Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"L-Glutamate"”.
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Behavioral and Neurochemical Effects of Neonatal Administration of Monosodium L-Glutamate in the Mouse.
Hetherington and Ranson (1940) demonstrated that small bilateral lesions in the ventromedial nucleus of the hypothalamus. (VMH) produce overeating and obesity. Their observation served to focus attention on the central nervous system (CNS) as the site of systems that regulate food intake.
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Μελέτη των θέσεων δέσμευσης του L-γλουταμικού οξέος σε φυσιολογική και ατροφική ανθρώπινη παρεγκεφαλίδα: Συμβολή στη μελέτη της ελαιογεφυρο-παρεγκεφαλιδικής ατροφίας
… of Cl⁻ dependent and/ CI⁻independent L-glutamate binding sites were studied in membrane preparations and sections of human cerebellum. Furthermore L-glutamate binding have been solubilized from the same membrane preparations using different detergents, as CHAPS, Zwittergent 3-12 and …
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Study of the etiology of neurolathyrism, a human neurodegenerative disease with nutritional causes
… effect of L-β-ODAP was studied as compared to L-glutamate on the permeability of the blood-brain barrier (BBB), on the survival and functioning of neuronal and glial cells, and free amino acids were analyzed in urine of neurolathyrism patients. An in vitro model for the BBB, consisting of brain …
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ΙΔΙΟΤΗΤΕΣ ΤΩΝ ΘΕΣΕΩΝ ΔΕΣΜΕΥΣΗΣ L-ΓΛΟΥΤΑΜΙΚΟΥ L-ΑΣΠΑΡΤΙΚΟΥ ΚΑΙ ΚΑΙΝΙΚΟΥ ΟΞΕΟΣ ΕΓΚΕΦΑΛΟΥ ΠΤΗΝΩΝ. "ΣΥΜΒΟΛΗ ΣΤΗΝ ΑΠΟΜΟΝΩΣΗ ΚΑΙ ΧΑΡΑΚΤΗΡΙΣΜΟ ΤΩΝ ΘΕΣΕΩΝ ΔΕΣΜΕΥΣΗΣ L-ΓΛΟΥΤΑΜΙΚΟΥ ΟΞΕΟΣ"
… PROPERTIES AND REGIONAL ONTOGENY OF L-GLUTAMATE, L-ASPARTATE AND KAINATE BINDING SITES HAVE BEEN STUDIED IN MEMBRANE PREPARATIONS OF CHICK BRAIN. ONE BINDING COMPONENT WAS FOUND FOR L-[3H]GLUTAMATE AND L-[3H] ASPARTATE WITH A KD VALUE OF 176 NM AND 204 RESPECTIVELY. FOR KAINIC ACID TWO …
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Influence of Prion Protein Expression on Function of Excitatory Amino Acid Transporters in Mouse Primary Astrocytes
… suggestive that PrP may function in the glutamatergic synapse. Here we show that transport of D-aspartate, a non-metabolized L-glutamate analog, through excitatory amino acid transporters (EAATs) was faster in astrocytes from PrP knockout (PrP KO) mice than in astrocytes from C57BL/10 SnJ …
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Influence of Prion Protein Expression on Function of Excitatory Amino Acid Transporters in Mouse Primary Astrocytes
… suggestive that PrP may function in the glutamatergic synapse. Here we show that transport of D-aspartate, a non-metabolized L-glutamate analog, through excitatory amino acid transporters (EAATs) was faster in astrocytes from PrP knockout (PrP KO) mice than in astrocytes from C57BL/10 SnJ …
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Exogenous γ-Glutamyl Cycle Compound Supplementation to In Vitro Maturation Medium and the Effects on Subsequent In Vitro Fertilization and Culture Parameters of Porcine Oocytes and Their Impact on Embryo Viability
… 2.5 mM glycine, 5.0 mM glycine; 1.0 mM L-glutamate, 2.5 mM L-glutamate, 5.0 mM L-glutamate; and 3.3 mM L-α-aminobutyrate, 25 μM β-mercaptoethanol, 3.3 mM cysteine and 25 μM β-mercaptoethanol, or 3.3 mM L-α-aminobutyrate and 25 μM β-mercaptoethanol. After IVM (44 h), concentrations of …
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Folate Metabolism in the Guinea Pig
… (major product) and p-acetamidobenzoyl- L-glutamate (minor product) were found in the urine. No radioactive folate was excreted except at very high doses when trace amounts of folic acid appeared, or after pre-treatment of the guinea pigs with antibiotics or methotrexate. Up to 20% of an …
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Synthetic polypeptide-based hydrogel systems for biomaterials
… a new random copolymer, poly(y-propargyl-L-glutamate-co-[gamma]-allyl-L-glutamate) (PPALG) is presented that exploits both the azide-alkyne and thiol-ene click reactions to allow orthogonal side chain modification to increase chemical complexity and ultimately allow a library of "designer" …
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BIOISOSTERES OF AMPA: CONFORMATIONAL ANALYSIS AND STRUCTURE ACTIVITY RELATIONSHIP
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). Concentrations of L-glutamate in the CNS are regulated by a family of excitatory amino acid transporters (EAATs) that rapidly sequester and concentrate glutamate in glia and neurons, and thereby …
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BIOISOSTERES OF AMPA: CONFORMATIONAL ANALYSIS AND STRUCTURE ACTIVITY RELATIONSHIP
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). Concentrations of L-glutamate in the CNS are regulated by a family of excitatory amino acid transporters (EAATs) that rapidly sequester and concentrate glutamate in glia and neurons, and thereby …
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The synthesis and pharmacology of some novel excitatory amino acid analogues
Certain amino acids, notably L-glutamate and L-aspartate, are believed to fulfil a role as excitatory neurotransmitters in the mammalian Central Nervous System (CNS). Investigation has revealed the presence of three, and possibly a fourth, type of receptor for such neurotransmitters. These …
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Glycogen metabolism in Corynebacterium glutamicum ATCC 13032
… in the synthesis of amino acids, such as L-glutamate and Llysine. The central metabolic pathways of this organism has been an area of much research by many groups. Linked to glycolysis is the synthesis of glycogen, previously considered a storage molecule of excess glucose. No information …
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Lipid accumulation and utilization during microcycle growth of Aspergillus niger.
… of each of the carbon substrates glucose, L-glutamate and L-alanine, they were provided in a radiolabelled form and the fate of the label followed at intervals throughout the cycle. The majority of the material was used in the production of insoluble cellular material, with smaller amounts …
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Development and study of synthetic polypeptides for biomaterial applications
… synthetic polypeptide poly(ypropargyl L-glutamate) (PPLG) to form a self-assembly amphiphilic system is discussed, as is the formation of potentially amphiphilic block copolymers with PPLG. The synthesis of a hydrolytically stable synthetic polypeptide with click functionality is also …
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L-arginine overproduction in Corynebacterium glutamicum ATCC 13032
… a variety of amino acids, including L-lysine, L-glutamate and L-threonine. With the exception of Larginine, the biosynthesis and regulation of most of these compounds in this bacterium are relatively well characterised in the literature. The research presented here focuses on improving our …
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
L-Glutamate is the major excitatory neurotransmitter in the mammalian CNS that can mechanistically contribute to either neuronal signaling or neuronal pathology. Consequently, its concentration in the CNS must be carefully regulated, a critical need that is met by the excitatory amino acid …
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Elucidation of the Specificity of Neuroactive Steroids and Related Compounds at the at the Vesicular Glutamate Transporter
As the primary excitatory amino acid, glutamate is essential to proper functioning of the mammalian CNS. Proper regulation of the synaptic release of glutamate, potentially regulated by synaptic vesicle content, is one of many critical aspects to normal excitatory functioning. In particular, the …
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
L-Glutamate is the major excitatory neurotransmitter in the mammalian CNS that can mechanistically contribute to either neuronal signaling or neuronal pathology. Consequently, its concentration in the CNS must be carefully regulated, a critical need that is met by the excitatory amino acid …
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Elucidation of the Specificity of Neuroactive Steroids and Related Compounds at the at the Vesicular Glutamate Transporter
As the primary excitatory amino acid, glutamate is essential to proper functioning of the mammalian CNS. Proper regulation of the synaptic release of glutamate, potentially regulated by synaptic vesicle content, is one of many critical aspects to normal excitatory functioning. In particular, the …
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