary Treg cells in treated asthmatic mice while DC10 (CD80-/-CD86-/-), DC10 (Iab-/-) and DC10 (IL-10-/-) treatments lead to reduced Treg activation. This demonstrated that the activities of tolerogenic DCs are differentially …
-
Modeling of Cns Cancer With A Focus On The Immune Component
… for cellular growth as well as to create collagen, which is necessary for wound repair and found in high levels in brain tumors. Our hypothesis is that through manipulation of the Arg1 axis in myeloid cells we will increase anti-tumor response. We show the groundwork for evaluating whether or …