Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 41 for “"L. pneumophila"”.
-
The role of biofilms in Legionella pneumophila transmission in drinking water distribution system
… and transmission of pathogenic Legionella pneumophila (L. pneumophila), thus raise human health concerns. L. pneumophila cells can accumulate in biofilms, be protected from disinfection by biofilms, and then be released from biofilms with detached biofilm materials or by the drinking water …
-
A study of the relationship between viability, culturability and virulence in environmental populations of Legionella pneumophila
… In order to study this phenomenon in Legionella pneumophila, a model hot water system was constructed to serve as a source of planktonic and biofilm cells. Both planktonic and biofilm L. pneumophila existed primarily as nonculturable cells. A portion of these nonculturable cells were shown to be …
-
Secretion and Environmental Biochemistry of Legionella pneumophila in Corrosive Water
Legionella pneumophila and other opportunistic pathogens of drinking water pose important problems at the interface of biology, environmental engineering, public health, and governance. In this thesis, I explore the molecular mechanisms permitting survival of L. pneumophila in built water systems …
-
Nutrient availability modulating physiology and pathogenicity of <i>Legionella pneumophila</i>
A virulent strain of <i>Legionella pneumophila</i> serogroup 1 was established in continuous culture under defined iron-replete conditions at pH 6.9. Iron-limitation and extremes of pH (6.0 and 7.8) influenced the growth and metabolism of <i>L. pneumophila</i>, as manifested by increased metabolic …
-
Proteomic and genomic characterization of the influence of copper on Legionella pneumophila and the drinking water microbiome
Legionella pneumophila is a pathogen that can proliferate in premise (i.e., building) plumbing and, when aerosolized during water use, infect the lungs of exposed individuals and cause a deadly form of pneumonia known as Legionnaires' disease. Given that it is one of the primary sources of …
-
The colonisation of treated water systems by <i>Legionella pneumophila</i>
… developed to investigate the ecology of <i>L. pneumophila</i>. The inoculum was derived from a calorifier responsible for an outbreak of Legionnaires' disease and contained virulent <i>L. pneumophila</i>a serogroup 1 along with associated microorganisms including protozoa. The model system was …
-
Effect of Various Water Chemistry Factors on Legionella Proliferation and the Premise Plumbing Microbiome Composition
… opportunistic pathogens, including Legionella pneumophila which can regrow in premise plumbing and cause disease in immunocompromised populations. The goal of this work was to explore engineering methods for control of L. pneumophila and total regrowth. The first line of study involved a series …
-
Wirtsspezifität der Gattung Legionella und Etablierung von Dictyostelium discoideum als Wirtsmodell
… und L. lytica sowie der humanpathogene Stamm L. pneumophila Corby. Außerdem scheint die Virulenz humanpathogener Legionellen-Spezies korreliert zu sein mit der Nutzung eines breiten Wirtsspektrums. Ciliaten wie Tetrahymena pyriformis sind im Gegensatz zu den Amöben als Wirte nicht so gut …
-
Molekularbiologische Studien zur Pathogenität und Ökologie von Legionella pneumophila
Legionella pneumophila, der Erreger der Legionärskrankheit, ist ein Umweltkeim mit Verbreitung in aquatischen Habitaten. Die Keime sind in der Lage, sich intrazellulär in eukaryontischen Zellen, wie Makrophagen, Monozyten und Protozoen zu vermehren. Die erfolgreiche Besiedlung ökologischer Nischen, …
-
Environmental regulation of the growth, physiology and virulence of <i>Legionella pneumophila</i>
… of legionellosis are caused by <i>Legionella pneumophila</i> serogroup 1. A number of pathogenic bacteria regulate their virulence gene expression in response to environmental stimuli. Temperature and the availability of iron are considered to be stimuli which signal entry to a host …
-
The integration of an avirulent legionella pneumophilla into aquatic biofilms
… phase of the system. An avirulent Legionella pneumophila was inoculated into the system and was subsequently isolated from both biofilms and also from the aqueous(planktonic) phase of the chemostat. The attenuation of this strain, determined by its inability to cause disease and death in …
-
Implementation of molecular techniques in the diagnosis of legionnaires’ disease and in the investigation of legionella outbreaks
… of the Legionella genus, in particular L. pneumophila serogroup (sg) 1 alone causes about 95% of culture confirmed cases. The infection is usually acquired by inhalation of aerosols originating from contaminated fresh water sources, consequently typing of both clinical and environmental …
-
Dictyostelium als Wirtsmodell und Funktionsanalyse des Virulenzfaktors Mip aus Legionella pneumophila
Legionella pneumophila wurde erstmals 1977 beschrieben, nachdem der Erreger aus dem Lungengewebe eines Patienten isoliert wurde, der an einer schweren atypischen Pneumonie erkrankt war. Das Bakterium zeichnet sich durch ein duales Wirtssystem aus und kann sich sowohl in Protozoen als auch in …
-
An assessment of health hazards associated with the use of water mist systems as a cooling intervention in Australia
… plumbing pathogens (OPPPs) such as Legionella pneumophila, Pseudomonas aeruginosa, Mycobacterium avium, Acanthamoeba and Naegleria fowleri is emerging as a challenge for public health and water quality management. Contrary to other premise plumbing features like showers and domestic taps that …
-
Dose Determines if Soluble Copper is a Nutrient or an Antimicrobial for Legionella pneumophila in Premise Plumbing
The effect of copper on Legionella pneumophila in potable water plumbing systems is dependent on its dose and water chemistry. For instance, prior research demonstrated that the presence of aluminum hydroxide from anode rods in water heaters can bind copper and render high doses non-toxic. On this …
-
Disinfection of wastewater for reuse using microchannel plasma ozone generator
… potential public health concerns is Legionella pneumophila. This thesis investigated the performance of an energy efficient and compact microchannel plasma-based ozone generator to inactivate L. pneumophila for safer water reuse. Inactivation kinetics study quantified the inactivation. More than …
-
A Framework for Controlling Opportunistic Pathogens in Premise Plumbing Considerate of Disinfectant Concentration x Time (CT) and Shifts in Microbial Growth Phase
… versus water retention time (T). Legionella pneumophila was not detectable in pipes with a CT > 78 mg*min/L over a 24 hour period, which is comparable to reported CT thresholds for 3-log inactivation of biofilm-associated L. pneumophila in batch experiments. There was a tradeoff between …
-
Identification and characterization of phosphoinositide-binding Legionella effector proteins
… facultative intracellular bacterium, Legionella pneumophila (hereafter Legionella), has adopted a survival strategy that relies on the establishment of a protective vacuole that avoids encounters with the endolysosomal pathway. Legionella is an important cause of hospital- and community-acquired …
-
Effect of Water Chemistry, Pipe Material, Temperature and Flow on the Building Plumbing Microbiome and Opportunistic Pathogen Occurrence
… pathogens (OPs), such as Legionella pneumophila. This dissertation applied next-generation DNA sequencing tools to survey the composition of building plumbing microbiomes and assessed hypothetical factors shaping them. A challenge to identifying key factors shaping building plumbing …
-
Entwicklung eines GFP-Reportersystems in Legionella und molekularbiologische Funktionsanalyse des Legionella Mip-Proteins
… fakultativ intrazelluläre Bakterium Legionella pneumophila wurde erstmals 1977 als Erreger der Legionellose, einer schweren atypisch verlaufenden Pneumonie identifiziert. Es besitzt ein duales Wirtssystem und kann sich sowohl in aquatischen Habitaten in Protozoen als auch in phagozytierenden …
Page 1 of 3