Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"L-histidine"”.
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The Effect of Heavy Metals on the Uptake of L-Histidine by the Polychaete Nereis Succinea
Integumentary uptake of 3H-L-Histidine by Nereis succinea was measured in the presence and absence of selected heavy metals and inhibitors in 60% artificial seawater (ASW). At low concentrations of L-Histidine (10 uM), metals stimulated L-Histidine uptake from ASW. Higher concentrations of metal …
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Project Synthesis of N Acetyl L Histidine Ethyl Amide and Standard Operating Procedure for Fractional Collector
… Studies show that tryptophan, tyrosine and histidine side chains gives rise to semi stable peroxides on exposure to singlet oxygen these oxidized structures are studied with low temperature NMR. These peroxides or species derived from them have been postulated as key intermediates in …
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Development of copper based anti-inflammatory drugs: histodine derivatives
Methyliminodiacetylhistidine dimethyl ester could not be synthesised. However the other two ligands, glycine and glycyl-L-histidine were purchased and used for this study. The equilibrium constants of the ligand (glycyl-L-histidine) and the ligand complexes with Cu(II), Ni(II) and Zn(II) were …
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Novel imprinted polymers as artificial enzymes
Derivatives of L-histidine were investigated as suitable models for the Asp-His couple found in the catalytic triad of serine proteases. A combination of molecular dynamics and IH NMR spectroscopy suggested that the most populous conformations of N-acetyl-L-histidine and the N-acetyl-L-histidine …
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Novel nutritional interventions in the manipulation of energy expenditure and blood glucose regulation in humans
… metabolic effects of two dietary agents, L-Histidine and Epigallocatechingallate (EGCG). Supplementation of both LHistidine and pure EGCG in animal models has previously shown effects on components of energy balance and blood glucose regulation. Studies of their supplementation among humans …
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Dipeptides as potential anti-flammatory drugs for rheumatoid arthritis
… glycyl-L-phenylalanine and glycyl-L-histidine) and four sarcosine peptides (sarcosylglycine, sarcosyl-L-leucine, sarcosyl-L-phenylalanine and sarcosyl-L-histidine) have been studied using glass electrode potentiometry and isothermal titration calorimetry at 25 °C and an ionic strength …
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Carnosine’s inhibitory effect on glioblastoma cell growth is independent of its cleavage
… and tissue carnosinase (CN2). The amino acid L-histidine is supposed to be mainly responsible for the dipeptides physiological properties based on its imidazole moiety. Among the physiological properties ascribed to the dipeptide are its ability to scavenge reactive oxygen species and to protect …
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Development of copper peptide complexes as anti-Inflammatory drugs
… sarcosyl-L-histidyl-L-lysine, sarcosyl-Llysyl- L-histidine, sarcosyl-L-histidyl-L-histidine, sarcosyl-L-lysyl-L-lysine and sarcosyl-Lglycyl- L-histidine. Equilibrium constants of H+, Cu(II), Ni(II) and Zn(II) with the peptides were measured in aqueous solution at 25±0.01oC and an ionic strength of …
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The proton-coupled oligopeptide transporters PEPT2, PHT1 and PHT2 mediate the uptake of carnosine in glioblastoma cells
… demonstrated that carnosine (β-alanyl- L -histidine) inhibits the growth of tumor cells in vitro and in vivo. Considering carnosine for the treatment of glioblastoma, we investigated which proton-coupled oligopeptide transporters (POTs) are present in glioblastoma cells and how they …
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Terpyridine Functionalized Dye-Doped Silica Nanoparticles (DDSN) for Detection of Metal Ions
… is returned upon the introduction of EDTA, L-histidine, and epinephrine, the fluorescein dye in our system may interact with many of the anions tested.</p>
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CHEMICAL AND KINETIC STUDIES OF BACTERIAL TRANSPORT AND CHEMORECEPTOR PROTEINS
… the L-arabinose-, D-galactose-,D-maltose- and L-histidine-binding proteins were examined by stopped flow rapid mixing techniques. The change in tryptophan fluorescence that occurs in these reactions is adequately described in all cases by a rapid second order process, no additional phases of …
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Development of dermally absorbed copper(ii) complexes as potential anti-inflammatory drugs
… inflammation. The tripeptides, glycyl-L-leucyl-L-histidine (GLH), sarcosyl-L-leucyl-Lhistidine (Sar-LH), glycyl-L-phenylalanyl-L-histidine (GFH) and sarcosyl-L-phenylalanyl-Lhistidine (Sar-FH) were designed to resemble the natural in vivo copper(II) transporter, human serum albumin, so that they …
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Total electron scattering cross sections of molecules containing H, B, C, N, O, F, Si, P, S, and Cl in the energy range 0.1- 6.0 keV.
… and simple amino acids (Glycine, Lysine and L-histidine) in the energy range 0.1-6.0 keV are predicted using the model. The reliability of these predictions are verified by comparing the determined TCS with the available experimental and theoretical cross sections.
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Synthesis and Evaluation of Trans-bilayer Cross Linking Phospholipids Based on Click (Azide-Alkyne) Chemistry
… buffer solution and exposed to copper catalyst/L-histidine complex and sodium ascorbate solution at room temperature. Formation of bola-PC were observed in the hydrophobic core of lipid bilayer and this was the main objective of this study.
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Structure-function studies of SLC15 peptide transporters
… well as sequence homology. Finally, rat peptide histidine transporter (ratPHT1, SLC15A4), has been reported to transport L-histidine in addition to di- and tri- peptides, and to be expressed on the neuronal lysosomal membrane. Surface expression studies of FLAG epitope tagged PHT1 protein …
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Synthesis and modification of pamam dendrimers as histone replacement molecules
… of novel small molecules based around L-histidine and photo-responsive azobenzene, and the use of these to modify the surface of 4th and 5th generation PAMAM dendrimers is reported in Chapters 4 and 5 respectively. There follows a final chapter containing detailed descriptions of the …
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The use of ion pairs to increase the percutaneous delivery of diclofenac
… partitioning from aqueous to organic phases. L-histidine hydrochloride monohydrate (LHSS) was identified as optimal, a finding validated through porcine skin in vitro permeation testing (IVPT). Next, solubility challenges were addressed by assessing diclofenac sodium (DNa) solubility in various …
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Carnosine metabolism and function in the thoroughbred horse
… the contractile process. Carnosine (ß-alanyl-L-histidine, pK<sup>a</sup> 6.83) occurs at high concentration in equine muscle where it functions as an effective H<sup>+</sup> ion buffer at physiological pH. <br></br><br></br> High-performance liquid chromatography analytical methods were …
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Genetic effect of histamine N-methyltransferase (HNMT) polymorphism on chronic urticaria with aspirin hypersensitivity
… are regulated by histamine synthesis enzyme, L-histidine decarboxylase (HDC), and two metabolizing enzymes, histamine N-methyltransferase (HNMT) and diamine oxidase (DAO). Especially, the presence of HNMT genetic polymorphisms might results in reduced histamine metabolism and may influence the …
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