Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"L1CAM"”.
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Efficacy of novel immunotherapeutic strategies targeting L1CAM in pancreatic cancer
… options is the L1 cell adhesion molecule (L1CAM) which is upregulated in PDAC cells in most PDAC tissues and associated with different hallmarks of cancer contributing to therapy resistance, immune evasion and tumor progression. This study analyzed the therapeutic efficacy of two antibody …
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CROSSTALK BETWEEN TUMOUR VASCULATURE AND OVARIAN CANCER STEM CELLS: THE ROLE OF L1CAM.
… limitations of current treatments. We identified L1CAM, an adhesion glycoprotein, expressed both in tumour endothelium and epithelial cancer cells, as a mediator of the interaction between the vascular TME (vTME) and OCSC. L1CAM expression correlates with metastatic spread and poor outcome, …
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Modelling neurodegenerative diseases in human iPSC-derived neurons
… beads. Finally, Chapter 5 establishes L1CAM as a novel autophagy modulator; iPSC-derived neurons showed that reduction of the L1CAM transcript with shRNAs, but not genetic knockout of the L1CAM protein, is sufficient to reduce transcription of the ATG8 gene family, which are core …
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Identify the regulatory roles of intestinal secretory cell lineages during gut inflammation
… and the immune system. This was characterized by L1CAM-mediated activation of type 2 innate lymphoid cells (ILC2s), which promoted secretion of Th2 cytokines IL4, IL6, and IL13, thus enhancing inflammatory responses. This pathway presents a potential target for therapeutic intervention, …
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Efeito do cromossomo x no mapeamento de regiões genômicas sobre características de interesse econômico em búfalos da raça murrah
… PABPC5, G6PD, GDI1, RPL10, FLNA, MECP2, and L1CAM). This study provided greater insight into the strong association of X chromosome markers with reproductive traits in females, and these findings may contribute to understanding economically relevant biological processes in buffalo species.
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Eph-Ephrin Signaling and the Role of EFN-4 in Caenorhabditis Elegans Nervous Systems Development
… to at least one other binding partner the L1CAM (L1 Cell Adhesion Molecule) LAD-2. VAB-1 may have additional functional roles in guiding AIY primary neurite outgrowth to the central plexus. Our findings suggest EFN-4 is a key player in cell-to-cell communications that guide AIY neuronal …
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Stress-induced remodeling of the caenorhabditis elegans dauer
… downstream effector complex comprising of the L1CAM homolog SAX-7 to control branching. Chapter 4 compares regulation of this complex between stress-induced IL2 branching and FLP branching. Here I find a previously unknown genotype by environment interaction within the UPR, demonstrating …