Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Kynurenic acid"”.
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The role of the ventrolateral medulla in the pressor reflex to static muscular contraction
… VLM microinjections of an excitatory amino acid antagonist, kynurenic acid. The extracellular single unit discharge patterns in 107 of 167 VLM neurons increased by more than 70% during muscular contraction. Computer signal averaging techniques were used to determine if VLM unit discharge …
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Characterisation of transgenic mouse models of Alzheimer's disease
… in this thesis shows that treatment with 1mM kynurenic acid during the slicing process markedly improved baseline synaptic transmission to the level observed in control mice. This shows that kynurenic acid can improve the viability of the slices, and as the compound is a glutamate receptor …
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THE PHYSIOLOGICAL AND PSYCHOLOGICAL EFFECTS OF INDOOR VERSUS OUTDOOR AEROBIC EXERCISE IN FEMALE CANCER SURVIVORS: A LITERATURE REVIEW
… and tumor proliferation through an increase in kynurenic acid and lower risk of breast cancer by an increased energy expenditure to reduce fat tissue, thus decreasing the production of estrogen in post-menopausal women. Adequate levels of vitamin D are important to combat depression and tumor …
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Glutamate regulates neurite outgrowth of descending neurons in culture from larval lamprey
… and often retraction, which was abolished by kynurenic acid. Glutamate-induced neurite retraction appeared to be due, in part, to calcium influx via voltage-gated calcium channels, since application of high potassium media inhibited neurite outgrowth, an effect that was blocked by Co²+ or …
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Cognitive, biological and psychosocial factors predicting interferon-alpha-induced depression
… during the day, and lower baseline levels of kynurenic acid. Patients who developed IFN-α-induced depression also had altered gene expression in a number of pathways relevant for depression such as inflammation and neuroplasticity. Finally, detection and management of depression in this …
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Nucleus accumbens dopamine and investigatory behavior : modulation by the ventral subiculum of the hippocampus through the dopamine cell bodies of the ventral tegmental area
… of the VS by injections of the excitatory amino acid analog N-methyl-D-aspartate (NMDA). Such injections increased investigatory behavior and elevated dopamine in both the DA terminal region of the NAS and the DA cell body region of the VTA. The elevations in VTA DA reflect dendritically released …
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Hypothalamic and medullary modulation of cardiorespiratory responses to hypoxia and hypercapnia
… medulla (VLM) of the excitatory amino acid receptor antagonist kynurenic acid resulted in increased respiratory activity and enhanced respiratory responses to hypoxic and hypercapnic stimuli. Microinjections just caudal, however, typically resulted in apnea. The results suggest that …
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Regulation of Visceral Nociception by GPR35
… and cromolyn) and endogenous agonists (e.g., kynurenic acid) have been identified, which have facilitated research into its function (O’Dowdl et al., 1998; Divorty et al., 2015). In recent years, many of these agonists have been shown to be anti-nociceptive in experimental studies of pain …
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Biochemical aspects of Tourette's Syndrome
… we failed to detect a change in plasma KYN, TRP, kynurenic acid (KYNA), neopterin or cortisol between the fasting TS and control groups. Moreover, none of the variables was affected by dietary status, and thus candidates selected for the larger cross-sectional study were permitted to eat and drink …
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Capillary electrophoresis instrumentation and applications for the analysis of neural systems
… in the neuroactive compounds kynurenine and kynurenic acid which are natively fluorescent. An automated version of a CE-LINF instrument was optimized and evaluated for the quantitation of both tryptophan and tyrosine metabolites. This system uses a metal-vapor, He-Ag laser with 224 nm output …
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Bio-behavioural evaluation of efavirenz and Δ9-tetrahydrocannabinol alone and in combination in rats with respect to psychosis and anxiety
… is similar to that of the hallucinogen, lysergic acid diethylamide (LSD), with EFV having weak partial agonist activity at the serotonin 5-HT2A receptor subtype, while another study reported that EFV induces depression and anxiogenic behaviour. More recently, the addictive properties of EFV has …
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Kynurenines in neurological disorders
… (NMDA) receptor agonist, quinolinic acid (QUIN), and the direct generators of reactive oxygen species, 3-hydroxykynurenine (3HKYN) and 3-hydroxyanthranilic acid (3HANA), as well as the neuroprotective NMDA receptor antagonist, kynurenic acid (KYNA). High performance liquid …
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Studies on preconditioning with adenosine, glutamate and ouabain in rat hippocampal slices
… potassium channel openers such as pinacidil and diazoxide are also known to exert preconditioning against various types of insults. There have been several models of ischaemia used to study preconditioning in vivo and in vitro leading to some confusion over the effects of …
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Investigation Of Whether Sedentary And Physically Active Conditions Lead To Altered Gabaergic Signaling In The Rvlm
… by the neurotransmitter γ-butyric amino acid (GABA). Interestingly, we have shown that following unilateral rvlm blockade, acute inhibition of the intact rvlm lead to decreases in splanchnic sympathetic nerve activity this response was pronounced under sedentary conditions when compared …
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The endocannabinoid system in critical neurodevelopmental periods: Focus on its role in the pathophysiology of schizophrenia as neurodevelopmental disorder [Il sistema endocannabinoide nei periodi critici del neurosviluppo: Focus sul suo ruolo nella fisiopatologia della schizofrenia come disturbo dello neurosviluppo]
… 1) i livelli di cannabinoidi endogeni e dell’acido chinurenico (KYNA) mediante cromatografia liquida e spettrometria di massa, mRNA di elementi del sistema EC e dopaminergico (DA), mediante reazione quantitativa a catena della polimerasi in tempo reale, 3) espressione proteica di elementi del …