Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"L-cell"”.
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Characterisation of L-cell secretory mechanisms and colonic enteroendocrine cell subpopulations
Enteroendocrine cells (EECs) are chemosensitive cells of the gastrointestinal epithelium that exert a wide range of physiological effects via production and secretion of hormones in response to ingested nutrients, bacterial metabolites and systemic signals. Glucagon-like peptide-1 (GLP-1) is one …
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Characterization of lignin deposition in <i>Pinus taeda</i> L. cell suspension cultures
<i>Pinus taeda</i> L. suspension culture cells were used to develop a model system to study the process of lignification occurring during the early stages of cell wall formation and maturation. Chemical, biochemical and histochemical analyses of the <i>P. taeda</i> suspension cultures grown with …
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Characteristics of sodium transport through the amiloride-sensitive sodium-magnesium pathway in hamster red cells
In hamster red cells, amiloride-sensitive Na influx, 0.8 mmol/l cell/hr, is the only, carrier-mediated, Mg-dependent pathway for inward Na transport. This Na-dependent Mg transport is involved in the regulation of intracellular Mg$\sp{2+}$ concentration under physiological conditions.
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Circadian Secretion of Glucagon-like Peptide-1
… tissues, which have been found to express cell-autonomous clocks that are entrained by food intake, are largely responsible for establishing diurnal metabolic homeostasis. The incretin hormone glucagon-like peptide-1 (GLP-1) enhances glucose-stimulated insulin secretion following nutrient …
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Maintenance of Genomic Integrity by RSF1 Chromatin Remodeler
… I. INTRODUCTION 2 II. MATERIALS AND METHODS 4 A. Cell culture and treatments 4 B. Generation of RSF1 KO cells 4 C. Transfection and RNA interference 4 D. Plasmid and purification of recombinant proteins 5 E. Immunoprecipitation and in vitro binding assay 5 F. In vitro kinase assay 6 G. Cell …
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Pre-, pro-, and synbiotic modulation of the intestinal microbiota stimulates enteroendocrine mediated intestinal adaptation in piglets with short-bowel syndrome
… higher secretion of GLP-2 from enteroendocrine L-cells. Hence, manipulation of the intestinal microbiota is a logical target for the treatment of NEC and SBS, given its ability to produce butyrate and other SCFA through microbial syntrophy. In this series of studies, we: 1) Identified key existing …
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G-Protein Coupled Receptors Modulating Incretin Hormone Secretion
… glucagon-like peptide-1 (GLP-1), secreted from K-cells and L-cells respectively, augment insulin secretion. In addition, GIP facilitates triglyceride storage and GLP-1 has anorexic effects. Incretins are released from the gastrointestinal tract in response to food ingestion. Great interest exists …
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Butyrate-Induced Expression of Proglucagon: Implications for Enteroendocrine Signaling and Intestinal Growth
… are a number of different types of endocrine cells in the gut which have the ability to mediate nutrient-gene interactions. Of interest for this research is the L cell of the distal ileum and colon which expresses the proglucagon gene. Proglucagon encodes a number of important hormones, namely …
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Butyrate-induced expression of proglucagon: implications for enteroendocrine signaling and intestinal growth
… are a number of different types of endocrine cells in the gut which have the ability to mediate nutrient-gene interactions. Of interest for this research is the L cell of the distal ileum and colon which expresses the proglucagon gene. Proglucagon encodes a number of important hormones, namely …
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The chemical characterisation of authigenic carbonates from the Witbank no. 2 coal seam : environmental and diagenetic implications
… coal seam in the Witbank basin. These are: l) cell-filling carbonate, 2) early formed spberulites, 3) massive carbonates, 4) cleat-filling carbonate, 5) fracture-filling carbonates and 6) carbonate cement of associated sands. The textural relationships, depth of burial and chemical evolution of …
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Butyrate-induced upregulation of intestinal glucose transport and signaling pathways represent a possible nutrient therapy for individuals with malabsorptive disorders
… through stimulation of enteroendocrine L-cells by butyrate were examined. The initial studies used Caco2-BBE monolayers as an in vitro model for the human intestine to test for the upregulation of GLUT2 mRNA abundance by butyrate and other SCFA. Next, the impact of butyrate on glucose …
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Manipulating proglucagon processing in the pancreatic alpha-cell for the treatment of diabetes
… and glucagon secretion, and promotion of beta-cell survival and proliferation. GLP-1 is produced in the intestinal L-cell via processing of the proglucagon precursor by prohormone convertase (PC) 1/3. Proglucagon is also expressed in the pancreatic alpha-cell; however, in this tissue PC2 is …
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Effects of psychoactive trace minerals on glial cell development in vitro.
… interact with lithium to affect glioblastoma cell proliferation, function and viability in vitro. Two different glioblastoma cell lines (U87M0 and 132 1N1) were cultured in media containing different concentrations of either zinc or copper above and below the physiological range (0.02 to 10 …
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Stimulus-Section Coupling in Endocrine Cell Models
… Stimulus-secretion coupling in hormone secreting cells is a complex system of pathways that link activation of cellular processes by i.e. nutrients to the release of hormone. Stimulus-secretion coupling in the insulin secreting beta-cell is intensely researched to improve our understanding of type …
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Exploring glucagon-like peptide 1-secreting L-cells as signal transducers in the microbiota-gut-brain signalling pathways
… for their numerous health benefits. L-cells are located at the intersection of the gut barrier, and the host endocrine and neural systems. As such, these cells may act as signal transducing cells by releasing GLP-1 basolaterally following stimulation by nutritional, microbial, or liver …
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Characterisation of human enteroendocrine cells in organoid models
Gut hormones secreted by enteroendocrine cells (EECs) coordinate the postprandial response to a meal by regulating digestion, absorption, circulating nutrient availability and satiety. EECs are specialised endocrine cells scattered throughout the gastrointestinal epithelium that release hormones in …
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Transcriptional regulation of the human alpha 2(I) procollagen gene
… objective of this study was to investigate the cell- and species-specific regulation of the α2(1) pro collagen gene by analysing trans-acting factor interactions within the proximal promoter of the gene and to identify the genes coding for these trans-acting factors. α2(1) procollagen gene …
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Optimization of Cell Culture Procedures for Growing Neural Networks on Microelectrode Arrays
… It is presented as a guidebook for use by cell culture specialists and laboratory personnel who require updated and complete procedures for use with microelectrode array (MEA) recording technology. Specific cell culture protocols, contamination prevention and control, as well common …
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