Global ETD Search
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Showing 1 to 8 of 8 for “"Knowlesi"”.
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Using biophysical tools to explore the erythrocyte preferences of the zoonotic malaria parasite Plasmodium knowlesi
… for the majority of cases and fatalities, *P. knowlesi* is the only zoonotic malaria parasite, infecting both humans and macaques. It is also the closest relative of human-infecting *P. vivax*, which is currently not possible to continuously culture in vitro. Therefore, as well as being an …
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An in vitro chemogenomic screening system to identify the molecular targets of antimalarial drug candidates
… lines in parallel. I transfected PbACs into *P. knowlesi* parasites grown in vitro in human erythrocytes, establishing that PbACs are maintained stably over many generations and the encoded *P. berghei* genes are transcribed in recipient parasites, resulting in systematic target overexpression. …
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The impact of common and rare human genetic variants on erythrocyte invasion by Plasmodium falciparum malaria parasites
… which is used by both P. vivax and P. knowlesi parasites to invade red blood cells (RBCs). A single nucleotide substitution in the promoter of the gene where erythroid-specific transcription factors bind disrupts the expression of the DARC receptor on the surface of RBCs, and …
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Investigation of the role of HSP70 in the uptake of Granzyme B by Malaria parasite-infected erythrocytes
… P. vivax, P. ovale, P. malariae and P. knowlesi. P. falciparum causes the most severe form of the disease. P. falciparum has a complex life cycle in the human and mosquito hosts exposing the parasite to environmental changes, resulting in upregulation of heat shock proteins (Hsps). These …
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Discovery of Alternative Artemisinin Binding Sites in Plasmodium falciparum ATPase-6
… by the falciparum, malariae, ovale, vivax, and knowlesi species. Artemisinin is an endoperoxide lactone extracted from qinghaosu (Artemisia annua L. or sweet wormwood). It and its derivatives possess uncharacteristically rapid action against Plasmodium falciparum. Artemisinin is unique in its …
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Synthesis, Chemistry, Biological Evaluation And Structure-Activity Relationships Of Rac- And Chiral 6-Desmethyl-5Β –Hydroxy-D-Secoartemisinin And Analogs
… ovale, Plasmodium malariae and Plasmodium knowlesi. The natural product artemisinin is a sesquiterpene lactone with an endoperoxide bridge isolated from the Chinese annual herb qinghao (Artemisia annua L or sweet wormwood). The relatively stable endoperoxide bridge is essential for their …
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Understanding Developmental Decision Making in Malaria Parasites using Single-Cell Transcriptomics
… scRNA-Seq in P. berghei, P. falciparum, and P. knowlesi. This work was followed by specifically profiling the sexual development of wild-type and single knock-out mutant P. berghei parasites using both droplet- and plate-based scRNA-seq. This has led to the identification of novel essential …
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Investigation of azithromycin analogues and proteasome-like inhibitors as quick-killing antimalarials
… falciparum and the zoonotic malaria parasite P. knowlesi. All compounds exhibited low-nanomolar activities against both Plasmodium spp. and showed excellent selectivity for parasites over human cells, suggesting these inhibitors provide viable chemical scaffolds for optimisation. There was no …