Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"L-type calcium channel"”.
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Oxidant-dependent regulation of L-type calcium channel activity by angiotensin in vascular smooth muscle
… which directly increases peripheral resistance. Calcium influx through voltage-gated L-type calcium channels underlies vascular smooth muscle contraction. Roughly half of calcium influx in these cells occurs through a small number of persistently active channels, whose activity increases with …
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Characterization of L-type Calcium Channel Binding-Site of a new class of Calcium modulators by a Multidisciplinary approach
… ileum longitudinal smooth muscle. Wild-type human heart and rabbit lung α1 subunits were expressed (combined with the regulatory α2δ and β3 subunits) in Xenopus Leavis oocytes using a two-electrode voltage clamp technique. Diltiazem is a benzothiazepine Ca2+ channel blocker used …
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cAMP and Calcium Interactions in Endocrine Cells
… cells were used as a model to test modulation of calcium influx through the L-type calcium channel with PDE inhibitors. cAMP analogs were used to determine cAMP molecular targets. 8-cpt-cAMP initiated an Epac mediated pathway and had strong effects on calcium influx in the cell; suggesting, a …
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Cardiovascular Toxicity Induced by Fumonisin in Pigs and Horses
… compounds which are known to inhibit cardiac L-type calcium channels. We concluded that fumonisin-induced pulmonary edema in swine was caused by acute left-sided heart failure, which was most likely induced by sphingosine-mediated L-type calcium channel blockade. In a subsequent study in horses, …
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Pacemaking Neurons in the study of Parkinson’s Disease
… of motor control. Pacemaking involves the L-type calcium channel, and could impose long-term accumulation of calcium within its organelles. Modelling of this activity is an important part of developing an understanding of the pathogenic process. We develop a mathematical paradigm to describe …
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The Roles of Ca2+ and cAMP in the Nematocyst Discharge of the Sea Anemone Tentacle
… cAMP.</p> <p>We also find that NANA stimulates calcium influx into isolated tentacle ectodermal cells and that the influx is sensitive to various L-type calcium channel blockers, including dihydropyridines. The coincidence of the desensitization region of the nematocyst discharge curve with …
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T-type calcium channels and human mesangial cell proliferation
… of mesangioproliferative renal diseases. The T-type calcium channel (T-CaCN) has been proposed to play an important role in the proliferation of a number of non-excitable cell types, but T-CaCN expression and functional significance in MC is not known. The aim of this thesis was to investigate …
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Proteasome Inhibition As A Potential Anti-Breast Cancer Therapy: Mechanisms Of Action And Resistance-Reversing Strategies
… strategies for the treatment of certain types of cancers. While AMPK serves as a master regulator of cellular metabolism, UPS regulates protein homeostasis. Although the crosstalk between them is suggested, the relationship between these two important pathways is not very clear. We …
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Characterization Of High-Voltage-Activated Calcium Channels In Retinal Bipolar Cells
… parallel pathways through their diversified cell types and physiological properties. Voltage-gated Ca<sup>2+</sup> channels could be particularly important underlying the diversified physiological properties of different BCs. In this dissertation, I investigated the high-voltage-activated (HVA) …