Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"L cells"”.
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The Hormonal Regulation of Growth of Suspension Cultures of Acer pseudoulatanus L. cells
… in an auxin-dependent line (OS) of sycamore cells have suggested that endogenous IAA may be a major regulatory factor during a large part of a culture passage. Further experiments with two auxin-prototrophic cell lines (HK and EHM) have revealed that auxin-prototrophy cannot be explained …
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The Diversion of Macromolecular Synthesis in L-Cells Towards Ends Dictated by Mengovirus
<p>The last few years have seen the beginnings of biochemical and physiological studies on animal virus multiplication. Work of this kind with bacterial viruses had begun in the early 1950's and provided much information before research on animal viruses was initiated. The delay in the study of …
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Exploring glucagon-like peptide 1-secreting L-cells as signal transducers in the microbiota-gut-brain signalling pathways
… for their numerous health benefits. L-cells are located at the intersection of the gut barrier, and the host endocrine and neural systems. As such, these cells may act as signal transducing cells by releasing GLP-1 basolaterally following stimulation by nutritional, microbial, or liver …
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Comparative analysis of two attachment variants of butyrivibrio fibrisolvens.
… were examined. Compared to the non-adhering L cells, the adhering S cells were shinier, spherical, more intensely pigmented (yellow), more firmly attached to the agar surface and could only be removed with scraping. After longer incubation, the cells were released from the agar but the colonies …
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Characterisation of L-cell secretory mechanisms and colonic enteroendocrine cell subpopulations
Enteroendocrine cells (EECs) are chemosensitive cells of the gastrointestinal epithelium that exert a wide range of physiological effects via production and secretion of hormones in response to ingested nutrients, bacterial metabolites and systemic signals. Glucagon-like peptide-1 (GLP-1) is one …
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Identification of genipin as a potential treatment for type 2 diabetes
… insulin resistance, and the dysfunction of β-cells. While there are several therapies for T2D, there is no effective treatment that can reverse the functional decline of pancreatic β cells in T2D patients. Glucagon-like peptide-1 (GLP-1) is a peptide hormone secreted by human intestinal L …
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Identification of a Dual-Action Small Molecule with Potent Anti-diabetic and Anti-obesity Activity
… incretin that is secreted from enteroendocrine L-cells in response to food ingestion, plays a vital role in maintaining glycemic homeostasis via potentiating glucose stimulated insulin secretion (GSIS) and promoting pancreatic β-cell proliferation and survival. Therefore, targeting L-cells to …
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G-Protein Coupled Receptors Modulating Incretin Hormone Secretion
… glucagon-like peptide-1 (GLP-1), secreted from K-cells and L-cells respectively, augment insulin secretion. In addition, GIP facilitates triglyceride storage and GLP-1 has anorexic effects. Incretins are released from the gastrointestinal tract in response to food ingestion. Great interest exists …
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Mechanisms underlying monosaccharide stimulated incretin hormone secretion from the intestine
… Gut hormones are produced by enteroendocrine cells (EECs) of the intestinal epithelium and are released in response to a variety of intestinal signals, with diverse roles in the control of metabolism. The gut hormones GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), known as …
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β-arrestin interacting domains on the type II gonadotropin-releasing hormone (GnRH) receptor
Over-expression of β-arrestin 1 in COS-l cells revealed that the mammalian type GnRH receptor can internalise in a β-arrestin dependent manner whereas the internalisation of the mammalian type I GnRH receptor is β-arrestin independent. investigate which domains on the mammalian type II GnRH …
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Circadian Secretion of Glucagon-like Peptide-1
… spectrometry analysis of murine (m) GLUTag L cells identified the SNARE-accessory protein STXBP-1 to be increased at peak GLP-1 secretion, potentially as a result of time-dependent binding of BMAL1 to its promoter region. Metabolic testing in normal and WD-fed mice throughout the 24-hour day …
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Contactless Dielectrophoresis towards Drug Screening and Microdevice Development for Cell Sorting
… phenotype of late-stage ovarian cancer cells to a profile similar to that of slow-growing early-stage ovarian epithelial cells after treatment with a non-toxic bioactive metabolite, sphingosine. Current chemotherapeutics are highly toxic to patients and can cause severe adverse side …
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Immunoisolation Approaches for Islet Transplantation
… ineffective at the subcutaneous site. Helper cells can be used to improve islet transplantation by secreting beneficial factors. L cells produce glucagon-like peptide-1 which is known to have several positive effects on islets. Co-encapsulation of islets with L cells increased islet insulin …
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Harnessing transcriptomic data to better understand gene regulatory mechanisms of neurodevelopmental disorders
… study NMD roles of the UPF3 paralogs in mouse L-cells by analysing Upf3a- and Upf3b-deficient transcriptomes. These analyses reveal that the loss of Upf3a resembles the loss of UPF3B-NMD and support a mild NMD activator role of UPF3A in mouse L-cells. I then expand my investigations into the role …
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Characterisation of human enteroendocrine cells in organoid models
Gut hormones secreted by enteroendocrine cells (EECs) coordinate the postprandial response to a meal by regulating digestion, absorption, circulating nutrient availability and satiety. EECs are specialised endocrine cells scattered throughout the gastrointestinal epithelium that release hormones in …
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Role of ryanodine receptors in neuronal calcium signalling and growth control
… activation of Ca<sup>2+</sup> influx in these cells. The Ca<sup>2+</sup> influx signal due to these agonists can be inhibited by SOC blockers such as La<sup>3+</sup>, Zn<sup>2+</sup>, Ni<sup>2+</sup> and SF&F 96365. Thapsigargin, CMC and PCB95 share the same Ca<sup>2+</sup> releasable pools in …
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Multiple sclerosis associated SNPs influencing B cell expression of co-stimulatory receptors and T cell responses
… CD86 and CD40 in freshly collected (ex-vivo) B cells. In my research, I sought to extend this work by investigating the impact of these variants in the context of activation in an effort to refine understanding of the molecular mechanisms underlying the effects of these genotypes on the risk of …
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Characterization of Metabolic Differences in Benign, Slow Developing and Tumor Initiating Ovarian Cancers
… an altered metabolic state within cancer cells known as the Warburg effect. In the Warburg effect, cancer cells participate in an increased rate of aerobic glycolysis with an excess secretion of lactate, allowing for carbon flux into biosynthetic pathways. Exactly which metabolic pathways …
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Tvorba proteinových granulí v diferencovaných buňkách kvasinkových kolonií
… localized cell subpopulations - U and L cells, located in the upper and lower part of the colony, respectively. The U and L subpopulations of cells vary in morphology, metabolic processes and stress resistance. Protein granules are membrane-less "organelles" found in both unicellular and …
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Exploring the function and sensing mechanisms of human enteroendocrine cells using intestinal organoids
… presence of hormone-releasing enteroendocrine cells (EECs), which represent only around 1% of the total gut epithelium. Gut hormones are released in response to cues of different natures to regulate several physiological events, such as nutrient digestion and absorption, intestinal motility, …
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