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Showing 1 to 3 of 3 for “"KsgA"”.
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The KsgA methyltransferase: Characterization of a universally conserved protein involved in robosome biogenesis
The KsgA enzymes comprise an ancient family of methyltransferases that are intimately involved in ribosome biogenesis. Ribosome biogenesis is a complicated process, involving numerous cleavage, base modification and assembly steps. All ribosomes share the same general architecture, with small and …
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Synthesis, Screening and Cocrystallization of Adenosine Based Inhibitors with Methyltransferases, ErmC' and KsgA
… to mitigate this danger, we targeted ErmC’ and KsgA. Both methylate N6-adenosine of ribosomal RNA, though each serve different roles in their bacterial host. ErmC’ dimethylates A2058 on 23S rRNA, conferring resistance to MLSB antibiotics (macrolides, lincosamides, streptogramin B). KsgA aids in …
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Characterization of Yeast 18S rRNA Dimethyl Transferase, Dim1p
… which is ubiquitously carried out by the Dim1/KsgA methyltransferase family. Although dimethylation and KsgA are dispensable for survival in bacteria, the eukaryotic enzyme Dim1 is essential because of its requirement in the early pre-rRNA processing events. Similarly, few other members of the …