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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"L-lactide)"”.
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Functional Self-Assembled Poly (L-Lactide) Nanoparticles For Targeted Delivery of Bioactive Agents
… cancer therapy.</p> <p>In the first part, poly(lactide-co-glycolide) fumarate (PLGF) NPs were used for the delivery of recombinant human bone morphogenetic protein-2 (rhBMP-2) and a peptide isolated from the BMP-2 protein. They were encapsulated in or grafted to the NPs for their sustained …
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Fundamental Studies of Various Poly(L-lactide)/clay Nanocomposite Systems by in-situ Polymerization
… In this study, in situ polymerizations ofpoly(L-lactide)-clay nanocomposites were conducted using various montmorillonite organoclays (PLLA-MMT). When using tin (Il) 2-ethylhexanoate (Sn(Oct)2) as the catalyst, the reaction is believed to initiate from stannous alkoxides, formed from hydroxide …
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The Degradation and Drug Release Mechanisms of Poly(ethylene glycol)-functionalised Poly(L-lactide) Polymers
Poly(L-lactide) (PLLA) is a well-recognised bioresorbable polymer known to degrade after 1.5 to 5 years by hydrolysis. For certain medical device or drug delivery applications, it would be desirable to reduce this degradation time as strategies for tailoring degradation and drug release rates …
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Synthesis and Characterization of Polylactide-siloxane Block Copolymers as Magnetite Nanoparticle Dispersion Stabilizers
Polylactide-siloxane triblock copolymers with pendent carboxylic acid functional groups have been designed and synthesized for study as magnetite nanoparticle dispersion stabilizers. Magnetic nanoparticles are of interest in a variety of biomedical applications, including magnetic field-directed …
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Amorphous, multi-phase polymer network systems with shape memory properties by photopolymerization
… In the polymer network system from oligo[(L-lactide)-ran-glycolide] segments, it is possible to obtain materials with different mechanical, but equal thermal properties just by varying the molecular weight of the network precursor. Cyclic, thermomechanical measurements which keep the network …
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Preparation and Characterization of Electrospun Poly(D, L-Lactide-Co-Glycolide) Scaffolds for Vascular Tissue Engineering and the Advancement of an In Vitro Blood Brain Barrier Model
<p>Developing an <em>in vitro</em> Blood Brain Barrier model that will replicate the physiological, anatomical, and functional characteristics of the native BBB has gained significant attention. Such a model would enable prediction of the penetration of CNS targeting drug candidates across the BBB, …
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Freisetzungsverhalten von unterschiedlich hydrophil/hydrophoben Modellsubstanzen aus Poly-(D,L-lactid)- und Poly-(D,L-lactid)-co-PEO-co-poly-(D,L-lactid)-Mikrosphären und pharmazeutische Anwendungen
… substances and drugs from degradable poly-(D,L-lactide) (PDLLA) and poly-(D,L-lactide)-co-PEO-co-poly-(D,L-lactide) (ABA) microspheres as well as poly-(D,L-lactide-co-TMC)(90:10) nanospheres in PBS-buffer are characterised. To investigate the release behaviour, three different …
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Entwicklung einer biodegradierbaren Harnleiterschiene : In-vitro-Analytik von Poly(D,L-Lactid) als Homo- und Copolymer, Formgebungs-Technologie, Oberflächenmodifizierung und tierexperimentelle Untersuchung im Schaf-Modell
… a biodegradable ureteric stent, various polylactides were analyzed and grafted with a clinically adapted surface. Stent moulding was performed by CESP-technology (Controlled Expansion of Saturated Polymers), which is not based on high temperature but gas-loading under high pressure which …
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Interactions between adult human mesenchymal stem cells and nanofibrous scaffolds of different compositions
… matrix. One is derived solely from Poly-L-lactide acid and the other from Poly-L-lactide/Gelatin (50:50). Before and after culturing, measurements of fiber diameter, thermodynamics, and tensile strength were collected. Studies with primary human MSCs were conducted to characterize the in …
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Studien zur kontrollierten Freisetzung biologisch aktiver Substanzen aus resorbierbaren Nano- und Mikrosphären
… endocyosis. Commercially available poly(D,L-lactide) (RESOMER R 208) and poly(D,L-lactide-co-glycolide) 50:50 (RESOMER RG 504) were used as materials, both of which have a history of biomedical applications. The controlled release of bioactive substances in scaffolds for the tissue …
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Synthesis, Characterization and Structure-Property Relationships of Polymer-Stabilized Nanoparticles Containing Imaging and Therapeutic Agents
… block copolymer, poly(ethylene oxide-b-D,L-lactide) were fabricated by a scalable, rapid precipitation technique using a multi-inlet vortex mixer. Quantitative control over iron oxide loading, up to 40 wt%, was achieved. Correlations between particle parameters and transverse relaxivities …
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Synthesis and Characterization of Poly(lactide) Functional Oligomers and Block Copolymers
… consisting of poly(ethylene oxide) and poly(lactide) have great potential for formulating drug delivery systems. Our approach was to synthesize poly(ethylene oxide-b-D,L-lactide), (PEO-b-PDLLA), block copolymers with controlled molecular weights and good functionality on the poly(ethylene …
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Load bearing regenerative repairs for the cartilaginous soft tissue of the intervertebral disc
… weight acrylated star-copolymers composed of D,L-lactide or trimethylene carbonate with caprolactone were mixed with an aqueous solution of methacrylated glycol chitosan to form a hydrogel-elastomer co-continuous morphology. After photo-cross-linking, the elastomer phase contributed the majority …
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Preparation and Functionalization of Macromolecule-Metal and Metal Oxide Nanocomplexes for Biomedical Applications
… The surface amine groups can initiate L-lactide and the biodegradable polymer, poly(L-lactide), can be polymerized directly from the surface. The protected cobalt surface can also be re-functionalized with poly(dimethylsiloxane) and poly(ethylene oxide-co-propylene oxide) providing …
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Biodegradable Thermoplastic Elastomers and Smart Composites
… Increasing the comonomer (glycolide or d,l-lactide) content caused a decrease in the thermal and mechanical properties, while increasing POSS caused an increase in these properties. Overall, the synthesized polyurethanes had low moduli, high strain-to-failure, and high elasticity. </p> <p>In …
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Induktion und Prophylaxe Implantat assoziierter Knocheninfektionen am Modell eines antiinfektiv beschichteten Marknagels
… antibacterial gentamicin-loaded poly-(D,L-lactide) (PDLLA) coating of orthopedic devices. In vitro, elution kinetics of gentamicin and furthermore, biocompatibility and effectiveness in preventing implant-related osteomyelitis should be studied in vivo. Coating of commercial steel implants …
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In vitro inflammatory response evaluation of pre-degraded bioresorbable polymers
Bioresorbable polymers composed of poly(lactide), poly(glycolide) and their related copolymers have become increasingly popular in the biomedical field, and especially for the preparation of bone substitute constructs. However, there are reports of a delayed inflammatory reaction occurring months …
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Fabrication of nanofiber scaffolds by electrospinning and it's potential for tissue engineering
… size ranges composed of non-woven poly-L-lactide (PLLA) nanofibers and as a first study, the potential use of these scaffolds as tissue engineering scaffolds was assessed with the cell proliferation of Mesenchymal stem cells. Electrospun fibers were characterized for fiber diameter, …
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Development of particle-based systems for the delivery of oligonucleotides into primary dendritic cells
… of condensates. Nanoparticles of poly (d, l-lactide-co-glycolide) are biodegradable particulates that provide the ability to entrap O10H6-ODN condensates and protect DNA. These particles loaded with DNA condensates were also shown to enhance delivery of ODN to DCs. The ability of ODN to …
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