Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"L-carnitine"”.
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L-Carnitine Supplementation for Periparturient Dairy Cows
L-Carnitine is required for mitochondrial oxidation of long-chain fatty acids. The objectives of this research were to determine whether L-carnitine supplementation increases hepatic fatty acid oxidation and decreases liver lipid accumulation in dairy cows. In experiment 1, 8 mid-lactation cows …
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Role of Acetyl-L-Carnitine in Hepatic Encephalopathy
… the symptoms of hepatic encephalopathy. Acetyl-L-carnitine, the short-chain ester of carnitine is endogenously produced within mitochondria and peroxisomes and is involved in the transport of acetyl-moieties across the membranes of these organelles. Acetyl-L-carnitine administration has shown the …
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The role of L-carnitine in preventing mitochondrial dysfunction after neonatal hypoxia-ischemia
… leading to metabolic crisis and apoptosis. L-carnitine (LCAR) is an endogenous compound that transports fatty acids across the mitochondrial membrane for metabolism, buffers endogenous acyl-coA pools and improves the health and efficiency of the mitochondria. In light of the mitochondrial …
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The role of L-carnitine in preventing mitochondrial dysfunction after neonatal hypoxia-ischemia
… leading to metabolic crisis and apoptosis. L-carnitine (LCAR) is an endogenous compound that transports fatty acids across the mitochondrial membrane for metabolism, buffers endogenous acyl-coA pools and improves the health and efficiency of the mitochondria. In light of the mitochondrial …
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Investigating the Influence of Fresh and Aged Garlic Extracts on the Biosynthesis of Trimethylamine N-Oxide
… bacteria on dietary precursors including L-carnitine. Dietary supplementation of bioactive garlic phytochemical allicin has recently been suggested to reduce the formation of TMAO precursor molecule trimethylamine (TMA) from L-carnitine through impact on the intestinal bacteria, thereby …
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Enhancing Boar Reproductive Performance for Purposes of Artificial Insemination
… and 2) determine the effects of dietary L-carnitine supplementation on boar libido, semen quality, sperm production, and maintenance of sperm motility during liquid storage. Experiment 1 utilized lean-type, terminal-line boars (National Pig Development, Roanoke Rapids, NC) (n = 40; 177.4 ± …
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Lipid Quantification and Cryopreservation of In Vitro Produced Jersey Cattle Embryos
… been shown to induce lipolysis in IVP embryos. L-carnitine is required for transport of fatty acids from the intermembrane space of the mitochondria into the mitochondrial matrix to support the process of β-oxidation, and enhances ATP production. We hypothesized that the lipid content of in …
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Studies of the expression and characterization of various transport systems at RBE4 cells, an in vitro model of the blood-brain barrier
… 5-HT transporter (SERT) and the organic cation/carnitine transporter OCTN2, was shown at the RBE4 cells. Uptake studies with radiolabeled 5-HT exhibited a saturable, sodium dependent transport at RBE4 cells with a Kt value of about 0.40 µM and a Vmax of about 52 fmol/mg/min. L-carnitine and TEA …
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Quantitative Structure-Activity Relationship Modeling to Predict Drug-Drug Interactions Between Acetaminophen and Ingredients in Energy Drinks
… to acetaminophen, pyridoxine, creatine, L-carnitine, taurine and caffeine did not reveal any significant drug-drug interactions, nor were they predicted by the model.
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The Impact of Dietary Fat and Phosphatidylcholine on Increased Trimethylamine-N-oxide Levels
… such as phosphatidylcholine (PC), choline, and L-carnitine. A high-fat diet is an environmental risk factor that may increase TMAO production. However, it isn’t clear if the high dietary intake of TMA is sufficient to promote increased plasma TMAO or if a high-fat intake is also required. We …
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ACCELERATING WHOLE-CELL BIOCATALYSIS BY ENHANCING OUTER MEMBRANE PERMEABILITY
… O44K74 strain to achieve a higher yield for L-carnitine production. This research and the results outlined in this dissertation demonstrate a valid strategy for addressing permeability issues in whole-cell biocatalysis. The work also highlights a need for accessing substrate permeabilities in …
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Probiotic Supplementation, The Gut Microbiota, and Cardiovascular Health
… humans, the capacity to produce TMAO following L-carnitine or phosphatidylcholine challenges is abolished after receiving broad spectrum antibiotics for a period of one week. However, whether gut modulation over a longer period of time decreases fasting serum endotoxin, fasting plasma TMAO, and …
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Metabolomic Insights into the Pharmacological and Genetic Inhibition of Cyclooxygenase-2
… the pathogenesis of coxib-induced HF. L-Carnitine shuttles activated long-chain fatty acids (FAs) across the inner mitochondrial membrane to the mitochondrial matrix, where they are oxidised by β-oxidation. This is especially important in the heart, which derives the majority of its …
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Effects of nutrition, disease, and body condition score during the transition period on dairy cattle liver gene expression
… of FGF21 under early postpartal ketosis, L-carnitine infusion, a prepartal high energy diet and inflammatory mediators. Ketosis increased the expression and serum level of FGF2; however, a high plasma concentration of carnitine decreased hepatic expression of FGF21. Prepartal high energy …