Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"L-serine"”.
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Profiling L-serine Transport Throughout Growth and Meiotic Maturation in Mouse Oocytes
… nutrients. This thesis focuses on the amino acid serine, which has been shown to improve outcome in developing embryos and also plays a variety of roles in the body that may carry over to oocyte health as well. Using radiolabeled [3H] serine, we measured uptake of serine as a function of time …
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The relationship between docohexanoic acid (DHA) and L-serine, providing an insight into the biochemistry of meningioma
… unusually high levels of the phosphatidylserine enriched with docosahexaenoic acid (DHA). In this study, the metabolism surrounding lipid biosynthesis was examined to establish if such alterations in lipid profiles were related to an altered state of metabolism. From the results gained, it …
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Escherichia coli mutants unable to use a combination of L-serine, glycine and L-leucine as carbon source
Previously, medium containing a combination of L-serine, glycine and L-leucine (SGL medium) has been used to study the characteristics, including the activation system, of L-serine deaminase (L-SD), an interesting enzyme from Escherichia coli that is first synthesized in an inactive form. In this …
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Untersuchungen zur L-Serin-Bildung mit Corynebacterium glutamicum
L-serine is a very important precursor of many cellular metabolites with a central position in the metabolism of corynebacterium glutamicum. This is especially because of the reaction catalyzed by the serine hydroxymethyltransferase (SHMT) in which serine is degraded to glycine and a C1 unit. It …
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I The synthesis of papyracillic acids: Application of the tandem chain extension-acylation reaction II Diastereoselective synthesis of beta-methyl-gamma-keto esters through the utility of an L-serine auxiliary
… esters were achieved through the utility of an L-serine auxiliary. Preparation of a series of L-serine derived precursors were prepared and studied.</p>
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Small Phosphomonoesters as Probes of Protein-Tyrosine Phosphatase Active Sites
… also were challenged in vitro with free phosphoserine. Each displayed little or no activity towards free phosphoserine. However, the addition of a hydrophobic "handle" to form N-(cyclohexane carboxyl)-O-phospho-L-serine produced a derivative that was hydrolyzed by IphP at rates comparable to …
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Molecular studies of the sdaA and sdaB genes and their gene products in Escherichia coli K-12
… the existence of Escherichia coli K-12 of two L-serine deaminating enzymes, L-serine deaminase (L-SD)#1 and L-SD#2. It demonstrates that the structure of L-SD#1 is coded by the sdaA gene, which has been cloned and sequenced. The entire sdaA gene was fused to the lacZ gene by mutating the …
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Vascular action of glycine in hypertensive rat models
… non-essential amino acid biosynthesized from L-serine, L-alanine and L-threonine, plays a role in the biosynthesis of proteins, nucleotides, and glutathione. It is a neurotransmitter in the central nervous system and acts as a co-agonist at the N-methyl-D aspartate (NMDA) receptor. Oral …
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Addressing the ongoing threat of antimicrobial resistance: synthetic investigations of novel amicetin and B-lactam antibiotics
… of p-aminobenzoic acid (PABA)--methyl-L-serine substructure of amicetin, from PABA as the starting point. Synthetic access to the PABA--methyl-L-serine moiety would allow for structure-activity relationship (SAR) studies to be performed on the natural antibiotic. This synthetic route …
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Dynamic charge densities of amino acids and proteins
… K) high-resolution data sets of α-glycine, D,L-serine, L-alanine and L-alanyl-L-tyrosyl-L-alanine (Ala-Tyr-Ala) as well as the protein Crambin (T = 100 K). By using a multi-temperature data set of D,L-serine, the effect of temperature on electron densities have been analyzed. Density values near …
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Synthetic Alkyl Glycolipids as Therapeutic Agents: Their Synthesis as Potential iNKT Cell Stimulators and their Anti- Microbial Properties
… acid based glycolipids, glycoglycerolipids and L-serine based glycolipids were explored. Simple galactosyl glycolipids containing O- and N-glycosidic linkages and L-aspartic acid based glycolipids were constructed as in Chapter 2 with a view to test their anti-microbial properties against cystic …
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In Vitro Methanogenesis From Formaldehyde. Identification of Three Carbon-1 Intermediates of the Methanogenic Pathway
… thiazolidine, hexamethylene-tetramine, and L-serine required FAF for their conversion to CH(,4). HCHO was found to react chemically with FAF to form methylene-FAF. HOCH(,2)-S-CoM, thiazolidine, and hexamethylenetetramine were found to be in equilbrium with HCHO. This equilibrium was found to …
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In vivo study of the expression of the genes serA and gltD regulated by Lrp (Leucine-responsive regulatory protein) in Escherichia coli K-12
… gene, a decrease in expression was observed as L-serine (500 $\mu\rm g/ml)$ was added to glycerol minimal media.
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Insulin based analogs HLVEALYLV and LVEALYLV to inhibit the formation of amyloid fibrils in beta cells
… (DOPC) and 1,2-dioleoyl-sn-glycero-3- (phospho-L-serine) (DOPS), respectively, and the percent leakage of fluorescent dye from the vesicles in the presence of the peptides was calculated as compared to a 100% Triton-X detergent-treated control. The activity of the truncated analogs was compared to …
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The Development and Characterization of Scaffolded Vesicles as a Model Membrane
… 10 mol% 1,2-diphytanoyl-sn-glycero-3-phospho-L-serine (DPhPS), and a DMPC, cholesterol, ganglioside GM1 membrane in a 40:30:30 DMPC:cholesterol:GM1 molar ratio. Each of these scaffolded vesicles were characterized using ATR-IR spectroscopy, fluorescence microscopy, fluorescence quenching, …
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Formation of 4(5)-methylimidazole in processed meat and in glucose amino acid model system
… [subscript]L-Lysine (Lys), and [subscript]L-Serine (Ser); and the mixtures were heat treated at 60, 120, and 160°C for 1 h. Among all tested amino acids, Glu-Arg produced the highest level of 4-MeI. The Glu-Lys model system showed higher browning and lower concentrations of 4-MeI. The effect …
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GPR55 and N-acyl Amino Acids
… of N-acyl amino acids; possessing either a serine or glycine head group attached to varying fatty acid chains; to assess these novel lipids as potential GPR55 ligands. Three cell lines were utilised, a stably transfected HEK293 cell line that overexpresses 3xHA N-terminus tagged hGPR55 …
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Contribution of different types of phospholipids in blood coagulation
… take place on membranes with exposed phosphatidylserine (PS). GLA domains are the most common PS-binding motifs in blood coagulation. A further intriguing aspect of the membrane’s contributions to clotting is that phosphatidylethanolamine (PE) supports little or no clotting activity in the absence …
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Characterization of ceramide synthases (Cers) in mammalian cells
… from utilization of L-alanine instead of L-serine by serine palmitoyltransferase (SPT) based on the inability of LYB cells, which lack SPT, to make 1-deoxysphinganine. In the absence of FB1, 1-deoxysphinganine is primarily acylated to 1-deoxydihydroceramides. These are an underappreciated …
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The Synthesis and Characterisation of Novel Low Molecular Weight Gelators and their Applications in Electrospinning to Develop Biocompatible Materials and Tissue Scaffolds
… characterisation of amphiphilic derivatives of L-serine and their evaluation as LMWGs. This study shows how structural features, such as the functional groups in the side chain, or the length of the hydrocarbon chains affect their ability to form gels. These compounds were found to effect …
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