Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"L-alanine"”.
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A toxicological analysis of the cyanotoxin β-methylamino-L-alanine at multiple neural levels and identification of novel modes of activity
The cyanotoxin β-methylamino-L-alanine (BMAA) has long been associated with the elevated incidence of amyotrophic lateral sclerosis/Parkinsonism dementia complex (ALS/PDC). BMAA has been shown to be produced across the cyanobacterial order and its detection has been reported in a variety of aquatic …
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Nutrient Controls Over Cyanobacterial Synthesis of the Neurotoxin β-N-Methylamino-L-Alanine (BMAA) and Its Potential Accumulation in the Blue Crab (<i>Callinectes Sapidus</i>)
… is the non-protein amino acid β-N-methylamino-L-alanine (BMAA), which has epidemiological linkages to the development of several human neurological diseases. Three cyanobacterial species thought to produce BMAA —<em>Microcystis aeruginosa</em>, <em>Synechococcus bacillaris</em>, and <em>Nostoc …
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Chemical and Enzymatic Synthesis of Dehydropeptides and Their Fluoro Analogs
Fluorine-substituted dehydroalanine can lead to irreversible linkages of nucleophile to dehydroalanines by an addition elimination mechanism and can be applied to the design of enzyme inhibitors and active site affinity labels. Fluorodehydroalanine has been synthesized from serine in 7 steps with a …
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Non-electrolyte transport in brush border membrane vesicles from bovine small intestine
… D-galactose, and D-xylose. Transport of L-alanine was sodium stimulated and mediated by at least two systems. Apparent affinities for L-alanine transport were .039, and .943 mM. Maximum velocities were 29.2, and 53.4 pmoles/mg protein/sec, for the two systems. Transport of L-proline, …
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Preserving spore dormancy
… spore development. In Bacillus subtilis, L-alanine and L-valine create a metabolic conflict: they are required for biosynthesis during sporulation but also act as strong germinants. Wild-type populations resolve this by collectively depleting extracellular alanine and valine before spores …
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Novel ferrocenyl benzoyl peptide esters as anti-cancer agents and ferrocenoyl self assembled monolayers as anion sensors
… to be N-{meta-(ferrocenyl)- benzoyl}-glycine-L-alanine ethyl ester with an IC50 value of 4.0 μM while N-{ortho-(ferrocenyl)-benzoyl}-glycine-L-alanine ethyl ester induced a block in the G2/M phase of the cell cycle. {N-ortho-(ferrocenyl)-benzoyl}2-L-cystine dimethyl ester displayed a linear …
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Analysis of the Roles of the cwlD Operon Products during Sporulation in Bacillus subtilis
… has sequence similarities to N-acetyl muramoyl-L-alanine amidases, a class of enzymes known to cleave the bond between the peptide side chain and the N-acetyl muramic acid residue in cortex peptidoglycan formation during sporulation. A major difference between vegetative peptidoglycan and spore …
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Synthesis and mass spectrometry studies of oligopeptides
… of model N- and C-terminal cysteine polyalanine peptides in which one L-alanine was substituted by a D-alanine viz. CAA<sup>D</sup>A and AA<sup>D</sup>AC, were measured by the extended Cooks kinetic method. Gas-phase acidities of CAA<sup>D</sup>A and AA<sup>D</sup>AC were measured to be …
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Dynamic charge densities of amino acids and proteins
… data sets of α-glycine, D,L-serine, L-alanine and L-alanyl-L-tyrosyl-L-alanine (Ala-Tyr-Ala) as well as the protein Crambin (T = 100 K). By using a multi-temperature data set of D,L-serine, the effect of temperature on electron densities have been analyzed. Density values near atomic …
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Atomistic simulation of self-organization in semiconducting polymers and polypeptides with molecular dynamics and Monte Carlo methodologies
… for homo-polypeptides based on the L-alanine amino acid residue. The new methodology was capable of predicting the secondary structure of homo-polypeptides consisting of a few decades of residues, characterized by the formation of a significant population of α-helix secondary structure …
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The inhibition of germination and growth of Clostridium botulinum 62A by BHA, BHT, TBHQ and 8-Hydroxyquinoline
… using a defined liquid medium containing L-alanine, L-lactic acid and NaHC0₃. Cell growth was monitored by optical density (600 nm) increase and germination was monitored either by optical density (600 nm) decrease or by increase in percent phase dark spores viewed under phase contrast …
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The proton-coupled oligopeptide transporters PEPT2, PHT1 and PHT2 mediate the uptake of carnosine in glioblastoma cells
… LN405, the competitive inhibitors β-alanyl-L-alanine (inhibits all transporters) and L-histidine (inhibitor of PHT1/2) both inhibited the uptake of carnosine. SiRNA-mediated knockdown of PHT1 and PHT2 revealed a significantly reduced uptake of carnosine. Interestingly, despite its low …
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Lipid accumulation and utilization during microcycle growth of Aspergillus niger.
… the carbon substrates glucose, L-glutamate and L-alanine, they were provided in a radiolabelled form and the fate of the label followed at intervals throughout the cycle. The majority of the material was used in the production of insoluble cellular material, with smaller amounts incorporated into …
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The synthesis of fungicidal aminophosphonic acid derivatives
… moderate to good antifungal activity, with the L-alanine di- and tripeptides of l-aminopropanephosphonic acid having superior activity to the commercial fungicide imazalil when tested against D. teres and D. avenae. The proton, carbon-13 and phosphorus-31 nmr spectroscopy of the compounds prepared …
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Formation of 4(5)-methylimidazole in processed meat and in glucose amino acid model system
… or 0.15 M and equal volume with [subscript]L-Alanine (Ala), [subscript]L-Arginine (Arg), Glycine (Gly), [subscript]L-Lysine (Lys), and [subscript]L-Serine (Ser); and the mixtures were heat treated at 60, 120, and 160°C for 1 h. Among all tested amino acids, Glu-Arg produced the highest level …
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Synthesis of the small peptide analogues of cyclin dependent kinase (CDK4) for cancer treatment
… most potent for anticancer activity. Therefore, alanine scanning compounds of hexapeptide 71 were synthesized by replacing each amino acid residue with L-alanine to investigate which amino acid residue had shown anticancer activity. Solid phase method was also optimized to synthesized peptide 1 …
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Development of Epipolythiodiketopiperazine syntheses and the total synthesis of diketopiperazine alkaloids
… began from the simple starting materials L-alanine and Ltryptophan. Transformations central to our route include a highly regioselective Friedel- Crafts indolization that can be performed on multi-gram scale, as well as a highly diastereoselective oxidation and thiolation. Moreover, this …
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SMN DEFICIENCY INDUCES NEUROACTIVE AMINOACIDS DYSMETABOLISM: BRIDGING INSIGHTS FROM PRECLINICAL MODELS TO CLINICAL EVIDENCE IN SMA PATIENTS
… widespread depletion of L-arginine and L-alanine across skeletal muscle, liver, kidney, and serum, alongside elevated glutamine/glutamate ratios, a systemic signature conserved in Drosophila SMA models. These metabolic changes were accompanied by stereospecific imbalances in D/L amino …
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