Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"L-leucine"”.
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The acute effects of l-Leucine and l-Isoleucine on glycemic responses in healthy and inactive adults
… the “priming” effect of pre-ingested L-Isoleucine (ISO) and L-Leucine (LEU) on glucose metabolism and glycemic hormones in healthy, inactive adults. We hypothesized that preingested ISO and LEU would diminish the post prandial rise in glucose prior to a 75 g oral glucose tolerance test …
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Escherichia coli mutants unable to use a combination of L-serine, glycine and L-leucine as carbon source
… a combination of L-serine, glycine and L-leucine (SGL medium) has been used to study the characteristics, including the activation system, of L-serine deaminase (L-SD), an interesting enzyme from Escherichia coli that is first synthesized in an inactive form. In this thesis, I isolated two …
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Dipeptides as potential anti-flammatory drugs for rheumatoid arthritis
… four glycine peptides (glycyl-glycine, glycyl-L-leucine, glycyl-L-phenylalanine and glycyl-L-histidine) and four sarcosine peptides (sarcosylglycine, sarcosyl-L-leucine, sarcosyl-L-phenylalanine and sarcosyl-L-histidine) have been studied using glass electrode potentiometry and isothermal …
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Modeling Diamond-Blackfan Anemia in the Mouse: Disease Pathogenesis and Evaluation of Novel Therapies
… the therapeutic potential of the amino acid L-leucine in the treatment of DBA. We show that L-leucine treatment improves the anemia and alleviates the stress hematopoiesis in Rps19-deficient mice. In article III we evaluated the therapeutic efficacy of gene therapy using our mouse models for …
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In vivo study of the expression of the genes serA and gltD regulated by Lrp (Leucine-responsive regulatory protein) in Escherichia coli K-12
… were more sensitive to Lrp than that of gltD. L-leucine's effects on Lrp's function were also investigated. Adding L-leucine to the minimal media decreased Lrp's activation of both serA and gltD. As for the plasmid-carried lrp gene, a decrease in expression was observed as L-serine (500 $\mu\rm …
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The formation of isovaleraldehyde from ℓ-leucine and isobutyraldehyde from ℓ-valine catalyzed by banana polyphenoloxidase and peroxidase
… for the formation of isovaleraldehyde from l-leucine and isobutyraldehyde from l-valine in bananas are described. These aldehydes are key intermediates for the development of the branched-chain alcohols and esters, which are prominent components of banana flavor volatiles. When amino acids …
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The Effect of Heavy Metals on the Uptake of L-Histidine by the Polychaete Nereis Succinea
… (P > 0.05) altered amino acid influx. L-Leucine (25 uM) reduced Zn2+ -stimulated L-Histidine influx, suggesting a possible role of the Na-independent L-transport system in metal-stimulated L-Histidine transport by worm integument.
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Determination of L- and D-methionine and L- and D-valine in soy isolate and soy flour samples
… and two soy isolate samples were coupled with L-leucine-N-carboxyanhydride. If both D- and L-forms were present this would produce diastereomeric dipeptide derivatives. The derivatives were separated by ion-exchange chromatography using a TSM Amino Acid Analyzer. Comparison of the sample …
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Characterization of a mutation demonstrating a link between the lack of S-adenosylmethionine and cell division in Escherichia coli
… medium require the presence of 50 $\mu$g/ml L-leucine. When the leucine concentration is reduced to 25 $\mu$g/ml or less, cells fail to divide, resulting in the formation of long filaments. These filaments can undergo DNA replication, but fail to form crosswalls. SAM synthetase activity assays …
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Structures of the Didemnins (Antiviral, Antitumor, Compounds)
… compounds, contains one mole each of N-methyl-D-leucine (MeLeu), L-threonine (Thr), 3S,4R-statine (Sta), L-leucine (Leu), L-proline (Pro), and N,O-dimethyl-L-tyrosine (Me(,2)Tyr), and a 2R,4R-hydroxyisovalerylpropionyl (Hip) group. Didemnins B-E differ from didemnin A by acylation of the …
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Crosstalk of TTC5 cofactor and the estrogen receptor in breast cancer
… such as breast cancer.ER, through L-X-X-L-L (L=leucine, X=any amino acid) motifs, interacts with cofactorssuch as TTC5 (tetratricopeptide repeat domain 5) which is a 440 amino acid protein,predicted to have 6 TPR (tetratricopeptide repeat) motifs and 4 LXXLL motifs, which areknown to mediate …
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Determining the Rates of Protein Synthesis in the Zebrafish Heart in Response to Chronic Unpredictable Stress
… a stable isotope-labelled amino acid ([2H7] L-leucine) via the diet and its incorporation into heart proteins was monitored over an 8 week time course. Using this method it was possible to calculate the synthesis rates of over 600 proteins. The experimental strategy was then applied to define …
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Role of Flagellar Motility in Apple Blossom Invasion and Tactic Response to Various Plant Nectar Extracts by Erwinia Amylovora
… and appears to be inducible for L-isoleucine, L-leucine and L-phenylalanine. Benzoate and salicylate were used as repellents while malate and tartarate were used as attractants in field trials. None of these compounds applied to apple blossoms as 1 or 10 nM solutions provided …
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Methodological and biological studies of the amino acid oxidases.
… EC 1 .4.3.2.) assay which utilized L-leucine as substrate (Km 0.6 mmol 1 ) at a concentration of 3.3 mmol 1[-1]. This concentration of substrate was low enough to avoid any significant effect of substrate inhibition and yet permitted 85% of the maximum velocity. The oxidation of NALH …
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Mechanisms of chloride modulated activity in the C-domain of angiotensin-converting enzyme
… short synthetic substrates hippuryl-L-histidyl-Lleucine (HHL) and Z-phenylalanyl-L-histidyl-L-leucine (Z-FHL) under differing chloride concentrations. An isothermal titration calorimetry-based assay was developed to determine the effect of chloride concentration on enzyme thermodynamic and …
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DRY POWDER INHALATION OF PNEUMOCOCCAL VACCINE USING POLYMERIC NANOPARTICLES AS CARRIERS
… nanocomposite microparticles (NCMPs) using L-leucine (L-leu) to be delivered via inhalation was developed. Poly(glycerol adipate-co-ω-pentadecalactone), PGA-co-PDL, NPs with either anionic or cationic surface charge of optimum size (~200-250 nm) to be effectively taken up by the lung dendritic …
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PULMONARY DELIVERY OF RESVERATROL-LOADED NANOCOMPOSITE MICROPARTICLES TO TREAT LUNG CANCER
… nanocomposite microparticles (NCMPs) using L-leucine and chitosan were developed for the pulmonary delivery via dry powder inhalation. Resveratrol was loaded into NPs of poly(glycerol adipate-co-ω-pentadecalactone) (PGA-co-PDL) with sizes ranging between 220-230 nm, which are ideal for uptake …
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MicroRNA Nanocarriers for the Treatment of Chronic Obstructive Pulmonary Disease
… This was followed by spray-dying using L-leucine and mannitol to prepare dry powder nanocomposite microparticles (NCMPs) for pulmonary delivery. Anionic and cationic poly (glycerol adipate-co- ω-pentadecalactone), (PGA-co-PDL), NPs were produced using poly (vinyl alcohol) and …
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The Oxidative Deamination of Sulfur Amino Acids by a Bacterial L-Amino Acid Oxidase
… here the enzyme catalyzes the oxidation of L-leucine, L-phenylalanine, L-tryptophan, L-arginine, L-tyrosine, L-histidine, L-ornithine, L-citrulline, L-lysine and L-isoleucine with a pH optimum at 7.5. Specific activity, pH optimum, K<sub>m</sub> and V<sub>max</sub> values were determined for …
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PULMONARY DELIVERY OF PNEUMOCCOCAL VACCINE USING NANOCOMPOSITE MICROPARTICLE CARRIERS VIA DRY POWDER INHALATION
… were incorporated into microcarriers using L-leucine and spray dried to produce nanocomposite micro#particles (NCMPs) dry powder for inhalation. Parameters for the preparation of protein-loaded polyester poly (Glycerol Adipate-co-ω-Pentadecalactone), (PGA-co-PDL) NCMPs were optimised using …
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