Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"L-tyrosine"”.
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The Crystal Structure Analysis of L-Arginine Dihydriodide and L-Tyrosine Hydriodide
Made available in DSpace on 2014-12-09T17:35:41Z (GMT). No. of bitstreams: 1 6706727.pdf: 5650685 bytes, checksum: 95da4d30abdc8bb3fabfc474690065ba (MD5) Previous issue date: 1966
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Comparative analysis of Anopheles gambiae L-tyrosine decarboxylase and L-DOPA decarboxylase
… in insects is through the decarboxylation of tyrosine and DOPA, respectively. Although tyrosine decarboxylase (TDC) has been mentioned in some reports, it has never been critically analyzed. The high sequence identity shared by tyrosine decarboxylase and DOPA decarboxylase in insects, and the …
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Peptide Vaccine Formulation Controls The Duration of Antigen Presentation and Magnitude of Tumor‐Specific Cd8+ T Cell Response
… anti‐tumor efficacy. Here we describe L‐tyrosine amino acid‐based microparticles as a novel peptide vaccine adjuvant for the induction of tumor‐specific T cells. L‐tyrosine microparticles did not induce inflammasome activation, but instead extended antigen presentation time. The …
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Combinatorial search strategies for the metabolic engineering of microorganisms
… using the metabolic engineering framework of L-tyrosine overproduction in Escherichia coli. Although this particular strain optimization problem merely represents a "model system" for these studies, such endeavors do have important industrial implications, as L-tyrosine serves both as a dietary …
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Direct bromine-80 or bromine-82 labelling of biomolecules via excitation labelling methods: preparation of radiopharmaceuticals
… substrate molecules, such as deoxyuridine, L-tyrosine, guanosine, deoxycytodine, phenylalanine and acetic acid, to gaseous CF₃<sup>82m</sup>Br (or CF₃<sup>80m</sup>Br) was studied. The radiochemical yields of the brominated products are relatively small and range from 1% in the case of …
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The role of melanin production in the survival of Vibrio cholerae in the marine environment
… produces pyomelanin through the catabolism of L-tyrosine to homogentisic acid. Various types of melanins are used by microbes as defense mechanisms against a variety of environmental stresses. This thesis investigated the defensive role of V. cholerae pyomelanin against exogenous stresses, …
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The biosynthesis of brominated tyrosine metabolites by Aplysina fistularis
The biosynthesis of brominated tyrosine metabolites by the marine sponge Aplysina fistularis was investigated. ($U$-$\sp{14}$C) -L-Tyrosine, ($U$-$\sp{14}$C) -L-3-bromotyrosine, and ($U$-$\sp{14}$) -3,5-dibromotyrosine were incorporated into both dibromoverongiaquinol and aeroplysinin-1, and …
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Process-structure-property relationships of resorbable desamino tyrosine derived polymers : effect of backbone chemistry and assembly on drug delivery
… with different properties are very important. L-tyrosine derived polymers enable the manipulation of the properties of the material by changing backbone or pendent chain structure. L-tyrosine derived polyarylate is one of the class of these materials. This study investigates the behavior of the …
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Ocular pharmacokinetics and efficacy of various amino acid and dipeptide prodrugs of ganciclovir
… keratitis rabbit models. In conclusion, L-Tyrosine-L-Valine-GCV among peptide ester prodrugs and L-Valine-GCV among the amino acid ester prodrugs exhibited superior corneal absorption and bioavailability in comparison with GCV. This might be due to the absorption of these drugs via both …
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The development of a simple process for producing medicinal diagnostic 18F agents for molecular imaging using positron-emission-tomography
… new synthetic route to O-(2-[18F]-fluoroethyl)-L-tyrosine.<br/><br/>A fluorinated analogue of Alzheimer’s disease drug (?)-galanthamine was synthesised with complete stereocontrol as a potential new imaging agent for use in PET.
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Optimalisation de la radiosynthèse et production au niveau de la curie d'acides aminés aromatiques marqués au fluor-18
6-[18F]fluoro-L-dopa (FDOPA) and 2-[18F]fluoro-L-tyrosine (FTYR) are useful radiopharmaceuticals for evaluation by positron emission tomography (PET) of the dopaminergic function and oncological studies, respectively. In comparison to electrophilic synthesis, the no-carrier-added (nca) nucleophilic …
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Phenotypic diversity as a tool to guide and optimize random strain improvement approaches
… accumulation of hyaluronic acid, and L-tyrosine production.
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Syntheses of natural bioactive 3-acyltetramic acids and derivatives
… donor atoms in the side chain). Therefore, a L tyrosine derived tetramic acid was coupled to different side chains, which were synthesised separately, by applying varying 3 acylation conditions. Macroetherification via palladium catalysis and subsequent deprotection provided the desired …
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Structures of the Didemnins (Antiviral, Antitumor, Compounds)
… (Leu), L-proline (Pro), and N,O-dimethyl-L-tyrosine (Me(,2)Tyr), and a 2R,4R-hydroxyisovalerylpropionyl (Hip) group. Didemnins B-E differ from didemnin A by acylation of the methylamino group of MeLeu with the substitutents shown. Didemnin B is the most active of these compounds, possessing …
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Effects of dietary tyrosine and tryptophan supplementation on immunity and brain neurotransmitter levels after SRBC injections in chickens
This study investigated the effects of dietary tyrosine or tryptophan supplementation on immunity and brain neurotransmitter levels after antigen challenge. Chickens were given 0.1%, 0.5% or 1% supplemental dietary L-tyrosine or L-tryptophan prior to the injection of sheep red blood cells (SRBC). …
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THE DETERMINATION OF STABILITY CONSTANTS AND COMPLEXING CAPACITIES OF NATURAL ORGANIC MATTER FOR COPPER (2+), COBALT (2+) AND MANGANESE (2+) BY FLUORESCENCE QUENCHING TITRATION
… level. Titrations of the model compound L-tyrosine prove the validity of the technique. Fluorescence data for SFA with Cu('2+) at pH 5, 6 and 7 compares well with results for the same material using different techniques. The binding of Cu('2+) to SFA is much stronger than Co('2+) and …
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Silica Polypeptide-Based Colloids: Physical Properties and Novel Materials
… PCBL and poly(o-benzyl-L-tyrosine), PBTY. Attachment of a well-characterized alkyne-end terminated PSLG and PCBL to an azide- functionalized particle yielded PCPs with a desired sparse coverage. A blend of techniques such as FTIR, XPS, TEM, HTEM, XRD, GPC, MALDI-TOF, DLS, …
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Biochemical Studies of Aromatic Amino Acid Decarboxylases and Acetaldehyde Synthases
… the oxidative stress of H2O2. We then compared tyrosine decarboxylase (TyDC) with DDC. As the enzyme catalyzing the first step of insect neurotransmitter tyramine/octopamine synthesis, the biochemical characteristics of insect TyDC have not been thoroughly elucidated yet because of the …
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The Oxidative Deamination of Sulfur Amino Acids by a Bacterial L-Amino Acid Oxidase
… L-phenylalanine, L-tryptophan, L-arginine, L-tyrosine, L-histidine, L-ornithine, L-citrulline, L-lysine and L-isoleucine with a pH optimum at 7.5. Specific activity, pH optimum, K<sub>m</sub> and V<sub>max</sub> values were determined for each sulfur amino acid. The ordered rate of reaction at …
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Protein containing porous polymers for biocatalytic applications
… transesteriflcation reaction between N-acetyl-L-tyrosine ethyl ester (A TEE) and propan-l-ol by high performance liquid chromatography (HPLC). Immobilised enzyme activities were compared to those obtained for simple unsupported lyophilised preparations of a-chymotrypsin. Uniform porous …
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