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Mutations in Phospholamban Alter the Structure and Function of the Calcium ATPase Regulatory Complex

Abrol, Neha2016

… PLB that cause heart failure including L39stop (L39X) and Arg9Cys (R9C). Alanine substitution of PLB C-terminal residues significantly altered FRET from PLB to PLB and SERCA to PLB, suggesting a change in quaternary conformation of PLB pentamer and SERCA-PLB regulatory complex. We also quantified …

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