Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"L-Homoserine"”.
-
N-(3-Oxododecanoyl)-L-Homoserine Lactone in the Breast Tumor Microenvironment
The tumor microenvironment is a well-recognized contributor to cancer progression in solid tumors. Cancer cell interactions with abnormal extracellular matrix, tumor associated immune and stromal cells, and aberrant fluid flow all contribute to cancer progression. Breast tumors are often …
-
Dietary guanidino acetic acid spares arginine and dietary l-homoserine spares threonine in the chick
… methyllated by S-adenosylmethione to creatine. L-Homoserine (HS) has been identified as an intermediate compound in the metabolism of Thr, Met, and Asp. Bacteria, plants and yeast can synthesize Thr and Met from HS, but this has not been shown in higher organisms. Several bioassays were carried …
-
Synthesis and biological research of the pseudomonas aeruginosa signaling compounds PQS and N-3-oxo-dodecanoyl-L-homoserine lactone
… aeruginosa signaling molecules 3-oxo-C12-homoserine lactone and Pseudomonas quinolone signal were synthesized so that the mammalian cellular responses to their presence via an infection could be studied. It was hypothesized that differing combinations of the signaling molecules would …
-
Mutant analysis of luminescence and autoinduction in a marine bacterium
… chemically purified and shown to be Noctanoyi- L-homoserine lactone. The genetic locus encoding the AI-2 synthase was cloned and designated ain (autoinducer). Manipulation of ain and AI-2 in V. jischeri demonstrated that the function of AI-2 appears to be to inhibit rather than to promote …
-
Enhancing energy recovery from industrial wastewater using microbial fuel cells
… The quorum sensing molecule N (-3-oxodecanoyl)-L-homoserine lactone of different concentrations was for the first time exogenously added to MFCs and its effect on biofilm formation and power production determined. The results were compared with control experiments without N …
-
Integrated functional anlaysis of quorum-sensing in the rice pathogenic bacterium Burkholderia glumae
… by the core genes, tofI and tofR. N-octanoyl-L-homoserine lactone, the primary QS signal molecule of B. glumae, is synthesized by tofI and binds to the cognate receptor tofR at the quorum point. However, tofI and tofR null mutants produce toxoflavin in certain growth conditions, indicating the …
-
N-acylhomoserine lactone regulation of adhesion and biofilm differentiation in Serratia marcescens MG1
… a diffusible signal identified as N-butanoyl-L-homoserine lactone (C4-HSL). The aim of this study was to determine the role of C4-HSL in surface colonisation (adhesion and biofilm formation). In this thesis, the development of a novel biofilm in S. marcescens MG1 is described. The biofilm …
-
Genetic and Biochemical Characterization of the Mechanisms Concerning the TraR/AAI/TraM Mediated Quorum Sensing That Regulates Ti Plasmid Conjugation
… is achieved by producing and sensing an acyl-homoserine lactone molecule. In Agrobacterium tumefaciens , regulation of Ti plasmids conjugation is controlled in part by a quorum-sensing system consisting of four elements; the transcription activator TraR, the intercellular signal …
-
Analysis of the Regulons Controlled by Transcriptional Regulators LuxR and LitR in Vibrio fischeri
… was dependent on LuxR and 3-oxo-hexanoyl-L-homoserine lactone (3-oxo-C6-HSL). A lacZ reporter was used to show that the promoters for qsrP, acfA, and ribB were directly activated via LuxR-3-oxo-C6-HSL in recombinant Escherichia coli. The sites of transcription initiation were established via …
-
Novel small molecules for modulation of bacterial signaling pathways
… QS signaling molecules, such as N-acylated L-homoserine lactones (AHLs), indoles, N-acetyl glucosamine and other heterocyclic systems derived from halogenated furanones (Fimbrolides). Indole and glucosamine-based amides and oxo-amides were synthesized as non-native AHL mimics by applying EDC, …