Global ETD Search
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Showing 1 to 1 of 1 for “"L-2-hydroxyglutarate"”.
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The role of ABHD11 in the regulation of the hypoxia inducible transcription factors
… the accumulation of 2-OG and formation of L-2-hydroxyglutarate, an inhibitor of PHDs. Patients with hereditary mutations in the OGDHc develop tumour syndromes, typical of HIF activation. However, how the OGDHc is regulated is not known. In this thesis, I optimise CRISPR/Cas9 forward genetic …