Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"L-type calcium channel"”.
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Oxidant-dependent regulation of L-type calcium channel activity by angiotensin in vascular smooth muscle
… which directly increases peripheral resistance. Calcium influx through voltage-gated L-type calcium channels underlies vascular smooth muscle contraction. Roughly half of calcium influx in these cells occurs through a small number of persistently active channels, whose activity increases with …
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Characterization of L-type Calcium Channel Binding-Site of a new class of Calcium modulators by a Multidisciplinary approach
… ileum longitudinal smooth muscle. Wild-type human heart and rabbit lung α1 subunits were expressed (combined with the regulatory α2δ and β3 subunits) in Xenopus Leavis oocytes using a two-electrode voltage clamp technique. Diltiazem is a benzothiazepine Ca2+ channel blocker used …
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Calciumkanaldichte in humanem ischämischen und reperfundierten, rechtsatrialen Myokardgewebe
Intracellular calcium overload is one of the major pathophysiological mechanisms contributing to myocardial ischemic injury. Two important calcium handling proteins responsible for the maintenance of an intracellular calcium homeostasis are the sarcolemmal voltage-gated L-type calcium channel …
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cAMP and Calcium Interactions in Endocrine Cells
… cells were used as a model to test modulation of calcium influx through the L-type calcium channel with PDE inhibitors. cAMP analogs were used to determine cAMP molecular targets. 8-cpt-cAMP initiated an Epac mediated pathway and had strong effects on calcium influx in the cell; suggesting, a …
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Cardiovascular Toxicity Induced by Fumonisin in Pigs and Horses
… compounds which are known to inhibit cardiac L-type calcium channels. We concluded that fumonisin-induced pulmonary edema in swine was caused by acute left-sided heart failure, which was most likely induced by sphingosine-mediated L-type calcium channel blockade. In a subsequent study in horses, …
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Pacemaking Neurons in the study of Parkinson’s Disease
… of motor control. Pacemaking involves the L-type calcium channel, and could impose long-term accumulation of calcium within its organelles. Modelling of this activity is an important part of developing an understanding of the pathogenic process. We develop a mathematical paradigm to describe …
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The Roles of Ca2+ and cAMP in the Nematocyst Discharge of the Sea Anemone Tentacle
… cAMP.</p> <p>We also find that NANA stimulates calcium influx into isolated tentacle ectodermal cells and that the influx is sensitive to various L-type calcium channel blockers, including dihydropyridines. The coincidence of the desensitization region of the nematocyst discharge curve with …
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T-type calcium channels and human mesangial cell proliferation
… of mesangioproliferative renal diseases. The T-type calcium channel (T-CaCN) has been proposed to play an important role in the proliferation of a number of non-excitable cell types, but T-CaCN expression and functional significance in MC is not known. The aim of this thesis was to investigate …
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Proteasome Inhibition As A Potential Anti-Breast Cancer Therapy: Mechanisms Of Action And Resistance-Reversing Strategies
… strategies for the treatment of certain types of cancers. While AMPK serves as a master regulator of cellular metabolism, UPS regulates protein homeostasis. Although the crosstalk between them is suggested, the relationship between these two important pathways is not very clear. We …
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Characterization Of High-Voltage-Activated Calcium Channels In Retinal Bipolar Cells
… parallel pathways through their diversified cell types and physiological properties. Voltage-gated Ca<sup>2+</sup> channels could be particularly important underlying the diversified physiological properties of different BCs. In this dissertation, I investigated the high-voltage-activated (HVA) …