Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Kv2.1"”.
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Structure and function of potassium and calcium channels
In this thesis, potassium channels human Kv2.1 and rat Kv2.1, along with calcium channels Ca, 1.2, Ca, 3.1, and chimeras have been studied. These channels were expressed in Xenopuso ocytesf or electrophysiological experiments using two electrode voltage clamp. For protein expression studies,DNA was …
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Investigating Cerebellar Mechanisms of Schizophrenia by Using a Pharmacological Mouse Model: Regulation of Voltage-Gated Potassium Channels
… subunits of voltage-gated potassium channels Kv2.1, Kv6.4, and Kv3.1b in the cerebellar cortex of a phencyclidine-induced mouse model of schizophrenia and explores their potential role in schizophrenia symptoms. In Chapter 3 we show using immunohistochemistry that Kv2.1 is expressed in the …
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Lipid Rafts in Pancreatic Beta- and Alpha-cell Stimulus-secretion Coupling
… and the properties of those ion channels (Kv2.1, Kv4.1/4.3, and Cav1.2 channels) and SNARE proteins were closely regulated by cholesterol-rich lipid rafts. Acute depletion of cholesterol from the plasma membrane with methyl-beta-cyclodextrin caused an elevated basal hormone secretion from …
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Hypoxia-induced responses of porcine pulmonary veins.
… venoconstriction however KV channels containing KV2.1 α subunits may modulate the response. Results with L-NAME suggested endothelial dysfunction may not fully account for the change in PV function after exposure to culture. Therefore the impact of PV maintenance in culture was further explored …
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Molecular Basis of Mechanosensitivity
… additional support that Paddle Chimaera and Kv2.1 are indeed mechanosensitive in cellular contexts. Given the close structural similarity between voltage gated potassium channels and other ion channel families, I extended these studies to include sodium and calcium selective voltage gated ion …
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Synthesis of Insecticidal Mono- and Diacylhydrazines for Disruption of K+ Voltage-Gated Channels, and Elucidation of Regiochemistry and Conformational Isomerism by NMR Spectroscopy and Computation
… linked to inhibition of mosquito K+ channel Kv2.1. The acylation of monoarylhydrazines appears simple, but its regioselectivity is poorly understood when assumed as a function of basicity correlating to nucleophilic strength. We determined the ratio of the rate constants for distal to …
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Caracterización de los canales de potasio dependientes de voltaje (Kv) de los adipocitos blancos de rata
… puede indicar una alta participación del canal KV2.1 en las corrientes. El uso de MgTX (1 y 10 nM) y Psora-4, indica la participación del canal KV1.3 en ambas concentraciones de insulina, de KV1.5 en baja insulina y de heterotetrámeros de la familia Kv1 en alta insulina. La inhibición por IbTX …
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Mass spectrometry methods for imaging cellular lipids, organelles, and proteins
Lipids and their secondary metabolites function as energy storage molecules, structural components in cellular membranes, and messengers that can alter cellular function. Imaging the distributions of various lipid species within tissues and cells can yield insight into the mechanism by which lipids …