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Showing 1 to 20 of 35 for “"L-Proline"”.
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The Effect of L-Proline on Two Recombinant AMPA Glutamate Receptors
<p>L-proline is a non-essential amino acid and one of the major amino acid constituents of extracellular fluid. Specific mutations in genes that control proline metabolism lead to hyperprolinemia which is characterized by an increase in the level of blood and cerebrospinal fluid concentration of …
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SYNTHESIS OF N<sub>B</sub>-ARYL-ASPARTAMIDES, N<sub>a</sub>-ARYLAMIDE-ASPARTATES, AND HYDROXY-L-PROLINE DERIVATIVES AS INHIBITORS OF AMINO ACID TRANSPORT FOR EVALUATING THE GLUTAMINE / GLUTAMATE CYCLE
… acid analogs, based off of an L-aspartate or L-proline scaffold, to be evaluated as inhibitors of the amino acid transporters ASCT (subtypes 1 & 2) and the excitatory amino acid transporters EAATs (subtypes 1-3), both involved in the glutamate / glutamine cycle. Furthermore, we have identified a …
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SYNTHESIS OF N<sub>B</sub>-ARYL-ASPARTAMIDES, N<sub>a</sub>-ARYLAMIDE-ASPARTATES, AND HYDROXY-L-PROLINE DERIVATIVES AS INHIBITORS OF AMINO ACID TRANSPORT FOR EVALUATING THE GLUTAMINE / GLUTAMATE CYCLE
… acid analogs, based off of an L-aspartate or L-proline scaffold, to be evaluated as inhibitors of the amino acid transporters ASCT (subtypes 1 & 2) and the excitatory amino acid transporters EAATs (subtypes 1-3), both involved in the glutamate / glutamine cycle. Furthermore, we have identified a …
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Chemoreception of sugars and amino acids in female fourth and sixth instars of the spruce budworm, Choristoneura fumiferana (Clem.)
… to be sensitive to all l-amino acids except l-proline. The latter was detected by a neuron on the medial sensillum. Sixth instar larvae were significantly more responsive to the l-amino acids than the younger instars. However, there was no correlation between the neurophysiological input …
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Interaction of peptides, peptidomimetics and other drug candidates with the DI/tripeptide transport system in intestinal epithelial cells, using the in vitro caco-2 cell culture system
… cell monolayers and the dipeptide, glycyl-[3H]L-proline, as a probe compound. Glycyl-[3H]L-proline uptake was via the di-/tripeptide transport system (DTS) and, exhibited concentration-, pH- and temperature-dependency. Dipeptides inhibited uptake of the probe, and the design of the system allowed …
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Non-electrolyte transport in brush border membrane vesicles from bovine small intestine
… protein/sec, for the two systems. Transport of L-proline, L-lysine, L-methionine, and L-phenylalanine were sodium stimulated. Data indicated sodium independent transport accounted for more influx of L-lysine, L-methionine, and L-phenylalanine than sodium dependent transport. Sodium dependent and …
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Functional studies of selected actin binding proteins by point mutations and GFP fusions
… profilin is no longer able to bind to poly-(L)-proline concomitant with a slight reduction in actin-binding, whereas the K114E profilin shows profound decrease in its ability to interact with actin but its affinity for poly-(L)-proline remained unaltered. The in vivo properties of the …
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Diastereoselective Lithiation-Substitution of N-Silyl-Protected-(S)-Tetrahydro-1H-pyrrolo[1,2-c]imidazole-3(2H)-ones and Applications of Their Derivatives
… a method involving the preparation of an L-proline-derived imidazolone protected with an N-triethylsilyl group that undergoes diastereoselective lithiation followed by electrophile quench to give C5-substituted products with syn stereochemistry. The N-silylated derivatives may be more easily …
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Diastereoselective Lithiation-Substitution of N-Silyl-Protected-(S)-Tetrahydro-1H-pyrrolo[1,2-c]imidazole-3(2H)-ones and Applications of Their Derivatives
… a method involving the preparation of an L-proline-derived imidazolone protected with an N-triethylsilyl group that undergoes diastereoselective lithiation followed by electrophile quench to give C5-substituted products with syn stereochemistry. The N-silylated derivatives may be more easily …
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Profilin II : novel functions in membrane trafficking
… remodelling. Besides actin, it binds to poly-L-proline and phosphatidylinositol phoshates. Mice have three profilin genes, with profilin I being ubiquitously expressed, profilin II a brain specific isoform and profilin III expressed in kidney and testis. Via its poly-L-proline binding site …
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Nutrition in relation to coremia and spore production in Penicillium clavigerum
… glucose, mineral salts; and the amino acid L-proline was developed for the propagation of Penicillium clavigerum. Certain modifications of this medium produce dramatic differences in colonial morphology. Coremia are produced only if certain dipeptides are added to the medium. The dipeptides …
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Intestinal absorption barriers as modelled by p-glycoprotein and cytochrome p450 a34 in caco2 cells
… I) cells are less effective in translocating L-proline and glycyl-L-proline across the cell mono layers.
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The synthesis and evaluation of halo and protio enol lactone Pro-Val pseudodipeptides as potential inhibitors of human leukocyte elastase
… 19a and 19b, prepared in six steps from Boc-(L)-proline.
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Synthesis and catalytic testing of a proline functionalized amphiphilic block copolymer
… a hydrophobic O-methacryloyl-trans-4- hydroxy-L-proline and methyl methacrylate end and a hydrophilic acrylic acid end was characterized. The polymer was tested as an asymmetric catalyst for an aldol reaction in aqueous conditions. The polymer was able to successfully stereoselectively catalyze …
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Advancements in green chemistry approaches to chemical synthesis
… E derived TPGS-750-M by Lipshutz's group and L-proline based PS- 750-M from Handa's group, polyethylene glycol moiety as a hydrophilic part may not be biodegradable. Therefore, a second-generation PS-750-M (2nd Gen-PS) is developed as an alternative of polyethylene glycol (PEG)-based surfactant. …
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Sintesi di molecole organiche enantiomericamente arricchite con l'uso della catalisi organica
… acids derivatives as catalysts, for example L-proline, L-pyrrolidine tetrazole and so on. This is important because is necessary to found news synthetic methods to produce pyridines nucleus that are very important building block for drugs. Following it is illustrated a preliminary result of a …
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Hemiaminals : a new chemotype for organocatalysis
… an azodicarboxylate as the electrophile using L -proline enamine catalysis in 2002. Following borohydride reduction, the α-hydrazino alcohol was obtained in high yield (93-99%) and enantioselectivity (86-97%). Application of the enantioselective α-amination reaction to an acetal as a masked …
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Synthesis and biological evaluation of aeruginosin based compounds and self-assembly of glucosamine based compounds
… 298-A, in which the Choi will be replaced with L-proline and oxygenated Choi analogs, and the Argol is replaced with various other functionalities. The preparation of oxygenated Choi analogs starting from glucose using a new method has been discussed.</p> <p>In the second part of my dissertation, …
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Use of organocatalysts in stereoselective organic synthesis
… aryl aldehydes catalyzed by N-phenylsulfonyl (S)-proline and via asymmetric nitro-Michael reaction of 3-substituted cyclobutanones and several nitrostyrenes catalyzed by thiourea derivatives. In the first case the relative aldol products were obtained with an unprecedented control of all three …
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Structures of the Didemnins (Antiviral, Antitumor, Compounds)
… (Thr), 3S,4R-statine (Sta), L-leucine (Leu), L-proline (Pro), and N,O-dimethyl-L-tyrosine (Me(,2)Tyr), and a 2R,4R-hydroxyisovalerylpropionyl (Hip) group. Didemnins B-E differ from didemnin A by acylation of the methylamino group of MeLeu with the substitutents shown. Didemnin B is the most …
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