Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"L-type Ca2+ channel"”.
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The Role of Synaptically Evoked Plateau Potentials in Retinogeniculate Development
… high-amplitude depolarizations mediated by L-type Ca2+ channel activation, plateau potentials. Plateau activity prevails early in life, at the peak of retinogeniculate refinement, however, little is known about the factors that contribute to the activation of these events, or the potential …
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Zur Drucksensitivität der Kanalfunktion vestibulärer Haarzellen Typ II
… are inhibited by charybdotoxin, an inhibitor of Ca2+ dependent K+ channels. Furthermore cinnarizine is an inhibitor of voltage-gated Ca2+ currents in hair cells and is used as a drug in condition with vestibular vertigo. An aim of the presented experiments was to test, whether cinnarizine …
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Vascular Kv7 (KCNQ) Potassium Channels As Therapeutic Targets in Cerebral Vasospasm
… wall, leading to continuous influx of calcium (Ca2+) through voltage-sensitive Ca2+ channels (VSCC) resulting in hyperconstriction (spasm). The spasm of the arteries restricts blood flow to the brain, inducing ischemic neurological deficits and consequential high morbidity and mortality. The …
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Functional, Structural and Molecular Alterations in the Heart and Kidney During Diabetes Mellitus
… retinopathy and neuropathy that are common in type 1 DM (T1DM) and type 2 DM (T2DM). Epidemiological studies have demonstrated a role of hyperglycaemia (HG) in eliciting adverse cardiac and renal outcomes including heart failure (HF), diastolic and renal dysfunction. This study investigated the …
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The Role of the TBX5-driven Regulatory Network in the Manifestation and Sustainability of Atrial Fibrillation
… both spatial-temporal and structural aspects of Ca2+ handling are further adapted and utilised in this thesis. In this thesis, I first developed a biophysics-based model of the human atrial myocyte that is capable of reproducing early and after/spontaneous depolarization (EADs and DADs/SDs) by …
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Role of two genes, CACNA1D and CADM1, with common or rare mutations in aldosterone producing adenomas of the adrenal.
… ATP1A1, ATP2B3 and CACNA1D, all encoding cation-channels or transporters. Several in vitro studies showed disruption of cellular ion-balance leading to the phenotype of hyper-aldosterone secretion from APAs. Following our lab’s discovery of initial four somatic mutations by whole exome …
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Regulation of glucagon secretion from pancreatic alpha cells
… excitable and equipped with different ion channels. But unlike β-cells, α-cells electrical activity is only possible within a narrow window of low K(ATP) channel activity. At low glucose, the K(ATP) channels are almost fully – but not completely –inhibited. This allows firing of action …