Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"L-aspartate"”.
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The structure and molecular characterization of of [sic] L-aspartate-[alpha]-decarboxylase from escherichia coli
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1988.
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Structural Studies of Two Enzymes of Pantothenate Biosynthesis in Escherichia Coli
… precursor to coenzyme A, is synthesized from L-aspartate and alpha-ketoisovalerate in a converging four-step process in bacteria. Here, structural studies of two enzymes of pantothenate biosynthesis in Escherichia coli, L-aspartate-alpha-decarboxylase and ketopantoate hydroxymethyltransferase, …
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ΙΔΙΟΤΗΤΕΣ ΤΩΝ ΘΕΣΕΩΝ ΔΕΣΜΕΥΣΗΣ L-ΓΛΟΥΤΑΜΙΚΟΥ L-ΑΣΠΑΡΤΙΚΟΥ ΚΑΙ ΚΑΙΝΙΚΟΥ ΟΞΕΟΣ ΕΓΚΕΦΑΛΟΥ ΠΤΗΝΩΝ. "ΣΥΜΒΟΛΗ ΣΤΗΝ ΑΠΟΜΟΝΩΣΗ ΚΑΙ ΧΑΡΑΚΤΗΡΙΣΜΟ ΤΩΝ ΘΕΣΕΩΝ ΔΕΣΜΕΥΣΗΣ L-ΓΛΟΥΤΑΜΙΚΟΥ ΟΞΕΟΣ"
… AND REGIONAL ONTOGENY OF L-GLUTAMATE, L-ASPARTATE AND KAINATE BINDING SITES HAVE BEEN STUDIED IN MEMBRANE PREPARATIONS OF CHICK BRAIN. ONE BINDING COMPONENT WAS FOUND FOR L-[3H]GLUTAMATE AND L-[3H] ASPARTATE WITH A KD VALUE OF 176 NM AND 204 RESPECTIVELY. FOR KAINIC ACID TWO BINDING …
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The synthesis and pharmacology of some novel excitatory amino acid analogues
Certain amino acids, notably L-glutamate and L-aspartate, are believed to fulfil a role as excitatory neurotransmitters in the mammalian Central Nervous System (CNS). Investigation has revealed the presence of three, and possibly a fourth, type of receptor for such neurotransmitters. These …
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SYNTHESIS OF N<sub>B</sub>-ARYL-ASPARTAMIDES, N<sub>a</sub>-ARYLAMIDE-ASPARTATES, AND HYDROXY-L-PROLINE DERIVATIVES AS INHIBITORS OF AMINO ACID TRANSPORT FOR EVALUATING THE GLUTAMINE / GLUTAMATE CYCLE
… of amino acid analogs, based off of an L-aspartate or L-proline scaffold, to be evaluated as inhibitors of the amino acid transporters ASCT (subtypes 1 & 2) and the excitatory amino acid transporters EAATs (subtypes 1-3), both involved in the glutamate / glutamine cycle. Furthermore, we …
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SYNTHESIS OF N<sub>B</sub>-ARYL-ASPARTAMIDES, N<sub>a</sub>-ARYLAMIDE-ASPARTATES, AND HYDROXY-L-PROLINE DERIVATIVES AS INHIBITORS OF AMINO ACID TRANSPORT FOR EVALUATING THE GLUTAMINE / GLUTAMATE CYCLE
… of amino acid analogs, based off of an L-aspartate or L-proline scaffold, to be evaluated as inhibitors of the amino acid transporters ASCT (subtypes 1 & 2) and the excitatory amino acid transporters EAATs (subtypes 1-3), both involved in the glutamate / glutamine cycle. Furthermore, we …
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Peptide-Functionalized Layer-by-Layer Nanoparticles Demonstrate Improved Blood Brain Barrier Permeability for Glioblastoma Treatment
… to a conclusion that the combination of a poly-L-aspartate outer layer and Angiopep-2 leads to significant improvement in nanoparticle uptake in the brain. Future work will include in vivo experiments with peptide-functionalized LbL nanoparticles with a hyaluronic acid (HA) outer layer, as HA …
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Gene Delivery to the Blood-Brain Barrier for Ischemic Stroke Therapy
… (poly (ethylene glycol)<sub>5k</sub>-poly (L-aspartate-diethylenetriamine)<sub>48</sub> (PEG-DET) / Pluronic P84 (P84) and exosomes (EXOs) / microvesicles (MVs)) to deliver brain-derived neurotrophic factor (BDNF) plasmid DNA (pDNA), a functional gene encoding a neurotrophin. In the first …
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Genome scale metabolic modelling to identify metabolic responses of resistant bacteria to antibiotic challenges
… anaerobic growth conditions, utilisation of L-aspartate as a substrate and fumarate as a terminal electron acceptor was also identified. A novel method comparing in silico knockouts in models and essential genes determined by transposon mutagenesis was developed as a part of this study. …
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The structure and function of Gene's organ and its associated glands in ticks
… is presented implicating L-glutamate and L-aspartate as excitatory transmitters at the neuromuscular junctions.
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Flavin-dependent Enzymes in Natural Product Biosynthesis
… a highly coupled and specific reaction with L-aspartate and NADPH to produce nitrosuccinate. Both AsFMO and FzmM followed a kinetic mechanism representative of class B flavin-dependent monooxygenases with a rapid pro-R stereospecific reduction and the formation of a C(4a)-hydroperoxyflavin …
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Mechanisms of Flavin-Dependent Monooxygenases Involved in Natural Product Chemistry
… nitrogen oxidation reactions to convert L-aspartate to nitrosuccinate en route to biosynthesis of cremeomycin. For each enzyme, the steady-state kinetics have been determined using an oxygen consumption assay and the rapid-reaction kinetics were measured using anaerobic time-resolved …
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An Account of Chemical and Mechanical Regulation of TRPC6 Channels in Podocytes
… (AT1R), insulin receptors, and N-methyl-D-aspartate receptors (NMDAR) on TRPC6 activity are studied here. In acutely isolated rat glomeruli, angiotensin causes an upregulation of TRPC6 activity, and this is mediated by the Gαq /PLC pathway. This angiotensin-evoked upregulation is partially …
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Μελέτη των θέσεων δέσμευσης του L-γλουταμικού οξέος σε φυσιολογική και ατροφική ανθρώπινη παρεγκεφαλίδα: Συμβολή στη μελέτη της ελαιογεφυρο-παρεγκεφαλιδικής ατροφίας
… binding sites about 4/1. L-glutamate, L-aspartate, quisqualate, L-homocysteic and ibotenic acid were potent inhibitors of L-[³H] glutamate binding, whereas D,L-APB, kainic acid and NMDA were weak inhibitors. L-[³H] glutamate binding showed a significant degree of stereoselectivity toward …
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Elaboration of 4′-Phosphopantetheine Adenylyltransferase inhibitors and Benzoxaboroles as antimalarial agents
… pyrimidine biosynthesis precursors N-carbamoyl-L-aspartate (N-Carb-Asp) and dihydroorotate (DHO) and a marked decrease in a number of peptides. 28/MM2-145 was found to cause an increase in pyrimidine biosynthesis precursors. The increase in pyrimidine biosynthesis precursors implicates pathways …
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The UP AMIGOS project: Testing the predictive validity of the 2007 Pediatric Expert Committee Recommendations in Latinos
Background. Mexicans are disproportionately affected by cardiovascular disease and there is mounting evidence that Mexicans may be genetically prone to the development of cardiovascular disease (CVD) risk factors. Objective. There were three aims of study. The first aim was to identify the …