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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Krebs Cycle"”.
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CARDIAC ENERGY METABOLISM IN ISCHAEMIA AND TYPE 1 DIABETES
… labelled metabolic substrates through the Krebs cycle using mass spectrometry was developed and presented. Experimentally-observed isotopologue distributions of Krebs cycle intermediates and proxies were interpreted using this model to determine the percentage of acetyl-CoA oxidised in the …
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A control model of muscle contraction
… are also developed. The systems involved are the Krebs cycle, thick and thin filament regulation, and the generation of a cross-bridge power stroke.
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Designing Mnemonics Serious Games to Promote Knowledge Retention in Memory-Intensive Courses
… on Biology Organization, Cranial Nerves, and Krebs Cycle and taking repeated tests immediately after a 45-minute preparation, one-week gap pre- and post-15-minute revision. In all three tests, students who used the RADAR game performed better in recall than those who did not. Coupled with the …
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RNA-binding proteins in yeast mitochondria
… the further characterisation of Idhp and of the Krebs cycle enzymes citrate synthase 1 (Cit1p) and malate dehydrogenase 1 (Mdh1p) both of which have been identified as RNA-binding proteins without known RNA recognition motifs. Besides analysing their effects on mitochondrial translation and their …
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A Cancer-Specific Study On The Differentially Expressed Protein-Protein Interactions of Fumarate Hydratase
… hydratase (FH) is an enzyme used in the Krebs Cycle to convert fumarate to malate, and it is controlled by the FH gene. In this paper, we will investigate its role in Uterine Corpus Endometrial Carcinoma (UCEC) and how FH-deficient cells affect tumorigenesis. It is well-established that …
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Understanding and modulating macrophage metabolism for improving inflammatory functions against Trypanosoma cruzi infection
… research indicated that glycolysis and broken Krebs cycle support pro-inflammatory functions of macrophages. This study advances our understanding of how T. cruzi infection shifts the metabolism of macrophages and suppress accumulation of oxidative mediators. The first is to evaluate the …
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Regulation and roles of nutrient-dependent mitochondrial fusion
… in levels of metabolites involved in the urea cycle, Krebs cycle and REDOX balance. Findings in this project suggest putative mechanisms linking amino acid metabolism, mitochondrial dynamics and mitochondrial function.
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Distribution of S-(2-Succinyl)Cysteine In the Tissues of Animal Models of Diabetes and Obesity
… electron transport chain (ETC) and a buildup of Krebs cycle intermediates, including fumarate. Previously, we have seen increased succination in adipose tissue of the db/db type 2 diabetic mouse model. Consequently, this study focuses on the distribution of 2SC within various organs, skeletal …
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SALT EXPOSURE AND NITROGEN METABOLISM IN TOMATO (SOLANUM LYCOPERSICUM L.): IMPROVEMENT OF THE RESILIENCE TO ABIOTIC STRESS
… and carbon compounds, affecting biomass and Krebs cycle intermediates. These findings underscore the distinct impacts of specific ions on N and C metabolism under salt stress, advocating for tailored agronomic strategies. The third study focused on the potential of a combined NO3−/NH4+ regime …
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Thermodynamics of Ligand Binding to Glutamate Dehydrogenase
… causing increased ATP production via the Krebs Cycle and excess insulin release. In addition, GDH over activity leads to depletion of glutamate, which is the source of the urea cycle precursor N-acetylglutamate. Reduction of N-acetylglutamate leads to reduced urea cycle activity and …
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Hepatic acetogenesis and ketogenesis in neonatal swine
… (non-ketogenic routes of carbon flux into Krebs cycle intermediates, e.g.) of fatty acid $\beta$-oxidation was also assessed. Low ketogenic capacity in piglets was confirmed by the small change in plasma ($\beta$-OHB) relative to (C8:0) (regression slope) following a dose of C8:0. This …
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Generation of a Medaka Fish Model of Propionic Acidemia for Development of Novel Therapies.
… Because PCC deficiency induces depletion of Krebs cycle intermediates, I investigated the efficacy of an anaplerotic therapy in <i>pccb<sup>del/del</sup></i> medaka fishes. The anaplerotic therapy comprising sodium citrate, ornithine α-ketoglutarate, and glutamine resulted in significant …
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THERMODYNAMIC PROPERTIES OF THE UNFOLDED ENSEMBLE OF PROTEINS
… downhill folding 40-residue protein involved the Krebs cycle of <italic>E. coli</italic>, in its acid-denatured state, and on a sequence-randomized version of this protein. The effect of variability in thermodynamic conditions, such as temperature and the presence of added chaotropes or …
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Transient Metabolic Alterations Induced by Chemotherapeutics in Cancer Persisters
… we demonstrated a transient upregulation in Krebs cycle metabolism in persister cells. We verified that targeting mitochondrial activity can significantly reduce melanoma persister levels. The reported metabolic remodeling feature seems to be a conserved characteristic of melanoma …
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The stimulation or inhibition of growth and acid precipitable material production of Vibrio Fetus by Kreb's cycle intermediates, fatty acids, amines, and miscellaneous compounds
… fetus was determined. The test compounds were Krebs cycle intermediates, lactate, pyruvate, fatty acid, amines, surface active agents, aminobutyrate, hydroxybutyrate, glutathione, asparagine, phenylacetyl chloride, and sodium bicarbonate. Experimental media consisted of the chemically defined …
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Investigation of the mechanism of action of pep carboxylase
… intermediates in the glycolytic pathway and the Krebs cycle. Although citrate and pyrophosphate inhibited the reaction, these inhibitions were readily reversed by additional Mg⁺⁺ in the reaction mixture. A low concentration of hydroxylamine caused no inhibition of the reaction, but rather had a …
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Investigation of chicken embryo metabolism and substrate utilization during later development
… and metabolic adaptations in gluconeogenesis, Krebs cycle activity and glycerol metabolism during the latter half of chicken embryo development.
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Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death
… death. Furthermore, intracellular ATP as well as Krebs cycle intermediates was significantly decreased in HG/PA-treated cells, and the reduced ATP level was restored by anaplerotic input or cataplerotic block. The protective effect by anaplerotic input and cataplerotic block on HG/PA-induced …
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DIETARY INTERVENTIONS TARGETING GLUCOSE METABOLISM AND HYPERINSULINEMIA: A NEW TRANSLATIONAL PERSPECTIVE FOR THE MANAGEMENT OF ACUTE INTERMITTENT PORPHYRIA
… substrates for heme biosynthesis by stimulating Krebs cycle and ameliorate the two major energy-yielding pathways, glycolysis and mitochondrial respiration. Furthermore, it rescued hyperinsulinemia in fasted AIP mice, leading to a great improvement of hepatic glucose metabolism and systemic …
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